ID A0A0G2JYU1_RAT Unreviewed; 680 AA.
AC A0A0G2JYU1;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Leukocyte immunoglobulin like receptor B1 {ECO:0000313|Ensembl:ENSRNOP00000070789.2};
GN Name=Lilrb1 {ECO:0000313|Ensembl:ENSRNOP00000070789.2,
GN ECO:0000313|RGD:6487069};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000070789.2, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000070789.2, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000070789.2,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000070789.2}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000070789.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_001076276.1; XM_001076276.5.
DR RefSeq; XP_003748759.1; XM_003748711.4.
DR RefSeq; XP_006228109.1; XM_006228047.3.
DR AlphaFoldDB; A0A0G2JYU1; -.
DR Ensembl; ENSRNOT00000080799.2; ENSRNOP00000070789.2; ENSRNOG00000066254.1.
DR GeneID; 100912456; -.
DR KEGG; rno:100912456; -.
DR AGR; RGD:6487069; -.
DR CTD; 10859; -.
DR RGD; 6487069; Lilrb1.
DR VEuPathDB; HostDB:ENSRNOG00000066254; -.
DR GeneTree; ENSGT01100000263478; -.
DR OMA; IPKANAH; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000053260; Expressed in spleen and 20 other cell types or tissues.
DR ExpressionAtlas; A0A0G2JYU1; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProt.
DR CDD; cd16843; IgC2_D1_D2_LILR_KIR_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR11738:SF182; LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY B MEMBER 3-RELATED; 1.
DR PANTHER; PTHR11738; MHC CLASS I NK CELL RECEPTOR; 1.
DR Pfam; PF00047; ig; 2.
DR Pfam; PF13895; Ig_2; 2.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..680
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035280500"
FT TRANSMEM 647..668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 424..506
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 524..595
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 680 AA; 75290 MW; 0E2473BECE64A9AA CRC64;
MTFTFTALLC LGLTLGLWIP VLTGSLPKPI LRVQPDSVVS MGTTVTFICE ETIGAKESDL
YRNGNLQRRV PKNNQKPTNK TEFLFLNVGH QNAGQYHCSY KSQGKSSDYS EPLELVVTGA
YSKPSLSVQS NPVVTSGGYV TLKCEPSHYD HTLILTVEGS QKPSWRQETQ CNHYTGKCHA
LFPVGPLTSN QRWIFRCYSY ETNTPQVWSA PSEPVELLVS GKLQKPTIKA EPGSVMHSGR
AMTIWCQGDL DAEIYFLYKE GSHNTQSTQT LQQPGNKAKF FIPSVTQSHA GQYGCYCYSS
AGWSEPSDTL ELVVTGMYNY YPLMLSGLPS PVVPEGGNVT LHCTSLRNYD KFILTKEDQK
FTNSLDTEYI PSTGQHQALF VLGPMTPNYS GTFRCYGYYK NTPQLWSVPS ELLKILISGP
LRKPSLLSHQ GRILNPGMSL TLQCYSDINY DKFALYKEGG ADIIQSSSQW TKAGLSKANF
TLGYVNHSTG GQYRCYGAHN LSSELSASSD PLDILITGQI YDTPSLSVMP NSTVHSGENV
TLMCWSKYSV DTFILSKEGS GQPPLRRKSK FQDQQYQSEF SMRAVTSKLS GTYRCYGSPD
SSLYLLSFAS APVELIVSES IEASSWPAKR FITTATPENQ DHTMENLIRM GMAVLVLIVL
SILAAVAWQS HRQTHHAAGK
//
