ID A0A0G2AC26_9BACT Unreviewed; 925 AA.
AC A0A0G2AC26;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN ORFNames=UY72_C0027G0005 {ECO:0000313|EMBL:KKW29989.1};
OS Candidatus Uhrbacteria bacterium GW2011_GWD2_52_7.
OC Bacteria; Candidatus Uhrbacteria.
OX NCBI_TaxID=1618989 {ECO:0000313|EMBL:KKW29989.1, ECO:0000313|Proteomes:UP000034846};
RN [1] {ECO:0000313|EMBL:KKW29989.1, ECO:0000313|Proteomes:UP000034846}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|RuleBase:RU004279};
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKW29989.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LCRD01000027; KKW29989.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G2AC26; -.
DR PATRIC; fig|1618989.3.peg.428; -.
DR Proteomes; UP000034846; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd01609; RNAP_beta'_N; 1.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.40.90; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 2.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR012754; DNA-dir_RpoC_beta_prime_bact.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR NCBIfam; TIGR02386; rpoC_TIGR; 1.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF54; DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279}.
FT DOMAIN 303..585
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
FT REGION 896..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 154..225
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 925 AA; 104919 MW; AA62FCEBFC337111 CRC64;
MAMKFDTLKS TDFDSIRLKV ASPDVIRGWS YGEVTKPETI NYRTQKPEKQ GLFAEEIFGP
SKDWECYCGK YKKIRYKGIV CDKCSVEVTQ ASVRRERMGH IELASPVTHI WFLRGVPSKV
GTVLDMGVQQ LEKVVYFASF IITDVNEIAR EQTIEQVKEE YKAKKKMIEG EVKRDIGRLE
EKFADDKKKL KEESARVEEI AAAKLEELES DFLQVDKDLK ELQVLKVISE TTYHDWSMRY
GHIFDAAIGA EAVLKLLERV NIPETIVKLA EEIATTSSKA KYDRIMRRLK LFRSLEKNGI
LPGWMILRTL PVIPPDLRPM VPLDGGRFAT SDLNDLYRRV INRNNRLRRL YALNAPEVIT
RNEKRMLQEA VDALIDNSAR QSKTVIAATG KKRQLKSLAD ILKGKQGRFR QNLLGKRIDY
SGRSVIVVGP HLKLHQCGIP KKMALELFRP FVISKLIARE YVHNIRSANR FIESERPEVW
DILEEVVSDS YVLLNRAPTL HRLGIQAFRP TLIEGKAIQI HPLVCDAYNA DFDGDQMAVH
VPLTTEAKRE AEELMLSIRN LLKPSFGGPV ATPGKDIAWA CFYLTSVEGK ADEKTIKSFT
DENEALYALH MKKLTFHDWI RVRIKGETLI TTPGRIIVNQ QFPAGIPFQN EILGKKQLAN
IIRDTLEFHG QEFTAQILDN LKDLGFKYAT LSGYSWAMAG LPTLKEKKEL IAEGDRRVRE
VEDYFSQGLL TQSERHTQIV KIWTEIKDRI ADISKNALPH DSSAYTMIES GARGAWGQLT
QMIGMIGLKS SPSGDIIELP VKSSFKEGVS VLEFFISSHG TRKGLTDTAL RTANAGYLTR
RLVDVAQDVV VRDEDCGDDK GVLLTKEESD EIGEPLLVRI LGRVALSDIK VDGERKRPHY
RRSYPRHQGH GQRAHGGSRT LGYDV
//
