ID A0A0G9F6G3_LACPN Unreviewed; 383 AA.
AC A0A0G9F6G3;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Foldase {ECO:0000313|EMBL:APD02230.1};
DE SubName: Full=Guanosine monophosphate reductase {ECO:0000313|EMBL:AOB22725.1};
DE SubName: Full=IMP dehydrogenase {ECO:0000313|EMBL:ODO62875.1};
DE SubName: Full=Inosine-5'-monophosphate dehydrogenase {ECO:0000313|EMBL:KZU92960.1, ECO:0000313|EMBL:QHM37266.1};
DE EC=1.1.1.205 {ECO:0000313|EMBL:ODO62875.1, ECO:0000313|EMBL:QHM37266.1};
DE SubName: Full=Inosine-5-monophosphate dehydrogenase {ECO:0000313|EMBL:BBA82314.1};
GN Name=guaB {ECO:0000313|EMBL:QHM37266.1};
GN ORFNames=ASV54_13050 {ECO:0000313|EMBL:APD02230.1}, AVR83_07110
GN {ECO:0000313|EMBL:AOB22725.1}, C7M36_01541
GN {ECO:0000313|EMBL:QHM37266.1}, C7M40_02474
GN {ECO:0000313|EMBL:QHM50504.1}, Lp19_2663
GN {ECO:0000313|EMBL:KZU92960.1}, LPJSA22_02893
GN {ECO:0000313|EMBL:ODO62875.1}, LpLQ80_13680
GN {ECO:0000313|EMBL:AWI41515.1}, SN35N_1935
GN {ECO:0000313|EMBL:BBA82314.1};
OS Lactiplantibacillus plantarum (Lactobacillus plantarum).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactiplantibacillus.
OX NCBI_TaxID=1590 {ECO:0000313|EMBL:ODO62875.1, ECO:0000313|Proteomes:UP000094892};
RN [1] {ECO:0000313|Proteomes:UP000183026}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MF1298 {ECO:0000313|Proteomes:UP000183026};
RA McLeod A., Rud I., Axelsson L.;
RT "Genome sequence of Lactobacillus plantarum MF1298, a candidate probiotic
RT associated with unfavorable effect.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AOB22725.1, ECO:0000313|Proteomes:UP000093296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DF {ECO:0000313|EMBL:AOB22725.1,
RC ECO:0000313|Proteomes:UP000093296};
RA Petkau K., Fast D., Duggal A., Foley E.;
RT "Comparative evaluation of the genomes of common bacterial members of the
RT Drosophila intestinal community.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KZU92960.1, ECO:0000313|Proteomes:UP000076882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=19.1 {ECO:0000313|EMBL:KZU92960.1,
RC ECO:0000313|Proteomes:UP000076882};
RA Martino M.E.;
RT "Comparative genomics of 54 Lactobacillus plantarum strains reveals genomic
RT uncoupling from niche constraints.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:ODO62875.1, ECO:0000313|Proteomes:UP000094892}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JSA22 {ECO:0000313|EMBL:ODO62875.1,
RC ECO:0000313|Proteomes:UP000094892};
RA Choi H.S.;
RT "Genome sequencing of Lactobacillus plantarum JSA22, isolated from
RT fermented soybean paste.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:BBA82314.1, ECO:0000313|Proteomes:UP000269784}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SN35N {ECO:0000313|EMBL:BBA82314.1,
RC ECO:0000313|Proteomes:UP000269784};
RX PubMed=29607926; DOI=.1248/bpb.b17-00840;
RA Noda M., Shiraga M., Kumagai T., Danshiitsoodol N., Sugiyama M.;
RT "Characterization of the SN35N Strain-Specific Exopolysaccharide Encoded in
RT the Whole Circular Genome of a Plant-Derived Lactobacillus plantarum.";
RL Biol. Pharm. Bull. 41:536-545(2018).
