ID A0A0G2EIQ3_9PEZI Unreviewed; 3834 AA.
AC A0A0G2EIQ3;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Putative histone acetylase complex subunit {ECO:0000313|EMBL:KKY22727.1};
GN ORFNames=UCDDS831_g03442 {ECO:0000313|EMBL:KKY22727.1};
OS Diplodia seriata.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetes incertae sedis; Botryosphaeriales; Botryosphaeriaceae;
OC Diplodia.
OX NCBI_TaxID=420778 {ECO:0000313|EMBL:KKY22727.1, ECO:0000313|Proteomes:UP000034182};
RN [1] {ECO:0000313|EMBL:KKY22727.1, ECO:0000313|Proteomes:UP000034182}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DS831 {ECO:0000313|EMBL:KKY22727.1};
RA Morales-Cruz A., Amrine K.C., Cantu D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KKY22727.1, ECO:0000313|Proteomes:UP000034182}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DS831 {ECO:0000313|EMBL:KKY22727.1};
RA Lawrence D.P., Travadon R., Rolshausen P.E., Baumgartner K.;
RT "Distinctive expansion of gene families associated with plant cell wall
RT degradation and secondary metabolism in the genomes of grapevine trunk
RT pathogens.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Serine/threonine protein kinase which activates checkpoint
CC signaling upon genotoxic stresses such as ionizing radiation (IR),
CC ultraviolet light (UV), or DNA replication stalling, thereby acting as
CC a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-
CC Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of
CC DNA damage, involved in the regulation of DNA damage response
CC mechanism. Required for the control of telomere length and genome
CC stability. {ECO:0000256|ARBA:ARBA00025079}.
CC -!- SUBUNIT: Associates with DNA double-strand breaks.
CC {ECO:0000256|ARBA:ARBA00011370}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKY22727.1}.
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DR EMBL; LAQI01000073; KKY22727.1; -; Genomic_DNA.
DR Proteomes; UP000034182; Unassembled WGS sequence.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0004672; F:protein kinase activity; IEA:UniProt.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:UniProt.
DR GO; GO:0019219; P:regulation of nucleobase-containing compound metabolic process; IEA:UniProt.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853}.
FT DOMAIN 2638..3193
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3464..3803
