ID A0A0G3GVJ3_9CORY Unreviewed; 1115 AA.
AC A0A0G3GVJ3;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN Name=uvrD {ECO:0000313|EMBL:AKK05149.1};
GN ORFNames=CMUST_04025 {ECO:0000313|EMBL:AKK05149.1};
OS Corynebacterium mustelae.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=571915 {ECO:0000313|EMBL:AKK05149.1, ECO:0000313|Proteomes:UP000035199};
RN [1] {ECO:0000313|EMBL:AKK05149.1, ECO:0000313|Proteomes:UP000035199}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45274 {ECO:0000313|EMBL:AKK05149.1,
RC ECO:0000313|Proteomes:UP000035199};
RX PubMed=26358597;
RA Ruckert C., Eimer J., Winkler A., Tauch A.;
RT "Complete Genome Sequence of the Type Strain Corynebacterium mustelae DSM
RT 45274, Isolated from Various Tissues of a Male Ferret with Lethal Sepsis.";
RL Genome Announc. 3:e01012-15(2015).
RN [2] {ECO:0000313|Proteomes:UP000035199}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45274 {ECO:0000313|Proteomes:UP000035199};
RA Ruckert C., Albersmeier A., Winkler A., Tauch A.;
RT "Complete genome sequence of Corynebacterium mustelae DSM 45274, isolated
RT from various tissues of a male ferret with lethal sepsis.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP011542; AKK05149.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G3GVJ3; -.
DR STRING; 571915.CMUST_04025; -.
DR KEGG; cmv:CMUST_04025; -.
DR PATRIC; fig|571915.4.peg.860; -.
DR OrthoDB; 5240387at2; -.
DR Proteomes; UP000035199; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF59; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000035199}.
FT DOMAIN 38..333
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 297..611
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 59..66
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1115 AA; 121789 MW; CEE90B40DB375042 CRC64;
MDKTQAYDHT RVEGTDLEEI ALPIGAVRVQ LVRPESHNPQ REWDNPLFSE QQGVWRLIGS
AGTGVSSLLL DTIAHRIASG ERPENILVIA ASKQAASRLR RGIVARVAGD SYRSASTMVR
SIHSLAFALL RSSKKENLRL ITGAEQDAVI RELLAGHIEM RMPRWPEQCR EAIGMVGFAR
GLRDFLLRAV ERGLSPEDLE ELGHSYDRPM WSAAGEFLRE YEQIMALGGT HSLSASELVS
MVLETELPDT NFTTIIVDDA QHLDPKSAEL VAQLIQRASF AVIAGDPEQS VYRFRGARPT
FLTDYPVDNE LKLHIPHRIV AQPGAAGVEY RELESVGQQQ EVVADIIRRA HLIDGVAWKD
IAVVVRSVGM IASIRRGLLA AGVPVHIDPT DIVLSQQHIV AALLLAVRAV REKITPSELE
ELVLGPIGGA DAVTLRRLFR ALRKVELRYH RASSETADMP SRPMMRRAID ILADIVLDAE
PDPDFLADVT AELTQRELDI LSRIRTVLAA GRQPGSVEEI LWNIWSATNL DRHLLAVSLR
GGAAGSQADR DLDSVMALFD AAGDWVERRP TASIDSFIAH IREQELPTGV RDRRLATPEA
VSIVTAHATS GQQWDTVVVC GVQEGQWPSL GETGTLFGQE ELVDLIDDGI EPGTPISRAA
ERLAEERRLF HMATSRATRA LFITAVDAPD AEEALEPSRF VREFAEYNAA VAEHDNHAGQ
ALTADTNETI TSQPADETTA KAPNLVEATR PHQGDLFELL DAVDTETTPD AGKAVGLAEP
VDSYTTRLLS VPAIVAELRR ALINPQVNQR AKDQAARQLA RLADAGIPGA DPTQWWGIAD
SSETTKLTVK RLSPSRIEAG LECPLRATLH QVLTDEETPI ALLRGTLLHA FAEAIATGAD
VDAAREAIIT AFDSIVKAPQ WLKEHEIHVW KDALDRTALW LQTTRAVFEQ VGVEIAANVQ
LPNGVQLVGR IDRLEKTDDG GYHIVDFKSG INRPTKDETQ NHVQLMAYQL ALRHGQLTDT
DAAIVSGSGI KVDGASLVYP EKPGKTIATV TQASKSDAEL AEFAAALPPL VEELSGPVLR
ATTNRHCRSC QLSVLCPARD TGQWLTHPTT GTTET
//