RN [6] {ECO:0000313|EMBL:QHM37266.1, ECO:0000313|Proteomes:UP000464882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SRCM101167 {ECO:0000313|EMBL:QHM37266.1,
RC ECO:0000313|Proteomes:UP000464882};
RA Jeong D.-Y.;
RT "Lactobacillus plantatrum SRCM101167 having anti-virus activity species
RT isolated from Korea kimchi.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:QHM50504.1, ECO:0000313|Proteomes:UP000465032}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SRCM101518 {ECO:0000313|EMBL:QHM50504.1,
RC ECO:0000313|Proteomes:UP000465032};
RA Jeong D.-Y.;
RT "Lactobacillus plantatrum SRCM101518 having antimicrbial activity species
RT isolated from Korea kimchi.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:AWI41515.1, ECO:0000313|Proteomes:UP000244922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LQ80 {ECO:0000313|EMBL:AWI41515.1,
RC ECO:0000313|Proteomes:UP000244922};
RA Moriya N., Nakano K., Shiroma A., Shinzato M., Ashimine N., Minami M.,
RA Tamotsu H., Shimoji M., Nakanishi T., Ohki S., Teruya K., Satou K.,
RA Hirano T., Hagi T., Kobayashi M., Nomura M., Kimoto H.N., Tajima K.,
RA Cai Y., Suzuki C.;
RT "Complete Genome Sequence of Lactobacillus plantarum Strain LQ80 Selected
RT for Preparation of Fermented Liquid Feed for Pig.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:APD02230.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MF1298 {ECO:0000313|EMBL:APD02230.1};
RA McLeod A., Fagerlund A., Rud I., Axelsson L.;
RT "Genome sequence of Lactobacillus plantarum MF1298, a candidate probiotic
RT associated with unfavorable effect.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + IMP + NAD(+) = H(+) + NADH + XMP; Xref=Rhea:RHEA:11708,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57464,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58053;
CC EC=1.1.1.205; Evidence={ECO:0000256|ARBA:ARBA00024264};
CC -!- COFACTOR:
CC Name=K(+); Xref=ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00001958};
CC -!- SIMILARITY: Belongs to the IMPDH/GMPR family.
CC {ECO:0000256|ARBA:ARBA00005502}.
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DR EMBL; CP013753; AOB22725.1; -; Genomic_DNA.
DR EMBL; CP013149; APD02230.1; -; Genomic_DNA.
DR EMBL; CP028977; AWI41515.1; -; Genomic_DNA.
DR EMBL; AP018405; BBA82314.1; -; Genomic_DNA.
DR EMBL; LUXM01000037; KZU92960.1; -; Genomic_DNA.
DR EMBL; MCOL01000001; ODO62875.1; -; Genomic_DNA.
DR EMBL; CP028334; QHM37266.1; -; Genomic_DNA.
DR EMBL; CP028241; QHM50504.1; -; Genomic_DNA.
DR RefSeq; WP_003642427.1; NZ_WYDR01000005.1.
DR GeneID; 77216315; -.
DR KEGG; lpb:SH83_13335; -.
DR PATRIC; fig|1590.142.peg.2862; -.
DR OMA; MGYCGAK; -.
DR Proteomes; UP000076882; Unassembled WGS sequence.
DR Proteomes; UP000093296; Chromosome.
DR Proteomes; UP000094892; Unassembled WGS sequence.
DR Proteomes; UP000183026; Chromosome.
DR Proteomes; UP000244922; Chromosome.
DR Proteomes; UP000269784; Chromosome.
DR Proteomes; UP000464882; Chromosome.
DR Proteomes; UP000465032; Chromosome.
DR GO; GO:0003938; F:IMP dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006177; P:GMP biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00381; IMPDH; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 2.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR005990; IMP_DH.
DR InterPro; IPR015875; IMP_DH/GMP_Rdtase_CS.
DR InterPro; IPR001093; IMP_DH_GMPRt.
DR PANTHER; PTHR11911:SF111; INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11911; INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED; 1.
DR Pfam; PF00478; IMPDH; 1.
DR SMART; SM01240; IMPDH; 1.
DR SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 1.
DR PROSITE; PS00487; IMP_DH_GMP_RED; 1.
PE 3: Inferred from homology;
KW GMP biosynthesis {ECO:0000256|ARBA:ARBA00022749};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:ODO62875.1};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755}.
FT DOMAIN 12..368
FT /note="IMP dehydrogenase/GMP reductase"
FT /evidence="ECO:0000259|Pfam:PF00478"
SQ SEQUENCE 383 AA; 39906 MW; E2285BD3C7248EAD CRC64;
MSNWDTKFGK KGYTFDDVLL IPAESHVLPN EVNLGVKLAD NLQLNIPIIS AGMDTVSESA
MGIAMANQGG LAVIHKNLSI EAQAEEVKKI KAVVKDDDHP HAAVDANNHL LAVAAVGVTS
DTFDRAEALF AAGADAIVID TAHGHSAGVL RKIKEIRAHF PKQTLIAGNV ATAEGTRALF
EAGVDVVKVG IGPGSICTTR IVAGVGVPQL TAVYDSASVA REYGKAIIAD GGIKYSGDIV
KALAAGGNAV MLGSMLAGTA EAPGEVVFDD GRQYKFYRGM GSVGAMSQAH GSSDRYFQGG
VNEANKLVPE GVEGRVPFKG SVDDIIFQML GGLRSGMGYV GAKDIDALIE NAQFVEISGA
GLRESHPHEI QITKNAPNYS VNG
//
