ID   A0A0G4EKG1_VITBC        Unreviewed;       301 AA.
AC   A0A0G4EKG1;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=NADP-dependent oxidoreductase domain-containing protein {ECO:0000259|Pfam:PF00248};
GN   ORFNames=Vbra_20431 {ECO:0000313|EMBL:CEL97018.1};
OS   Vitrella brassicaformis (strain CCMP3155).
OC   Eukaryota; Sar; Alveolata; Colpodellida; Vitrellaceae; Vitrella.
OX   NCBI_TaxID=1169540 {ECO:0000313|EMBL:CEL97018.1, ECO:0000313|Proteomes:UP000041254};
RN   [1] {ECO:0000313|EMBL:CEL97018.1, ECO:0000313|Proteomes:UP000041254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhu J., Qi W., Song R.;
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CDMY01000252; CEL97018.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0G4EKG1; -.
DR   STRING; 1169540.A0A0G4EKG1; -.
DR   VEuPathDB; CryptoDB:Vbra_20431; -.
DR   InParanoid; A0A0G4EKG1; -.
DR   OMA; EIYLRWC; -.
DR   OrthoDB; 5305445at2759; -.
DR   PhylomeDB; A0A0G4EKG1; -.
DR   Proteomes; UP000041254; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR   PANTHER; PTHR11732:SF507; ALDO_KET_RED DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000041254}.
FT   DOMAIN          5..277
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   REGION          277..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        37
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         99
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            66
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   301 AA;  33805 MW;  E571590A21CE7C02 CRC64;
     MPAFGLGTWR SEPNKVTEAV ECALSNGYIH LDCAAVYNNE HEVGEGIARA LQAGKINRDK
     LWVTSKLWCT KFRPEDVKPA LQRTLNDLRL DYVDQYLPHW PCPMAPTDVY SDPMPKDEHG
     VIRVADVALT DMWRAMEKLV DEGLVKTLGM SNFNIEETKL ILDNCDIPPV VDQVECHPLF
     PQHALRDFLK SENIELVAYS PLGNVNTDGP TALTDPLICD LGNKYSKSPA QICLRWNLQR
     GVIVIPKSVT PSRVVENSKV FDLQLSADDM ARINNLSEHE GRGRRQINPD FRPGGAKVFK
     D
//