ID A0A0H0XJI5_9SPHN Unreviewed; 1152 AA.
AC A0A0H0XJI5;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=AAV99_13410 {ECO:0000313|EMBL:KLI62778.1};
OS Aurantiacibacter marinus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Erythrobacteraceae; Aurantiacibacter.
OX NCBI_TaxID=874156 {ECO:0000313|EMBL:KLI62778.1, ECO:0000313|Proteomes:UP000053455};
RN [1] {ECO:0000313|EMBL:KLI62778.1, ECO:0000313|Proteomes:UP000053455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HWDM-33 {ECO:0000313|EMBL:KLI62778.1,
RC ECO:0000313|Proteomes:UP000053455};
RA Zhuang L., Liu Y., Shao Z.;
RT "The draft genome sequence of Erythrobacter marinus HWDM-33.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLI62778.1}.
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DR EMBL; LBHU01000005; KLI62778.1; -; Genomic_DNA.
DR RefSeq; WP_047094605.1; NZ_LDCP01000003.1.
DR AlphaFoldDB; A0A0H0XJI5; -.
DR STRING; 874156.GCA_001021555_02438; -.
DR PATRIC; fig|874156.12.peg.2765; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000053455; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014151; DNA_helicase_AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02784; addA_alphas; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000313|EMBL:KLI62778.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000053455}.
FT DOMAIN 5..497
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 524..795
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 945..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 26..33
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1152 AA; 125836 MW; 0BAB46174ADB1950 CRC64;
MSGKVFPLKD NQRDAVAPDD SVWLSASAGT GKTQVLSARV LRLLLTEGVS PDQILCLTFT
KAGAAEMATR VNEVLANWVR MKPEALAADL NAIGAKGDDA TIARARTLFA SVLDCPGGGL
RIDTIHAFAQ WLLSAFPEEA GLTPGTRPME DRDRILLAGR VLRELLLDWQ ESEPSAVEAL
EMLSLRMGPD GARGWLMRCA MARDAWFGPS AWQPPMQARV KQLLGLPADI TAYALAGECA
EGTPGIELIR QVMWSYDEWG TKSGQKFAGL IGEWLLGSPE ERFAGSGAFL GDLYNDKGLL
KYQGNLEKQN AAITALAEQV RLWLEQVAEK ATLLALVDII TPALEIGRKF AIGWDEAKQR
EGLVDFDDLI RRAATLLGDN DMSAWIRYKL DRRFDHVLVD EAQDTNQEQW AIIGALTDDF
FSGEGQKGDR QRTLFVVGDY KQAIFGFQGT SPENFRSARD SYASKLRARR ENAAQSRQNV
SARDLQELGL GRSYRTAQSV LTFVDAAIDA ITPAAFGLDR QPDPHEGDNR PGLVTLWKPV
PGKPEDADEE DGLEIRVSEP ERRMADALAK QVKGWIDNGF ALSKGKPRNA GPGDIMVLVR
KRKDLAGLIV ARLHAAGVPV AGVDRLRLGA PLAVKDLMAA IRFAAQPNDD LALACLLVSP
IFGWSQEQLL EHGYRPKDRR LWDHLRSSKH AEARAAADRL RDLLAQADFE PPQALLHWLL
VGPWRARAKL VARLGREAND PIDELLNAAL QFSAANTPSL QGFIYWFDAG DGELKREAEG
SGNEVRVMTV HGSKGLQAPI VILADACGDP DASRTSGLDL VEDKPGNEIG LTLPLPPLSG
DERVGRIAEA EEAVKASDRQ EHWRLLYVAM TRAEEALFVG GSLGKRETEP KPDSWYARLE
PLFGGDWLDD QHWGARMEHG ERGVPVEKRF QTDLSLPMVL PAWATRPVGE EPRPPRPLAP
SASTDEQGSD PPLPAEQAAI AARRGVLIHS LLERLPDVPP ALRAAGGRAW LERHGTGLDP
AEREDMLLRA LAVLDDPQWR ELFGPDALAE VPLVATVGEQ VIAGTADRLL VTESRIMVAD
FKTARRPPVS LESVPLSTLK QMGTYAAALA VIFPGREIEA AVLYTQTPRL IAIPAEVLSA
HHPSAKAQLG AD
//
