ID A0A0G0XKB1_9BACT Unreviewed; 582 AA.
AC A0A0G0XKB1;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=UU85_C0004G0098 {ECO:0000313|EMBL:KKS25339.1};
OS Candidatus Wolfebacteria bacterium GW2011_GWA2_42_10.
OC Bacteria; Candidatus Wolfebacteria.
OX NCBI_TaxID=1619004 {ECO:0000313|EMBL:KKS25339.1, ECO:0000313|Proteomes:UP000034256};
RN [1] {ECO:0000313|EMBL:KKS25339.1, ECO:0000313|Proteomes:UP000034256}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKS25339.1}.
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DR EMBL; LCCF01000004; KKS25339.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0XKB1; -.
DR PATRIC; fig|1619004.3.peg.338; -.
DR Proteomes; UP000034256; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 6..274
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 275..499
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT COILED 427..454
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 27..34
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 582 AA; 67009 MW; 1B348052FB6E7425 CRC64;
MNPLYKNLNE KQVEAVDYQN GPLLIVAGAG SGKTKTLTSR LAAILKLGVS PENIIAITFT
NKAAEEMQNR IMDKKPPFIG TFHSLGARIL KKEANFVDRS RNFSIFDSDD SLRLIKNIIK
NFNLTGEERR DINHFKLRKE FSRIKGGLAE IEDEDEIIGR FFGEYENALE KNNAFDFDDL
IEKPVKIFRQ HPAILEKYQN QFQHILVDEF QDTNVSQYAF IKLLSQKHKN LSVVGDDQQS
IYRFRGSDFR IFLDFEKDWP KTKVVLLEQN YRSSGNIIRA ASALISGNKF QKPKNLWTEN
PDGELLKVIE HRDEDAEAEW IAEKISGSKK SNQSIAVLYR TNAQSRALET VLIERGIPYR
IFGGVRFYER KEIKDIVAAL RWGINPKDAV SLERLKTNLL KKPFLEIKNG IPEKIKKLSP
AELIAYVLEA TDYLNQLKKN YANYQERTEN INELIYFAGN FGNLQEFLEA ISLLQGTDIA
KNNETTANVH LMTIHLAKGL EFDKVFIAGC NEGLLPHQMS YSGEAEIEEE RRLMYVAMTR
AKKELYLNFY NLASRFLYEI PPELVELSAE KSLDDEERYI EM
//
