ID A0A0J0YUC0_9NEIS Unreviewed; 870 AA.
AC A0A0J0YUC0;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=PL75_01985 {ECO:0000313|EMBL:KLT73732.1};
OS Neisseria arctica.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=1470200 {ECO:0000313|EMBL:KLT73732.1, ECO:0000313|Proteomes:UP000036027};
RN [1] {ECO:0000313|EMBL:KLT73732.1, ECO:0000313|Proteomes:UP000036027}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KH1503 {ECO:0000313|EMBL:KLT73732.1,
RC ECO:0000313|Proteomes:UP000036027};
RA Hansen C.M., Hueffer K., Choi S.C.;
RT "Genome of a novel goose pathogen.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLT73732.1}.
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DR EMBL; JTDO01000002; KLT73732.1; -; Genomic_DNA.
DR RefSeq; WP_047760234.1; NZ_JTDO01000002.1.
DR AlphaFoldDB; A0A0J0YUC0; -.
DR STRING; 1470200.PL75_01985; -.
DR REBASE; 125141; M.Nsp1503ORF1985P.
DR PATRIC; fig|1470200.3.peg.1196; -.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000036027; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004546; Restrct_endonuc_T1M.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR NCBIfam; TIGR00497; hsdM; 1.
DR PANTHER; PTHR42933:SF1; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); 1.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000036027};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..127
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 162..470
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT COILED 666..693
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 870 AA; 97917 MW; ABAF1E4835D6BD69 CRC64;
MNKQQLASKI WQSANKMRSK IEANEYKDYI LGFIFYKFLS DKLEKFVLGE GLAKDDFADQ
LTEDGEFVDF IKDNIGYFIS YEHLFSTWLA QGSDFNIAHV RTAMSAFSRN IADNYTAVFD
GIFKTLESGL SKLGDTAASQ TNAVKDLFVL IADIPMDGKQ GYDVLGFIYE YLISMFAANA
GKKAGEFYTP HEVSLLMSEI IADHLKDREE ISIYDPTSGS GSLLINIGHS VAKHLKNANN
IKYYAQELKE NTYNLTRMNL VMRGILPSNI FTRNADTLED DWPLEGEPLY LDAVVSNPPY
SQPWNPKDKE SDPRYKRFGV APQTKADFAF LLHDLYHLKP DGMMTIVLPH GVLFRGGEEE
NIRKNLIEYN HIDAIIGLPA NIFFGTGIPT IIMVLRQERE RKDVLMIDAS KHFLKLGKNN
HLQASDIKRI VDCVTHRREL PKFSRVVSKE EIVANGYNLN IPRYVDSAEP AEQWDIFATM
NGGIPKSELA RFNDYWAAFN GLQAALFADN GTPYMQVKAE NLQTQIQNHP SVLAYKNQFA
ENFADFSDGL EKMLIEPMQT LNIAQTKGQL AELIRQKIAA MPLLDFYTAY QKLDDLWRAE
SAGIAADLEM IQTEGKQAIK QIDPYMVIKK DSKTKKEAEV QDGWVGHILP FELVQAVKLP
EQLSSLKTKE NRLTEITAEI QSLLENLSEE EKASSAVNDD GDSFVNAELP KALQQELEAC
GVIITKKADL AKAIEAHVFA EDSLGAKLQA AYRLLAAEKT LKTQIKTDSV QLHSDTKATI
ENLSDSEALD LLRQKWLAPL NEAMIRLPET MLAQFSQQLT ALCEKYAQTY QQISQEKAES
ANALAEMMNE LTGNEFDLQG ITAWQAILKA
//
