ID A0A0H1B892_9EURO Unreviewed; 155 AA.
AC A0A0H1B892;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Multiprotein-bridging factor 1 {ECO:0000256|ARBA:ARBA00014317};
GN ORFNames=EMPG_11040 {ECO:0000313|EMBL:KLJ05461.1};
OS Blastomyces silverae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=2060906 {ECO:0000313|EMBL:KLJ05461.1, ECO:0000313|Proteomes:UP000053573};
RN [1] {ECO:0000313|Proteomes:UP000053573}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 139 {ECO:0000313|Proteomes:UP000053573};
RX PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA Clay O.K., Klein B.S., Cuomo C.A.;
RT "The dynamic genome and transcriptome of the human fungal pathogen
RT Blastomyces and close relative Emmonsia.";
RL PLoS Genet. 11:E1005493-E1005493(2015).
CC -!- FUNCTION: Transcriptional coactivator that stimulates GCN4-dependent
CC transcriptional activity by bridging the DNA-binding region of GCN4 and
CC TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved
CC in induction of the ribosome quality control (RQC) pathway; a pathway
CC that degrades nascent peptide chains during problematic translation.
CC Required to prevent stalled ribosomes from frameshifting.
CC {ECO:0000256|ARBA:ARBA00035107}.
CC -!- SIMILARITY: Belongs to the MBF1 family.
CC {ECO:0000256|ARBA:ARBA00009802}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLJ05461.1}.
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DR EMBL; LDEV01003616; KLJ05461.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0H1B892; -.
DR STRING; 2060906.A0A0H1B892; -.
DR OrthoDB; 120438at2759; -.
DR Proteomes; UP000053573; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd00093; HTH_XRE; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013729; MBF1_N.
DR PANTHER; PTHR10245:SF15; ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1; 1.
DR PANTHER; PTHR10245; ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1; 1.
DR Pfam; PF01381; HTH_3; 1.
DR Pfam; PF08523; MBF1; 1.
DR SMART; SM00530; HTH_XRE; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR PROSITE; PS50943; HTH_CROC1; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000053573};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 98..144
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000259|PROSITE:PS50943"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 155 AA; 16814 MW; B20AB8B0DB0542F2 CRC64;
MSEDWDSVTR IGSRARGGGG GLRETVVKGK SALNAAARSG AIIGTEKKYA TGNAASKPRV
EGQLLTKVDR SDDIIPLQAV GEEVGKAIMR RRNEEGFKMT QKELAVKCNT TPGIIADLEQ
NKKGADKKIL PRIENVLNIK LTGRDIGKEK FPKRK
//
