ID A0A0H5S5U2_BRUMA Unreviewed; 832 AA.
AC A0A0H5S5U2;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=BMA-CUL-3 {ECO:0000313|EMBL:CRZ23558.1};
DE SubName: Full=Cullin homolog 3, putative {ECO:0000313|WBParaSite:Bm7268b.1};
GN Name=Bma-cul-3 {ECO:0000313|EMBL:CRZ23558.1,
GN ECO:0000313|WBParaSite:Bm7268b.1};
GN ORFNames=BM_Bm7268 {ECO:0000313|EMBL:CRZ23558.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CRZ23558.1};
RN [1] {ECO:0000313|EMBL:CRZ23558.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ23558.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CRZ23558.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ23558.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm7268b.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR EMBL; LN856882; CRZ23558.1; -; Genomic_DNA.
DR STRING; 6279.A0A0H5S5U2; -.
DR EnsemblMetazoa; Bm7268b.1; Bm7268b.1; WBGene00227529.
DR WBParaSite; Bm7268b.1; Bm7268b.1; WBGene00227529.
DR OMA; MFKDMTI; -.
DR OrthoDB; 21270at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF168; CULLIN-3; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 445..700
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT REGION 46..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 832 AA; 96337 MW; 16F6DA3BFAACCB81 CRC64;
MEIVIIRDFS ANLRFFLVVH VKFWFTSKLT SHSHIVSLIS HKMNVSRMNR STPSRSTPNG
GGSGSGGPSG NKMRIRAFPT TMDEKYVQQT WDLLKRAIQE IQRKNNSGLS FEELYRNAYT
MVLHKHGDKL YSGLKQVVIE HLQTTVRNEV LAAINSSFLE VLNVAWQDHI IAMVMIRDIL
MYMDRVYVQQ QNVDPVYNLG LILFRDEIIR YGTLGDTLRN ILLKMIAAER GGEIINRIGV
KNACNMLVAL GVDSRRVYEE EFEEPFLRVS AEYYRAESQN FLLENCASVY VKKVEECLME
ESNRAKMYLD KGTEQKILDV LDEELINKHM MTIVEMDNSG VVHMLNNDRI HDLRRLYILL
KRVKKGLPTM TDCISRYLRR KGEFLVNESS DHEPGTSKNP IHYIQALLDL KNQFDHFLLD
AFDNDKTFKQ KIQSDFEYFL NLNPKSPEYL SLYMDDKLKK GMKLMNESEQ ESLQDKSMVL
FRFLQEKDVF ERYYKSHLAK RLLLQKSMSD DAEKAMVSKL KTECGCQFTS KLEGMFKDIE
LSNILMGDFR DYKERAEIAH DSVDITVRVL TSGYWPTQAA PDCVLPPVAA QAFESFRTFY
LSKHNGRKIS LNPMLGHADV KAVFYGTNAN AEELSQQESD LAGPSVAPRG KEEYKILTVS
TYQMCVLLRF NNKSKITFEE LAAETQIPDK ELKRSLLSLA MGKPTQRILC RKGHGREIEN
SDEFWVNDAF TSKLTRIKIQ MVSGRAEAEP ERKETRSRID EDRKHEVEAA VVRVMKARKK
LLHNVLVAEV TQQLKHRFMP NPQLIKKRIE SLIERDYLAR DKNDHRCYEY VA
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