ID A0A0G3CUZ3_9GAMM Unreviewed; 616 AA.
AC A0A0G3CUZ3;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Chaperone protein HscA {ECO:0000256|ARBA:ARBA00018474, ECO:0000256|HAMAP-Rule:MF_00679};
DE AltName: Full=Hsc66 {ECO:0000256|HAMAP-Rule:MF_00679};
GN Name=hscA {ECO:0000256|HAMAP-Rule:MF_00679,
GN ECO:0000313|EMBL:AKJ42982.1};
GN ORFNames=QQ39_13660 {ECO:0000313|EMBL:AKJ42982.1};
OS Pragia fontium.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Budviciaceae; Pragia.
OX NCBI_TaxID=82985 {ECO:0000313|EMBL:AKJ42982.1, ECO:0000313|Proteomes:UP000068021};
RN [1] {ECO:0000313|EMBL:AKJ42982.1, ECO:0000313|Proteomes:UP000068021}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=24613 {ECO:0000313|EMBL:AKJ42982.1,
RC ECO:0000313|Proteomes:UP000068021};
RX PubMed=26159528;
RA Snopkova K., Sedlar K., Bosak J., Chaloupkova E., Provaznik I., Smajs D.;
RT "Complete Genome Sequence of Pragia fontium 24613, an Environmental
RT Bacterium from the Family Enterobacteriaceae.";
RL Genome Announc. 3:e00740-15(2015).
CC -!- FUNCTION: Chaperone involved in the maturation of iron-sulfur cluster-
CC containing proteins. Has a low intrinsic ATPase activity which is
CC markedly stimulated by HscB. Involved in the maturation of IscU.
CC {ECO:0000256|ARBA:ARBA00025329, ECO:0000256|HAMAP-Rule:MF_00679}.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000256|ARBA:ARBA00007381, ECO:0000256|HAMAP-Rule:MF_00679,
CC ECO:0000256|RuleBase:RU003322}.
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DR EMBL; CP010423; AKJ42982.1; -; Genomic_DNA.
DR RefSeq; WP_047781716.1; NZ_CP010423.1.
DR AlphaFoldDB; A0A0G3CUZ3; -.
DR STRING; 82985.QQ39_13660; -.
DR KEGG; pfq:QQ39_13660; -.
DR PATRIC; fig|82985.3.peg.2846; -.
DR OrthoDB; 9766019at2; -.
DR Proteomes; UP000068021; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:UniProtKB-UniRule.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR CDD; cd10236; HscA_like_NBD; 1.
DR Gene3D; 1.20.1270.10; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR HAMAP; MF_00679; HscA; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR042039; HscA_NBD.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR InterPro; IPR010236; ISC_FeS_clus_asmbl_HscA.
DR NCBIfam; TIGR01991; HscA; 1.
DR PANTHER; PTHR19375:SF176; CHAPERONE PROTEIN HSCA; 1.
DR PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR Pfam; PF00012; HSP70; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF100934; Heat shock protein 70kD (HSP70), C-terminal subdomain; 1.
DR SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR PROSITE; PS00297; HSP70_1; 1.
DR PROSITE; PS00329; HSP70_2; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00679};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|HAMAP-Rule:MF_00679};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00679}; Reference proteome {ECO:0000313|Proteomes:UP000068021}.
SQ SEQUENCE 616 AA; 65491 MW; 9D5444866DE8DCD7 CRC64;
MALLQISEPG MTAAPHQRRL AAGIDLGTTN SLVATVRSGQ AETLPDEQGR HLLPSVVHYQ
TDGIDVGWNA RAQAAVDPAN TLSSVKRMMG RSLDDIIQRY PNLPYQLSPS ENGLPTITTR
VGVVNPVQVS AEILSALAKR AQETLSGDLE GVVITVPAYF DDAQRQGTKD AARLAGLHVL
RLLNEPTAAA IAYGLDSGQE GIIAVYDLGG GTFDISILRL SRGVFEVLAT GGDSALGGDD
FDHLLADWLR EQAGFGAHHD HQLQRKLLDA AIAAKIALSM SDSTQVSVDG WQGTVTREQF
DSLIASLVKK TLLASRRALK DAGVTADEVL EVVMVGGSTR VPLVRTMVGE FFGRTPLTSI
DPDRVVAIGA AIQADVLVGN KPDSDLLLLD VIPLSLGIET MGGLVEKIIP RNTTIPVARA
QEFTTFKDGQ TAMMVHVLQG ERELVDDCRS LARFTLRGLP PMPAGGAHIR ITYQVDADGL
LSVTAMEKST NVQASIQVKP SYGLSDDEIA TMIKDSMANA QQDISARMLA EQKVEAARVL
ESLKAALSSD SDLLSGAELA EINRVVSQLE TSAQGNDASA IEAAIKNVDS ATQDFAARRM
DSSIRSALAG HSVDEV
//
