ID A0A0H1B7I1_9EURO Unreviewed; 1711 AA.
AC A0A0H1B7I1;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Bromo domain-containing protein {ECO:0000259|PROSITE:PS50014};
GN ORFNames=EMPG_17555 {ECO:0000313|EMBL:KLJ06947.1};
OS Blastomyces silverae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=2060906 {ECO:0000313|EMBL:KLJ06947.1, ECO:0000313|Proteomes:UP000053573};
RN [1] {ECO:0000313|Proteomes:UP000053573}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 139 {ECO:0000313|Proteomes:UP000053573};
RX PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA Clay O.K., Klein B.S., Cuomo C.A.;
RT "The dynamic genome and transcriptome of the human fungal pathogen
RT Blastomyces and close relative Emmonsia.";
RL PLoS Genet. 11:E1005493-E1005493(2015).
CC -!- SIMILARITY: Belongs to the AAA ATPase family.
CC {ECO:0000256|ARBA:ARBA00006914}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLJ06947.1}.
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DR EMBL; LDEV01002943; KLJ06947.1; -; Genomic_DNA.
DR STRING; 2060906.A0A0H1B7I1; -.
DR OrthoDB; 2783776at2759; -.
DR Proteomes; UP000053573; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd05491; Bromo_TBP7_like; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR045199; ATAD2-like.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23069; AAA DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR23069:SF0; TAT-BINDING HOMOLOG 7; 1.
DR Pfam; PF00004; AAA; 2.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00674; AAA; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Reference proteome {ECO:0000313|Proteomes:UP000053573}.
FT DOMAIN 1237..1279
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1125..1149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1366..1604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..32
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..48
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..80
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..122
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..251
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..392
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..488
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1128..1142
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1370..1515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1554..1587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1711 AA; 189438 MW; 3607CA5B3883D41A CRC64;
MPRTSKRTLE EIVLKSDSDD ADYSDSKPRP ARKSTTSKPK PKKRPTKRQR RNSMDDDDDE
SNILTSEDDM EIESEFDEDD PTLERNARGS IKRRAAKKPN YQLSSTSDEG EDELEEEDEE
EEDKREVKGK SRNTDKGRTT KRLLVKFPIA AQSNTTRPTR STRGRSASKE NPTPTEYQGT
RRNTRRTYNE TEDMVALTGS GRHVQTVRKA TRSPEALSRT RRGAAAPAHV PSKSTIDEEE
EISRQELQDE GDTVPADPVA SQIEIMESDQ HGDFEEDAPA VAASDNINPP PEAEEAEENS
QDKDVEMGGE GFVPESDQGG ENEEEEDEDE APRSIRNTRT SRKQNMPAET VEEANPPTRR
STRRSAARSS RQPEEDGSDF EPNDDEANDE DLSGSEPPQA SPRKDSQQNI DEAYESSNDR
RSRLRKRQSQ SQGHVESEAG ELAEELAELR PERRRRRAQN EIVYEDKPRR TRKSVDYRII
RPEITLPIED ENDVPSGSPS RRGRGGGSGW QRTLFSTYGP FGGAGGLPPL LGAPGTGAAG
GADSDSSDDD SGQRPMVGGM SGMTPTAGFA PGFNVAPGHA FAPDTAPGLS GTPANFGKVK
DKQALADSDP LGIDPNVNFD SVGGLQGHID QLKEMVALPL LYPEIFQRFH IVPPRGVLFH
GPPGTGKTLL ARALASSVSS EGRKVTFYMR KGADALSKWV GEAERQLRLL FDEARKTQPS
IIFFDEIDGL APVRSSKQEQ IHASIVSTLL ALMDGMDGRG QVIVIGATNR PDSIDPALRR
PGRFDREFYF PLPNIEARRA ILDIHTRGWD PPLPDEIKDE LAELTKGYGG ADLRALCTEA
ALTAVQRKYP QIYRSNEKLL IDPKKIEVSP KDFMMSIKKL VPSSERSASS GASPLPSIVE
PLLKAPLRDI KQILAGILPQ KKRLTALEEA QFEEPEDSAG FKKERMQQEF ETSRVFRPRL
LIRGNPGMGQ QYLAAALLHH FEGLHVQAFD LPTLISDSTR SPEASVVQLF TEVKRHKPSV
IYIPNVQTWY ETVGQTVIST FLGLLRSLPP TDPVLLLGVL EDDGDNIDTT MMRDLFGFSK
KNRFDLHAPE SLWRYEFFSN LIKYIKSAPP EFPDPENRKR RKLETLERAP PPPPPPPVPP
TRQEIKAQKK RDRYTLNALK IRIQPIMDEI KKYKKFRAGV IDEAQIGYLY EEEDPNIVTT
DIPLVHRTTF RPFEKDVDKH GVPGLRETVS GKFYYNLDIV TIEKRLSNGY YKRPKDFLAD
IKRIAKDARQ LGDQDRQLKA NELLSNVEVD IGNIEHTDPL LVAECEQVYL REVERERVAL
EKAKRAAGAD GVMAPPPIMN VPHGNTETSH QSSGPVVLGE PFASRHLSAH GEPTTPTRPS
HASTVTNGHG PGKTAGETGS RPPTSNGFVG ADGDVQMSNS DDVQPSERDN TQNSSFGQSA
QPRPPHSYTA PSQQLRQQSG LSNLSQKGTM TPMAPGSQPG DYTNDASTTQ TTSDKKHSGP
SYAHQINTQS SIGGSARHEY PDLNLYPDRL SGDEPLPDTQ QGESGAWGTP LTGIVDFANS
QPSLVNGSQS QSNFNNSNAS KLSQLDTQPP IPPFDGAGPR TTTTPRQARM QELLPGEGTQ
QQPHHPLPPF PPAAGKLIVD DRRLEALHQT FTQRTNGLSV EQLEQVNTSL MDCVWKMRGE
WNRVEVAEAV EQAFEEVLSD IQSMQDFAVI S
//
