ID A0A0G4GWB4_VITBC Unreviewed; 1134 AA.
AC A0A0G4GWB4;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Calpain catalytic domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=Vbra_18875 {ECO:0000313|EMBL:CEM35265.1};
OS Vitrella brassicaformis (strain CCMP3155).
OC Eukaryota; Sar; Alveolata; Colpodellida; Vitrellaceae; Vitrella.
OX NCBI_TaxID=1169540 {ECO:0000313|EMBL:CEM35265.1, ECO:0000313|Proteomes:UP000041254};
RN [1] {ECO:0000313|EMBL:CEM35265.1, ECO:0000313|Proteomes:UP000041254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhu J., Qi W., Song R.;
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CDMY01000850; CEM35265.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G4GWB4; -.
DR STRING; 1169540.A0A0G4GWB4; -.
DR VEuPathDB; CryptoDB:Vbra_18875; -.
DR InParanoid; A0A0G4GWB4; -.
DR OrthoDB; 230045at2759; -.
DR PhylomeDB; A0A0G4GWB4; -.
DR Proteomes; UP000041254; Unassembled WGS sequence.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.380; -; 2.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR46143; CALPAIN-7; 1.
DR PANTHER; PTHR46143:SF1; CALPAIN-7; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR Pfam; PF14555; UBA_4; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
DR PROSITE; PS50030; UBA; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00239}; Protease {ECO:0000256|PROSITE-ProRule:PRU00239};
KW Reference proteome {ECO:0000313|Proteomes:UP000041254};
KW Thiol protease {ECO:0000256|PROSITE-ProRule:PRU00239}.
FT DOMAIN 155..197
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 275..647
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT REGION 1..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 688..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..479
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..705
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..726
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 330
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 565
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 585
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00239"
SQ SEQUENCE 1134 AA; 124278 MW; BC9AF63077D476BC CRC64;
MGACCSSQGA QQKATAKRTA GAATGGPAGA GAAAAAPAAA AGGPPSRPDD LSPPSEVRDI
ESSATASRGG TRKPPQEGRS ARPLESAPLP ASALPVSRLP VPSPDMNLSE ENGASKRGGD
DAEEDPSIFL EFSPRNASNR IDVFTHPEKP APLSDQDKER MVNQLINITH LDRGEALSAL
ESCNFDIDEA VGFALAAGAS PAMAGASRSE LAKRQNQILP SHLKRSQTVS EILLESSIVG
QYVMLPWNEA DADIRHNFYY EQAASDERRR GARLPNSELF TDPEGQITLS TRQQQRFHEW
RRVRNAINEP VIVLDRPSSQ CIRQGFVGDC SFLSSLSVLA EFENKSSIPV LTGLLYPQVS
HSDANRILPV INPKGMYACR LYFNGVPRRV VIDDHVPVRR DGKLLAAHSS NKREVWVTLL
EKAFVKMMGG SYFMQGSNPG SDLYHLTGWI PETIPFKADV HIEGEDPQPH PHPHQHQHQH
ADQSIAATNG HGGVGTNGGG YNFSSGERID GRSPKWLRVW GELSSGLAEM RCVACLGTSD
VEDAAPSGLD YPEGVSISSG IVARHAYSVL GCREVGGHRL LYVKNPWGCI RWKGKFAPGD
NISWTPQMRR ALDYDPETQA SYDNGCFWIE WNDIVQWFSH LYICWNATCF PYQSEAHSRW
DRSSHLAQSC LADDSHLVAF NPQFHLRIHP PSIDPNRRRP PPDSRPSDAP HSTNTGGGQD
NSSSSSREDF FSEEVEVWIL LSRHVRERKK ALSQKYLAVH VHTGSERVTC PPPPAKQGVY
SNGECSLVKL RCLGNSEHSL KTLDYVLVVS QYSQKEDFNF TLKSYSHVHT TLQELPPMIP
DSWRSQYITG EWVKETAGGC SNDLWKYFMN PHYRIHMPEA AEVVIFLECP VEHSVNVRIF
RSAFASPRLL RTGKALSSGP YRAGCCTVKE KLEKGLHTIV LSTFRHGETG AYQLCVHSPY
FPGRLFPLPV VTPLPWPHVC PPPPPIEYVT FVYPDTGGGA GGAATFRQRY AIRTTQTTLV
SLRLQVVELS PPDAMPSMVL SKQRGGPSGP GSLVTIKKSD LEGGLSDDGR TTSSAATNLY
QEQRVVTLTL AELEPTRDDS TVVLDVGSTL GEAAVGSFVL YIYTDVPVNA SPVK
//
