ID A0A0G2JED4_MOUSE Unreviewed; 420 AA.
AC A0A0G2JED4;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=SH2B adaptor protein 2 {ECO:0000313|Ensembl:ENSMUSP00000142728.2};
GN Name=Sh2b2 {ECO:0000313|Ensembl:ENSMUSP00000142728.2,
GN ECO:0000313|MGI:MGI:1345171};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000142728.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000142728.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000142728.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000142728.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000142728.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001289868.1; NM_001302939.1.
DR AlphaFoldDB; A0A0G2JED4; -.
DR SMR; A0A0G2JED4; -.
DR EPD; A0A0G2JED4; -.
DR jPOST; A0A0G2JED4; -.
DR ProteomicsDB; 332659; -.
DR Antibodypedia; 31045; 80 antibodies from 17 providers.
DR DNASU; 23921; -.
DR Ensembl; ENSMUST00000196447.2; ENSMUSP00000142728.2; ENSMUSG00000005057.14.
DR GeneID; 23921; -.
DR AGR; MGI:1345171; -.
DR CTD; 10603; -.
DR MGI; MGI:1345171; Sh2b2.
DR VEuPathDB; HostDB:ENSMUSG00000005057; -.
DR GeneTree; ENSGT00950000183191; -.
DR OrthoDB; 2995825at2759; -.
DR BioGRID-ORCS; 23921; 1 hit in 78 CRISPR screens.
DR ChiTaRS; Sh2b2; mouse.
DR Proteomes; UP000000589; Chromosome 5.
DR Bgee; ENSMUSG00000005057; Expressed in brown adipose tissue and 167 other cell types or tissues.
DR ExpressionAtlas; A0A0G2JED4; baseline and differential.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01231; PH_SH2B_family; 1.
DR Gene3D; 6.10.140.110; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR015012; Phe_ZIP.
DR InterPro; IPR036290; Phe_ZIP_sf.
DR InterPro; IPR030523; SH2B.
DR PANTHER; PTHR10872; SH2B ADAPTER PROTEIN; 1.
DR PANTHER; PTHR10872:SF4; SH2B ADAPTER PROTEIN 2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF08916; Phe_ZIP; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF109805; Phenylalanine zipper; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:A0A0G2JED4,
KW ECO:0007829|MaxQB:A0A0G2JED4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 186..299
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 143..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 420 AA; 45252 MW; 0BCA4599224B9A73 CRC64;
MNGATPSSAA APAPVPDWRQ FCELHAQVAA VDFAHKFCRF LRDNPTYDTP DAGTSFSRHF
AANFLAVFSE EVRRVLGSAA DTMEPEPAVT SVTSALKTAT YGHSRSSEDV SAHAATKARV
RKGFSLRNMS LCVVDGVRDL WHRRSSPEPD GGATPKAAEP ASEPRDKWTR RLRLARTLAA
KVELVDIQRE GALRFMVADD AASGPGGTAQ WQKCRLLLRR AVAGERFRLE FFVPPKASRP
KVSIPLSAII EVRTTMPLEM PEKDNTFVLK VENGAEYILE TIDSLQKHSW VADIQGCVDP
GDSEEDTGLS CARGGCLASR VASCSCELLT DADMPRPPET TTAVGAVVTA PHGRARDTVG
ESLAHVPLET FLQTLESSGG VSENNNPGTT GVPTPFYRDP CGASEVVTFQ PVVSTVVLAF
//
