ID A0A0G2JVW3_RAT Unreviewed; 2524 AA.
AC A0A0G2JVW3;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Ankyrin repeat domain 17 {ECO:0000313|Ensembl:ENSRNOP00000069642.1};
GN Name=Ankrd17 {ECO:0000313|Ensembl:ENSRNOP00000069642.1,
GN ECO:0000313|RGD:1562348};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000069642.1, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000069642.1, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000069642.1,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0007829|PubMed:22673903}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [3] {ECO:0000313|Ensembl:ENSRNOP00000069642.1}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000069642.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_006250828.1; XM_006250766.3.
DR AlphaFoldDB; A0A0G2JVW3; -.
DR SMR; A0A0G2JVW3; -.
DR STRING; 10116.ENSRNOP00000069642; -.
DR jPOST; A0A0G2JVW3; -.
DR Ensembl; ENSRNOT00000086542.2; ENSRNOP00000069642.1; ENSRNOG00000002940.8.
DR GeneID; 289521; -.
DR AGR; RGD:1562348; -.
DR CTD; 26057; -.
DR RGD; 1562348; Ankrd17.
DR GeneTree; ENSGT00940000153768; -.
DR InParanoid; A0A0G2JVW3; -.
DR OrthoDB; 5480610at2759; -.
DR Proteomes; UP000002494; Chromosome 14.
DR Bgee; ENSRNOG00000002940; Expressed in lung and 19 other cell types or tissues.
DR ExpressionAtlas; A0A0G2JVW3; baseline and differential.
DR GO; GO:0000785; C:chromatin; ISO:RGD.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0001673; C:male germ cell nucleus; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0003682; F:chromatin binding; ISO:RGD.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0001955; P:blood vessel maturation; ISO:RGD.
DR GO; GO:0042742; P:defense response to bacterium; ISO:RGD.
DR GO; GO:0045087; P:innate immune response; ISO:RGD.
DR GO; GO:0051151; P:negative regulation of smooth muscle cell differentiation; ISO:RGD.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; ISO:RGD.
DR GO; GO:0045787; P:positive regulation of cell cycle; ISO:RGD.
DR GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; ISO:RGD.
DR GO; GO:1900245; P:positive regulation of MDA-5 signaling pathway; ISO:RGD.
DR GO; GO:1900246; P:positive regulation of RIG-I signaling pathway; ISO:RGD.
DR GO; GO:0006275; P:regulation of DNA replication; ISO:RGD.
DR CDD; cd22502; KH-I_ANKRD17; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 8.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR047375; KH-I_ANKRD17.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR PANTHER; PTHR23206:SF1; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 17; 1.
DR PANTHER; PTHR23206; MASK PROTEIN; 1.
DR Pfam; PF00023; Ank; 3.
DR Pfam; PF12796; Ank_2; 7.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00013; KH_1; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 25.
DR SMART; SM00322; KH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 20.
DR PROSITE; PS50088; ANK_REPEAT; 20.
DR PROSITE; PS50084; KH_TYPE_1; 1.
PE 1: Evidence at protein level;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Coiled coil {ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A0G2JVW3};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT REPEAT 187..219
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 220..252
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 253..285
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 287..319
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 320..352
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 353..385
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 386..418
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 450..482
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 483..515
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 516..548
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 550..582
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 994..1026
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1027..1059
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1061..1093
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1094..1126
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1129..1161
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1163..1195
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1196..1228
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1231..1263