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3802..3834
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 156..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1010..1032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3214..3292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3216..3285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3834 AA; 435910 MW; 293BF4CED1EA538F CRC64;
MADRNMEVYL SKLADTTSDL KVKTGVATEI RDSIELYCSG STYGVFLEKF IPVFLKLLEG
APVFVSTSPE QRLRNCILEI LHRLPMSPTE ALEPYAAQIV DRLMVLAKIE NEDNAALCMK
TIMDFERHQT KALQDRVQPF LDLIAEMFEN MDAAVKDTFD SPSGNPASQA IPSTPSNSQY
SQSPRPGSPG AGGPSGGPDL GGEQQQTRHL LKGMQSFKVL AECPIIVVSL FQAYRNCVHK
NVKRFVPLIK NVLLLQAPPQ ERAHAEAKAR NDIFTGVSKE IKNRAAFGEF ITAQVKTMSF
LAYLLRVYAQ QLTDFLPTLP DIVVRLLQDC PREKSGARKE LLVAIRHIIN FNFRKIFLKK
IDELLDERTL IGDGLTVYET MRPLAYSMLA DLIHHLRESL SQEQIRRTIE VYTKNLHDSF
PGTSFQTMSA KLLLNMAECI AKLEPKQEAR YYLVMILNAI GDKFAAMNRQ FDNAVKVSNQ
FSSPTIEATP ENYLAEKDSP PDWDEIDIFN ATPIKTSNPR ERASDPIADN KFLFKNLLHG
LKNLFYQLRV CNPPKIKEEI DPSVPTPANW HEVSFGYNAE EVEVLIKLFR EGAQVFRYYG
VEKTPGEKES LSPTELLANQ HMMSSGKEEK ELLEAFATVF HHIDPATFHE VFESEIPHLY
EMMFEHNPLL HVPQFLLASE ATSPSFAGML LQFLMGNIDE VGTSDVKKSS ILLRLFKLSF
MAVTLFSQQN EQVLLPHVTK IVTRSIELST TAEEPMNYFL LLRSLFRSIG GGRFEHLYKE
ILPLLEMLLE VLNNLLIAAR KPSERDLFVE LSLTVPARLS NLLPHLSYLM RPLVVALRAG
SDLVGQGLRT LELCVDNLTA DYLDPIMAPV IDELMQGLWE HLKPTPYSHF HAHTTMRILG
KLGGRNRRFI NGPPPLQYKS YADDEPSIDI RLIGSLKDRA FPTSIGVENA IGKLWETPKT
PAAKKSDCFH KQQAFKFITS QVKLLLGADS LPEDFAQLVR LQADDLSNGT HDRGSDVLEA
SERDKSNTKK DAQQDSLRKL LKAVMFCNSI PELKGEATSF MAHICRHFAL LEVGTALATI
KHRKKPFDVN SGEGPVVIES RVILEAISDS LASDHVEVRE AAEEALKTLY QAAVTIFGDP
SKAEKLTLFK HLADIFCHNC HQEEWFVKHG GTLGIDILTT KLGLSDAWIN EGGRLNHFSR
ALVYVMQDMP LDLTSSTRHN SQTTLEKLLR RCSGLWSKDD LKSPPNSDNK LLSLCGFLVT
MLSHSNKHVR KAAQDNLKII AESTHTEVHE LVLPVSKRLL DPIFNKPLRA LPFSIQIGYI
DAVTFCLKLG HGVLTFNELL TRLLTEALAL ADAEDEGLTA KPYEQRNAEA IVNLRVACIR
LLSTAQTFPE FSSNPPNQTF LRVIAVFFKA LYSKSPQVVD AANAGLQGVL HTTNKLPKDV
LQSGLRPILV NLQDPKKLTV EGLDGLARLL KLLTNYFKVE IGSRLLDHMK VIADQRVLQA
TSFGLIEQHK AMKTVTAILN VFHLLPAAAV SFLGQLVQKV MELEGALRRT HYSPFRKPLI
KYLNHYPKEA WNDFAPRIRD HASGRFFAQI MADPASGPLR EVLVNDTQGF INAFAIDDDP
MRWPASINAI HVVDSVCKYP ETSTWLVNHA DLRKALIEAG KSLETRLRQN KIEASLRLAV
DQAGERLIGV FTNYLTHEPD NLDFFVEIID AVTAEELKAS PALFNFIYKI MISNESVDYW
