ID A0A0G0XBP5_9BACT Unreviewed; 563 AA.
AC A0A0G0XBP5;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Sodium/hydrogen exchanger {ECO:0000313|EMBL:KKS22330.1};
GN ORFNames=UU78_C0018G0002 {ECO:0000313|EMBL:KKS22330.1};
OS Candidatus Roizmanbacteria bacterium GW2011_GWC2_41_7.
OC Bacteria; Candidatus Roizmanbacteria.
OX NCBI_TaxID=1618487 {ECO:0000313|EMBL:KKS22330.1, ECO:0000313|Proteomes:UP000034371};
RN [1] {ECO:0000313|EMBL:KKS22330.1, ECO:0000313|Proteomes:UP000034371}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKS22330.1}.
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DR EMBL; LCBY01000018; KKS22330.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0XBP5; -.
DR PATRIC; fig|1618487.3.peg.293; -.
DR Proteomes; UP000034371; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR42751:SF3; NA(+)_H(+) ANTIPORTER; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 55..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 177..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 406..528
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
SQ SEQUENCE 563 AA; 62575 MW; D89C6792EC3BF00D CRC64;
MNIFTEITII VAIAAFISLI MRLLRQPLVV GYILTGIIVG PYTLNILQST DQVELFSKIG
ITVLLFIVGL NLNPQVIKEL GKVSLVTGVG QVLVTSAIGF SIALLLGIER IAAIYLSIAL
TLSSTIIILK LLSDRGDLNK LYGRIAIGFL IIQDLIASLI LLFISTFSTA GDANLTILIL
FLVVKLLIVL CSLYLVSAYV IPSLFKFVAK SQELLFLFSL AWGLGLAVTL YQIGFSLEIG
ALIAGVTLSV TPYAYEIGSR LRPLRDFFIV LFFILLGSQM VLDKVIELII PTLLFSVFVL
IGNPVILILL LNLLGFKRRT SFMAGLTVAQ ISEFSLILAS LGFSLGHISR DILSLITMVG
LITITGSTYF ILYSERIYPH VEGLLKRLQL LPEKKKEPGS NGQEFDCILF GYDRVGADFI
KIFSKMNVSY IVVDYNPTSV QRLAEQNIPY RFGDAEDVEF LEELNLSKTK LVLSTIPDHK
TNVLLTRKIT RSNKRAISII IAQTIQQAQT LYQEGATYVL MPHYLGARYA SHMISRFGLH
KQAYLEEKEK HIDHINNRLE ISK
//
