ID A0A0G2K2M9_RAT Unreviewed; 2659 AA.
AC A0A0G2K2M9;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Serine/arginine repetitive matrix 2 {ECO:0000313|Ensembl:ENSRNOP00000072307.2};
GN Name=Srrm2 {ECO:0000313|Ensembl:ENSRNOP00000072307.2,
GN ECO:0000313|RGD:1310163};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000072307.2, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000072307.2, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000072307.2,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0007829|PubMed:16641100}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=16641100; DOI=10.1073/pnas.0600895103;
RA Hoffert J.D., Pisitkun T., Wang G., Shen R.F., Knepper M.A.;
RT "Quantitative phosphoproteomics of vasopressin-sensitive renal cells:
RT regulation of aquaporin-2 phosphorylation at two sites.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
RN [3] {ECO:0007829|PubMed:22673903}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [4] {ECO:0000313|Ensembl:ENSRNOP00000072307.2}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000072307.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CWC21 family.
CC {ECO:0000256|ARBA:ARBA00005954}.
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DR IntAct; A0A0G2K2M9; 5.
DR STRING; 10116.ENSRNOP00000072307; -.
DR jPOST; A0A0G2K2M9; -.
DR PaxDb; 10116-ENSRNOP00000006370; -.
DR Ensembl; ENSRNOT00000091287.2; ENSRNOP00000072307.2; ENSRNOG00000058561.2.
DR AGR; RGD:1310163; -.
DR RGD; 1310163; Srrm2.
DR VEuPathDB; HostDB:ENSRNOG00000058561; -.
DR eggNOG; KOG1869; Eukaryota.
DR GeneTree; ENSGT00940000161127; -.
DR InParanoid; A0A0G2K2M9; -.
DR Reactome; R-RNO-72163; mRNA Splicing - Major Pathway.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000058561; Expressed in cerebellum and 20 other cell types or tissues.
DR GO; GO:0015030; C:Cajal body; ISO:RGD.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; ISO:RGD.
DR GO; GO:0016607; C:nuclear speck; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; ISO:RGD.
DR GO; GO:0071005; C:U2-type precatalytic spliceosome; ISO:RGD.
DR GO; GO:0070742; F:C2H2 zinc finger domain binding; ISO:RGD.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; ISO:RGD.
DR CDD; cd21375; cwf21_SRRM2; 1.
DR InterPro; IPR013170; mRNA_splic_Cwf21_dom.
DR InterPro; IPR024945; Spt5_C_dom.
DR InterPro; IPR047490; SRRM2_cwf21.
DR PANTHER; PTHR36562:SF5; RHODANESE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR36562; SERINE/ARGININE REPETITIVE MATRIX 2; 1.
DR Pfam; PF08312; cwf21; 1.
DR SMART; SM01104; CTD; 1.
PE 1: Evidence at protein level;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A0G2K2M9};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT DOMAIN 502..637
FT /note="Spt5 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01104"
FT REGION 146..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..1057
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1089..1200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1213..2039
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2209..2255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2294..2659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..290
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..360
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..472
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..659
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..835
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..870
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 901..1022
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1035..1055
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1164..1199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1295..1329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1338..1381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1396..1460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1544..1563