RSLIIRCIDL YTGRNTSQKT KTFVFHNIVN PVFAMDVMRN WDSLFGAAKG TQLMDRSMTE
TIHNRLWRVY SMEQVEETGQ LGVDHSRMEL LQMTTLLVKY HHGLIQDTRK DVIKFGWNYI
RLEDIINKHA AYVLIAYFIA HYETPPKIAI QIYSQLLRAH QNEGRPLVMQ ALEVLAPVLK
KRIGGVDNKQ PPMWARIPKK ILTEESSNLQ QLISIFNFLV RYPDLFYEAR EPLSTIIIPS
LPKIAQPPSL GNDHKKIALN LINLLRRWEM RSANESGLSL DHLSIGSRSP KRRHDGSMVA
PDLSSRQFVA PPALRQALIK YLATFIMLIP ERYPVPSTKI RESTASHNAP PAQSTDACEM
AVELLQDLLS AYWSDLDIDS ILARVENVIM TEPKQEEKPE VATTRLINAL QVLKVFVNVR
SGDWILAHLP QLQKVLEKPI RNESAEIQDC LHALSDEDNR VKLKPLMKRI LEVLPEPSTD
EDGATTEETP STEFVAFCNQ VATETLGNNN NIAAVNLLWT LCQHRPDDVD QQHIVQVVKV
LNTMSREHLT APSQGQGMMH GMRSEGQNGA PMGSYDHEIQ VGLILKAIDF LAARMSQLGD
QRRPFLTFLA SLVERSPSNS ICQKIVDLTD GWIFDSNEPV PTLKEKTAVL SKMQAFESRA
DKTLLTKFLT LVIRIYEDPK ITRSELTVRM EHAFLIGTRA EDVEMRNRFM TIFDRSLSRT
ASARLNYVIA GQNWDILGRS FWLNQVVHLM FGSVEMNNTA QLHSEDFRVM SASTLFGTYS
RDPRVGDVMV DDQLESYVSN HRQFVNSFGD VKIRDLFDPL THLQHVDSNL THDIWVHFFP
LCWSALAKDD QVDLEKGLVA LLTKDYHMQS IDERPNCVQT VLEGVVKARP RVKFPPHVMK
YLAQTYNAWY TALCYLEDYA IDPIIDTAQV RESNLDALLE VYSQLEEHDL FYGTWRRRCQ
YVETNAALSY EQNGMWDNAQ KLYETAQIKA RTGALPFSQG EYMLWEDHWV VCAQKLQQWE
ILSDFAKHEN FSDLYLESMW RIFDAWQNNE QREQLESSIK AVSDAPTPRR IFFQAFLSLL
KLHGGHETNQ DFNKVVDDAI QLSIRKWHQL PKRTTNAHIP LLQNFQQLVE LHDASVICSS
LGGTTQQNLD HKSQELKLLL STWRDRLPNF WDDINAWQDL VTWRQHIFHL INGKYLQLLP
QQQGNASGNS YAYRGYHETA WIINRFAHVA RKHSLPDVCI NQLSRIYTLP NIEIQEAFLK
LREQAKCHYQ NKQELNSGLD VINNTNLNYF GAQQKAEFYT LKGMFLAKLG QTNEANDAFG
SALYFDIKLP KAWKEWGRYN DNLFKQSPQV LDKAAAAISC YLEAASQYKN HKSRELLGRI
LWLLSLDNSE RDLAKTFETF KGDTPSWYWI TYIPQLFVGL SRPEAPICRQ VLGKLAKTYP
QALFFQLRTS REDFHQIRKQ QEAKEAREKL ILEKKKQAQQ GTSGAQSQNQ SSDTKQGSPS
RPNTSSGSEQ KLGASSGSDN NSQSGGQNNT NGQKTENGQS TPSTEQPPQP RKPWDYVEEV
MAALKTAFPL LALSMETMSD GIAKHFKCPP DEDAYRLIVA LLNDGLSYIG RQPALYQETK
LPTSTEANIT RFAESVLPPH IRRSFEADFV TKKPTMYEYI QKLRKWRNRF EERLDRRRLT
HHLESYTTHL SDFKYQKFDE IEVPGQYLLH RDKNQDFVRI ERFLPDIDLV RTVGFCHRRL
KIRGHDGSTH PFAIQHPAAR NCRREERILQ LFRIFNTTLS KRKESRRRNL QFTLPLMVPL
SPGVRMVQDD SSYISLQGIY EDYCRRNGIN KDDPILFAIE KLRSLGPQLL SAQPPQGHPN
ADVVRQRNIE QSTAIRLEVF AAIQEKYVPP TAVLDYFNAI YPSFADLWLF RRQFSYQLAA
LTFITYIMHM NTRYPHKMNI SRRTGNIWGS ELVPSMAGGK PLFHNPEPVP FRLTPNLQTM
MGPLATEGIF APALMAIARC VVEPDGELEM QLSIFVRDEM VHWHTQQHRQ HVQDGQLRES
VEHNSGQIVK RAKSLAEVPN SNNLPANQTV VDLVSVAVNP GKLCMTDPLW MPYL
//