ID A0A0G2JYM7_RAT Unreviewed; 930 AA.
AC A0A0G2JYM7;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=von Willebrand factor C and EGF domains {ECO:0000313|Ensembl:ENSRNOP00000070716.2};
GN Name=Vwce {ECO:0000313|Ensembl:ENSRNOP00000070716.2,
GN ECO:0000313|RGD:1309910};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000070716.2, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000070716.2, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000070716.2,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000070716.2}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000070716.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; NP_001258240.1; NM_001271311.1.
DR AlphaFoldDB; A0A0G2JYM7; -.
DR STRING; 10116.ENSRNOP00000070716; -.
DR PaxDb; 10116-ENSRNOP00000028268; -.
DR Ensembl; ENSRNOT00000079679.2; ENSRNOP00000070716.2; ENSRNOG00000060269.2.
DR GeneID; 309209; -.
DR KEGG; rno:309209; -.
DR AGR; RGD:1309910; -.
DR CTD; 220001; -.
DR RGD; 1309910; Vwce.
DR VEuPathDB; HostDB:ENSRNOG00000060269; -.
DR eggNOG; KOG1216; Eukaryota.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000161089; -.
DR InParanoid; A0A0G2JYM7; -.
DR OMA; PGRCYFH; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000060269; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0098586; P:cellular response to virus; IBA:GO_Central.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 6.20.200.20; -; 4.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR47333; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47333:SF1; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12662; cEGF; 2.
DR Pfam; PF00093; VWC; 3.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00214; VWC; 6.
DR SMART; SM00215; VWC_out; 4.
DR SUPFAM; SSF57603; FnI-like domain; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01208; VWFC_1; 3.
DR PROSITE; PS50184; VWFC_2; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..930
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035318242"
FT DOMAIN 142..180
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 181..219
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 220..262
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 377..434
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 492..553
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 559..619
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 620..678
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REGION 291..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 732..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 811..862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 879..930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..862
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 930 AA; 97752 MW; 0437F4CB293520D7 CRC64;
MWARLLLHIA YILIPLLGSS ARGHTGRKAS GHYSAERRRL GPHVCLSGFG SGCCPGWAPS
MGSGHCTLPL CSFGCGRGIC IAPNVCSCQD GEQGATCPEA HGSCGEYGCD LTCNHGGCQE
VARVCPVGFL MTETAVGIRC ADIDECLSSS CEGHCVNTEG GFVCECGPGM QLSADRHSCQ
DTDECLGTPC QQRCKNSIGS YKCSCRAGFH LHGNRHSCID INECRRPQER RICHHTCHNT
VGSFLCTCRP GFRLQADRVS CEAFPKAVLA PSAILQPRQQ PAKMSLLLPE AGRPALSPGH
SPPPGAPGYP TGVRTISQPS ATQAPPTFFA TQLTSTPLPS SSPLGTLGPP SLLHREVVGT
PSSPRGPESP KLGAGPSSCR HLGATYESGS RWRQPGCSQC LCQDGEVTCG EVRCDSTCSH
PIPPSEGGCC PSCTGCFHSG VIRAEGDVFS PPEENCTVCV CLAGNVSCIS PECPPGPCKA
SPQSDCCTCA PGRCYFHGRW YTDGAVFSGG GDDCTTCVCQ NGEVECSFTP CPELECPREE
WLLGPGQCCF TCREPTPTTG CSLDDNGVEF PIGQIWSPGD PCELCVCQAD GSVSCKRTDC
VDSCPHPIRV PGQCCPDCSA GCTYTGRIFY NNETFPSVLD PCLSCICLLG SVACSPVDCP
ITCTYPFHPD GECCPVCHDC NFEGRKVVNG QVFTLDDEPC TRCVCQLGEV SCETVPCQPV
CTDSSCPDSL FPQEEKQQPS PHGDLAKAAR NPRGDTEVPV NCSSCPGPPS ASPARPTSQL
LKLLLRTNLS NVQSASPGPP VAQASSSLLL DPQGTVLGKP GASRPSEPSG GAPVSPGLPT
LPPAILGTPS STVTPESSSS TFRVRTAFQW PLSTTRLTEA ETPSVTDTDL SETLATSSRP
QRLSATLLDT PNPVPQQSTA DTLKEEESTI
//