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1564..1605
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1673..1687
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1702..1722
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1738..1762
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1769..1963
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1973..2021
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2211..2235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2308..2323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2352..2392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2428..2468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2490..2504
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2505..2552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2567..2586
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2587..2618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2619..2635
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2659 AA; 290136 MW; 87AF87B666418DF7 CRC64;
MYNGIGLPTP RGSGTNGYVQ RNLSLVRGRR GERPDYKGEE ELRRLEAALV KRPNPDILDH
ERKRRVELRC LELEEMMEEQ GYEEQQIQEK VATFRLMLLE KDVNPGGKEE TPGQRPVVTE
THQLAELNEK KNERLRAAFG ISDSYVDGSS FDPQRRAREA KQTAPEPPKP YRYSGENLNL
LPTLWWFSFR SRSTTPAPKS RRAHRSTSAD SASSSDTSRS RSRSAAAKIH TTSLTGQSPP
LASGHQGEVD APSEPGATNI QQPSSPDPST KQSSSPYEDK DKKEKSAVRP SPSPERSSTG
PELPAPTPLL VEQHGDSPRP LAAIPSSQEP VNPSSEASPT RGCSPPKSPE KPPQSSSSES
CPPSPQPTKL SRHASSSPES LKPTPAPGSR REISSSPTSK NRSHGRAKRD KSHSHTPSHR
AGRSRSPATK RGRSRSRTPT KRGHSRSRSP QWRRSRSAQR WGKSRSPQRR GRSRSPQRPG
WSRSRNTQRR GRSRSARRGR SHSRSPATRG RSRSRTPARR GRSRSRTPAR RRSRSRTPAR
RRSRSRTPAR RGRSRSRTPT RRRSRTRSPV RRRSRSRSQA RRSGRSRSRT PARRSGRSRS
RTPARRGRSR SRTPARRSGR SRSRTPARRG RSRSRTPARR RSRSRSLVRR GRSHSRTPQR
RGRSGSSSER KNKSRTSQRR SRSNSSPEMK KSHVSSRRSR SLSSPRSKAK SLRRSLSGSS
PCPKQKSQTP TRRSRSGSSP PKQKSKTPPR QSRSNSPQPK VKSGTPPRSG SVTNMQAEEC
STTPQRQSHS ESSPDGEVKS RTPSRQSCSG SSPRVKSSTP PRQSPSRSSS PQPKVKAVIS
PRRRSHSSSS SPSPSRVTSR TPQRKSRSVS PCPKVDSRLL RHSRSRSSSP DTKMELGTPL
RHSHSGSTSP YPKSMLQTPP DQNLSGSKSP CPQKSRDSPT GSSGSFSLCP GVTPSSILPG
ESSFSSSFVQ QKGQSQTWPD TSSPEVRQMH LESPSLQSKS QTSPKGGLSR SSSPVTELTA
RSPVKQDKSE LSTDPKLKSG MSPEQNKTKP DSSLYPLVDS KSLLVQSRLE PSELKERLGL
IEEDVASSCV LRDKFSPTQD RPESSTVLKD TPRVLLKERS GAGSPPGTRD QKILLPNSSQ
DELMEVEKSE QPLSQVLPTL SPEHKEMSAS NFESSPEIEE SPAVLSTLDQ SQSQPSKAAE
IPAVASCWVG PQVSPEHKEL SHSPPRDNSF ESLEFRNSGP VLEVNTDFSP EVKEELNGPF
LNQTETDPSL DMKEQSTRSS RRSSSELSPE IVEKVGIFSS QSVSSPLLET VQQRTPSRER
SSSVSSPELK DGLPRTPSRR SRSGSSPRLR DGSGTPSRHS LSGSSPGIKE TPQTPSRGRS
ECDSSPEPKA LPQTPRARSH SPSSPERNNK SVTPQRERSG SESSVEQKTL TRTSPGQRSR
SGSSQELDGK PSVSPQERSE SDSSPDSKPK ARTPLRQRSH SGSSPEVDSK SRHSPRLSRS
GSSPEMKEKS RVLQRAQSGT DSSPEHKIPA PRALPRRSRS GSSSKERGPS PEGSSSSESS
PEHPPKSRTA RRGSRSSVEP KTKSRTPPRR RSSRSSPELT RKARVSRRSR SASSSPETRS
RTPPRRRRSP SVSSPEPTEK SRSSRRRRSV SSPRNKTTSR RGRSPSPKPR GLQRSRSRSR
REKTRTTRRR DRSGSSQSTS RRRQRSRSRS RVTRRRRGGS GYHSRSPTRQ ESSRTSSRRR
RGRSRTPLTS RKRSRSRTSP APWKRSRSRA SPATHRRSRS RTPLISRRRS RSRTSPVSRR
RSRSVNRRRS RSRASPVSRR RSRSRTPPVT RRRSRSRTPT TRRRSRSRTP PVTRRRSRSR
SPPVTRRRSR SRTSPVTRRR SRSRTSPVTR RRSRSRTSPV TRRRSRSRTS PVTRRRSRSR
TPPAIRRRSR SRTPLLPRKR SRSRSPLAIR RRSRSRTPRA ARGKRSLTRS PPAIRRRSAS
GSSSDRSRSA TPPATRNHSG SRTPPVALSS SRMSCFSRPS MSPTPLDRCR SPGMLEPLGS
ARTPMSVLQQ TGGSMMDGPG PRIPDHPRSS VPENHAQSRI ALALTAISLG TARPPPSMSA
AGLAARMSQV PAPVPLMSLR TAPAANLASR IPAASAAAMN LASARTSAIP ASVNLADSRT
PAAAAAMNLA SPRTAVAPSA VNLADPRTPA ASAVNLAGAR TPAALAALSL TGSGTPPTAG
NYPSSSRTPQ APTPANLVGP RSAHGTAPVN IAGSRTPAAL APTNLSSSRM APALSGANLT
SPRVPLSAYE RVSGRTSPLL LDRARSRTPP SAPSQSRMTS ERERAPSPAS RMVQAPSQSL
LPPAQDRPRS PVPSAFSDQS RSIAQTTPVA GSQSLSSGTV AKSTSSASDH NGMLSGPAPG
VSHAEGGEPH ASTGAQQPSA LAVLQPAKER RSSSSSSSSS SSSSSSSSSS SSSSSSGSSS
SDSEGSSLPA QPEVALKRVP SPTPVPKEAV REGRPQEPTP AKRKRRSSSS SSSSSSSSSS
SSSSSSSSSS SSSSSSSSSS SSSSSSSSPS PAKPGPQALP KPASPKKPPP GERRSRSPRK
PIDSLRDSRS LSYSPVERRQ PSPQPSPRDQ QSSERVSWRG QRGDSHSPGH KRRKETPSPR
SNRHRSSRCV PYKSGPSES
//
