ID   A0A0H1B4B1_9EURO        Unreviewed;       530 AA.
AC   A0A0H1B4B1;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   22-FEB-2023, entry version 21.
DE   SubName: Full=Lysosomal acid lipase/cholesteryl ester hydrolase {ECO:0000313|EMBL:KLJ05888.1};
GN   ORFNames=EMPG_10689 {ECO:0000313|EMBL:KLJ05888.1};
OS   Blastomyces silverae.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX   NCBI_TaxID=2060906 {ECO:0000313|EMBL:KLJ05888.1, ECO:0000313|Proteomes:UP000053573};
RN   [1] {ECO:0000313|Proteomes:UP000053573}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 139 {ECO:0000313|Proteomes:UP000053573};
RX   PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA   Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA   Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA   Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA   Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA   Clay O.K., Klein B.S., Cuomo C.A.;
RT   "The dynamic genome and transcriptome of the human fungal pathogen
RT   Blastomyces and close relative Emmonsia.";
RL   PLoS Genet. 11:E1005493-E1005493(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KLJ05888.1}.
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DR   EMBL; LDEV01003422; KLJ05888.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0H1B4B1; -.
DR   STRING; 2060906.A0A0H1B4B1; -.
DR   OrthoDB; 5474043at2759; -.
DR   Proteomes; UP000053573; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR006693; AB_hydrolase_lipase.
DR   PANTHER; PTHR11005; LYSOSOMAL ACID LIPASE-RELATED; 1.
DR   PANTHER; PTHR11005:SF103; STEROL ESTERASE TGL1; 1.
DR   Pfam; PF04083; Abhydro_lipase; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:KLJ05888.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053573}.
FT   DOMAIN          84..149
FT                   /note="Partial AB-hydrolase lipase"
FT                   /evidence="ECO:0000259|Pfam:PF04083"
FT   REGION          455..530
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        462..480
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   530 AA;  59731 MW;  21EB359B3BB72AEB CRC64;
     MARVPFVGRL FWNEYLALFS SLVLISIEGL LHFITFCLPQ PIIQFCYRQS KVLFKVLASP
     QGRRVRALQT STSGNIARAS DFLELCSLWG YEAEEHVVQT DDGYLLGLHR LPRKKGENFS
     KVNANDGTRQ KPVVYLHHGL LMNSEVWVCL TDEERCLPFQ LVEKGYDVWF GNNRGNKYSK
     KSVSHAPSST AFWDFSMDEF AFHDIPDSIE YILSVTSQKS LSYIGFSQGT AQAFATLSIH
     PTLNQKINLF IALAPAMSPA GLSNGVVDAL MKASPNVLFL AFGRRSILSS TPMWQTILYP
     PIFVRIIDIS LSFLFNWSGV NINSDQKLAA YPHLYSFTST KSVVHWFQII RNKSFQMYDD
     DAGPSVSINN NNRYYKPAKF PTRNIKTPIV LVYGGRDSLV DIDVMLEELP SHTQAISISH
     YEHLDFLWAR DVADQAFPHV LDALRSHGVN HTGWPAEKPD YLVKENSPDS LHHDQDENEI
     PVDNSPPQFA LTEARIPRSG QHSHARSSGL PSYSDDERVK LANGNRGDGI
//