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1264..1296
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1636..1706
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT REGION 663..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1391..1629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1719..1738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1818..1907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1923..2061
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2185..2243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2302..2368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 695..816
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 664..682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1405..1441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1444..1479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1508..1565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1583..1618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1720..1738
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1856..1907
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1923..1941
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1963..2025
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2039..2061
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2185..2212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2302..2322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2354..2368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2524 AA; 267313 MW; 995D27BAB2957F5E CRC64;
MVETAAEMEA YVLEDILEVE SFILDQDDLE NPMLETASKL LLSGTADGAD LRTVDPETQA
RLEALLEAAG IGKLSTADGK AFADPEVLRR LTSSVSCALD EAAAALTRMR AESTANAGQS
DNRSLAEACS EGDVNAVRKL LIEGRSVNEH TEEGESLLCL ACSAGYYELA QVLLAMHANV
EDRGIKGDIT PLMAAANGGH VKIVKLLLAH KADVNAQSST GNTALTYACA GGYVDVVKVL
LESGASIEDH NENGHTPLME AGSAGHVEVA RLLLENGAGI NTHSNEFKES ALTLACYKGH
LEMVRFLLEA GADQEHKTDE MHTALMEACM DGHVEVARLL LDSGAQVNMP ADSFESPLTL
AACGGHVELA ALLIERGASL EEVNDEGYTP LMEAAREGHE EMVALLLGQG ANINAQTEET
QETALTLACC GGFLEVADFL IKAGADIELG CSTPLMEAAQ EGHLELVKYL LAAGANVHAT
TATGDTALTY ACENGHTDVA DVLLQAGADL EHESEGGRTP LMKAARAGHV CTVQFLISKG
ANVNRTTANN DHTVLSLACA GGHLAVVELL LAHGADPTHR LKDGSTMLIE AAKGGHTSVV
CYLLDYPNNL LAAPPPDVTQ LTPPSHDLNR APRVPVQALP MVVPPQEPDK PPANVAATLP
VRNKAASKQK SNSHLPANSQ DVQGYITNQS PESIVEEAQG KLTELEQRIK EAIEKNAQLQ
SLELAHADQL TKEKIEELNK TREEQIQKKQ KILEELQKVE RELQLKTQQQ LKKQYLEVKA
QRIQLQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQSCQH LGLLTSVGVG EPLPEGDYAR
LQQVDPVLLK DEPQQTAAQM GFAPIQPLAM PQALPLAAGP LPPGSIANLT ELQGVIVGQP
VLGQAQLAGL GQGILTETQQ GLMVASPAQT LNDTLDDIMA AVSGRASAMS NTPTHSIAAS
VSQPQTPTPS PIISPSAMLP IYPAIDIDAQ TESNHDTALT LACAGGHEEL VQTLLERGAS
IEHRDKKGFT PLILAATAGH VGVVEILLDN GADIEAQSER TKDTPLSLAC SGGRQEVVEL
LLARGANKEH RNVSDYTPLS LAASGGYVNI IKILLNAGAE INSRTGSKLG ISPLMLAAMN
GHTAAVKLLL DMGSDINAQI ETNRNTALTL ACFQGRTEVV SLLLDRKANV EHRAKTGLTP
LMEAASGGYA EVGRVLLDKG ADVNAPPVPS SRDTALTIAA DKGHYKFCEL LIGRGAHIDV
RNKKGNTPLW LAANGGHLDV VQLLVQAGAD VDAADNRKIT PLMAAFRKGH VKVVRYLVKE
VNQFPSDSEC MRYIATITDK EMLKKCHLCM ESIVQAKDRQ AAEANKNASI LLEELDLEKL
REESRRLALA AKREKRKEKR RKKKEEQRRK LEEIEAKNKE NFELQAAQEK EKHKVEEEPE
VLTEPPSATT TTTIGISATW TTLAGSHGKR NNTITTTSSK RKNRKNKITP ENVQIIFDDP
LPISYSQPEK ASGESKSSST SESGDSDNMR ISSCSDESSN SNSSRKSDNH SPAVATATVA
SKKQPSVLVT FPKEERKSVS GKASIKLSET VNEGTSNSLS TCTKSGPSPL SSPNGKLTVA
SPKRGPKREE GWKEVVRRSK KVSVPSTVIS RVIGRGGCNI NAIREFTGAH IDIDKQKDKT
GDRIITIRGG TESTRQATQL INALIKDPDK EIDELIPKNR LKSSSANSKI GSSAPTTTAA
NSSLMGIKMT SVALSSTSQT ATALTVPAVS SASTHKTIKN PVNNVRPGFP VSLPLAYPPP
QFAHALLAAQ TFQQIRPPRL PMTHFGGTFP PAQSTWGPFP VRPLSPARAT NSPKPHMVPR
HSNQNSSGSQ VNSAGSLTSS PTTTTSSSAS AVPGTTSNGS PSSPSVRRQL FVTVVKTSNA
TTTTVTTTAS NNSTAPTNAT YPMPTAKEHY PVSSPSSPSP PAQPGGVSRN SPLDCGSASP
NKGASSSEQE ASSPPVVETT NSRPSHSSTS SGSSSGHSTQ QQPPGSVPQE PRPPLQQSQV
PSPDVRMTVP PTATSSAPVV VPSTAPMTYP MPQTQMGCSQ PPKMETPAIR PPSHGTTAPH
KNSAPVQNSS VAVLNVNHIK RPHSVPSSVQ LPSTLSTQSA CQNSVHPANK PVAPNFSAPL
PFGPFSTLFE NNPTNAHAFW GGPVVSSQST PESMLSGKSS YLPNSDPLHQ SDTSKAPGFR
PPLQRPAPSP SGIVNMDTPY GSVTPSSTHL GNFASSLSGG QMYGPGAPLG GAPIGGAPLG
GAPAAANFNR QHFSPLSLLT PCSSASNESP AQSVSSGVRA PSPAPSSVPL GSEKPSSVSQ
DRKVPVPIGT ERSARIRQTG TSAPSVIGSN LSTSVGHSGI WSFEGIGGNQ DKVDWCNPGM
GNPMIHRPMS DPGVFSQHQA MERDSTGIVT PSGTFHQHVP AGYMDFPKLG SMPFSVYGNA
MLPPVAPIPD GAGGPIFNGP HSADPSWNSL IKMVSSSTEN NGPQTVWTGP WAPHMNSVHM
NQLG
//
