ID A0A0G2K3S4_RAT Unreviewed; 1653 AA.
AC A0A0G2K3S4;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=ATP binding cassette subfamily A member 9 {ECO:0000313|Ensembl:ENSRNOP00000072754.2};
GN Name=Abca9 {ECO:0000313|Ensembl:ENSRNOP00000072754.2,
GN ECO:0000313|RGD:1305931};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000072754.2, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000072754.2, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000072754.2,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0007829|PubMed:22673903}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [3] {ECO:0000313|Ensembl:ENSRNOP00000072754.2}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000072754.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_017459655.1; XM_017604166.1.
DR AlphaFoldDB; A0A0G2K3S4; -.
DR STRING; 10116.ENSRNOP00000072754; -.
DR PaxDb; 10116-ENSRNOP00000005775; -.
DR Ensembl; ENSRNOT00000087502.2; ENSRNOP00000072754.2; ENSRNOG00000059326.2.
DR AGR; RGD:1305931; -.
DR RGD; 1305931; Abca9.
DR VEuPathDB; HostDB:ENSRNOG00000059326; -.
DR eggNOG; KOG0059; Eukaryota.
DR GeneTree; ENSGT00940000162444; -.
DR InParanoid; A0A0G2K3S4; -.
DR OMA; FTTGMAQ; -.
DR Reactome; R-RNO-1369062; ABC transporters in lipid homeostasis.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000059326; Expressed in esophagus and 17 other cell types or tissues.
DR ExpressionAtlas; A0A0G2K3S4; baseline.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229:SF120; ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 9; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 255..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 387..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1055..1073
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1093..1113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1133..1154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1166..1183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1190..1212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1232..1252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 511..746
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1317..1550
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1633..1653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1653 AA; 186606 MW; 73C1F42B7FAE9A37 CRC64;
MKFLKISASA FLRTFTSTSL KSFKKNKQVK MRKRRLRLGQ QMWALLCKNW LRKFRMRRET
LLEWLLSFLL ILLAYQLSSN LHQVHDAPEM SMMDLGRVDD FNDSNYIIVF APESETTHEI
MNIAALAPFM KGRTIVACPD ESSMSELNLN YSIDAVRVIF KDTFSYHLKF SWGQRIPKTK
EHKDHTAPCE PFKNKMVCEN SVFWEKGFVA FQTAINAGII EVTTNHSVME ELMSVIGSVM
KMQPFIAQGG VATDFFIFFC VISFSSFIYY LSVNVTQERQ SITTLMAMMG LRESAFWLSW
GLMYAGFILV VATLMSLIVK STQVVVLTGF MVVFLLFLLY GLSLITLSFL MSVLLKKPFL
TGLAVFLLTV FWGSLGFTAL YKHLPAFMEW ILCFLSPFAF INGMAQLIHL DYDVNSNVNL
NSPNNSYLIL ATLFMLVLDA LLYLALALYF DKILLSKYGH QRSPLFFLKS SYWFQRRGAD
HVVLENEIDS APSLNDSLEP VSPEFQGKEA IRIKNLRKEY TGKHGKVEAL RGLGFDIYEG
QITALLGHSG AGKTTLINTL SGLSPPTTGS ITIYNQTVSE TEDSYAVPKL TGVCPQSNIQ
FGFLTVQENL RLFAKIKGIL PQEVEQEVRQ VLRDLEMENI QDTLAQNLSG GQKRKLTFGI
AILGDPQVLL LDEPTAGLDP LSRHHIWNLL KERRSGRVIV FSTQFMDEAD ILADRKVFIS
NGRLRCAGSS LFLKKKWGIG YHLSLHLNET CDPESITSLV KKHIPDARLT AQSDEQLVYI
LPLERTNKFP DLYRDLDRCS NHGIEDYDVS MTTLNEVFLK LEGKSMAEEP DAGVCGRLLS
DGAKDVESLV ELERVLPLDS SGSSVSGMAL WRQQLCAVAK VRFLKLKNER RSLMTMLLLF
GISFVPQLLE HLVYKVYHKS YSWGLSPSMY FLSPGQLPQD PLTHLLVINK TGSSIDNFIH
SLRQQGIALD VDALGTRNGK EEALYNGAVT VLGDEKDLRF SVACNAKRLN CFPVLADILS
NGLLGIFNSS ERIQTDRSTV FEDHMLYEYG FMSNAFFWIP VAASLTPYIA MGSISDHKKK
VLSQLWTSGL YPSAYWCGQA LVDIPIYFLI LLLMQIMDSV FSSEEIMSVI ESLLIQIPCS
IGYASSLIFL TYVISFVFRN GRKNSGIWSF FFLIVTIFFI VATDINEYGF LQLLFCTLLI
PPFTLIGSLL IFSEVSYDSV DYLGSSESQL VFLALLIPYL HFLLFFFILR CLERYIRKKT
LRVDPVFRIS PRSCRAFPNP EDPGEEDEDV QMERVRTSGA MTTPQMDEKP VIIASCLRKE
YTVKTKRCFS KTKKKIATRN ISFCVKKGEV LGLLGHNGAG KSTTISMITG DTVPTAGQVF
LKGSSGSAAL GFLGYCPQEN VLWPNLTVKE HLEVYAAVKG LRKKEAIVTI TRLVNALKLQ
DQLKALVKTL SEGVKRKLCF VLSILGNPSV VLLDEPSTGM DPEGQQQMWQ AIRATFTNTE
RGALLTTHYM AEAEAVCDRV AIMVSGRLRC IGSIQHLKSK FGKDYLLEMK LKTPALVESL
NTEILRLFPQ AARQERYSSL MVYKLPVEDV RPLSEAFFKL ERLKENFDLE EYSLSQSTLE
QVFLELSKEQ ELGDFDEEGS SSVKWKLLPQ EEL
//
