ID A0A0H1B9R0_9EURO Unreviewed; 699 AA.
AC A0A0H1B9R0;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Translocation protein SEC63 {ECO:0000313|EMBL:KLJ05966.1};
GN ORFNames=EMPG_10579 {ECO:0000313|EMBL:KLJ05966.1};
OS Blastomyces silverae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=2060906 {ECO:0000313|EMBL:KLJ05966.1, ECO:0000313|Proteomes:UP000053573};
RN [1] {ECO:0000313|Proteomes:UP000053573}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 139 {ECO:0000313|Proteomes:UP000053573};
RX PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA Clay O.K., Klein B.S., Cuomo C.A.;
RT "The dynamic genome and transcriptome of the human fungal pathogen
RT Blastomyces and close relative Emmonsia.";
RL PLoS Genet. 11:E1005493-E1005493(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLJ05966.1}.
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DR EMBL; LDEV01003351; KLJ05966.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0H1B9R0; -.
DR STRING; 2060906.A0A0H1B9R0; -.
DR OrthoDB; 1605at2759; -.
DR Proteomes; UP000053573; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR004179; Sec63-dom.
DR PANTHER; PTHR24075; SEC63 DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24075:SF0; TRANSLOCATION PROTEIN SEC63 HOMOLOG; 1.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF02889; Sec63; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 4: Predicted;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000053573};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 14..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 77..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 106..178
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT REGION 488..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..528
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..699
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 699 AA; 78176 MW; D3878051CF3309BE CRC64;
MSSTDYNYDE QGQFFPFFIL TLTSLVTLPL TYTLLKPSDD LENTAPRIKS DFRPQHGDII
QKQKQKLLRK ERRLKRIITV IGGYAVMAWM VYLIIVTARS TPKIWDPYEI LDISRSASEK
AISRHFKRLS RQFHPDKIRP DPAKNQTIES LNNYFVELTK AYKALTDEEI RNNYIQYGHP
DGKQSFSIGI ALPKFIVTEG NGKYVLLVYG LLLGVLLPYI VGKWWYGTQR YTKEKVLVAS
AGNIFREYKD DLVGGGIINA LSSGEEYKQM LRDEKAESGL AKVEKKILSD EDSAAPGTTL
SAKDRKVLAD LENASRRKAL ALLWAYLGRV ELDDPVLNEE KFGVAPTAFT LNDSFASIAL
AFGSLQPILG SFHMSQHLIQ AVRPGGSPLL QLPHFTPQIV RSIEGEHSRS HMSISQYMAL
SEQRRRKLSV GKDLLSEQQY ASAVSVAQQI PVLDVSKSFF KVVGERVVTP SSLVQLVVKA
RFIPPGSTNI PEVNERDLED IDPDEDDIGA NKSSAKNKNG KDDSENKIQP PLAHAPYFAR
DHSPRWYIFL ADSKQGRMAV PPFTFTTFDK PIFDKDGKPT FNVQTLKMQF QAPPQVGKFV
FSLHIVCDSY IGFDTVSEIT LDVEDLAKAA ALEEEDDISE PDEDSIAGQM QALKTGTAPP
RKKIAKKQVD DSSEDDESNT DGDADDTSET NTETDTDGE
//
