ID A0A0J7KF84_LASNI Unreviewed; 885 AA.
AC A0A0J7KF84;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Protein smoothened {ECO:0000313|EMBL:KMQ88927.1};
GN ORFNames=RF55_11510 {ECO:0000313|EMBL:KMQ88927.1};
OS Lasius niger (Black garden ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Lasius; Lasius.
OX NCBI_TaxID=67767 {ECO:0000313|EMBL:KMQ88927.1, ECO:0000313|Proteomes:UP000036403};
RN [1] {ECO:0000313|EMBL:KMQ88927.1, ECO:0000313|Proteomes:UP000036403}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole {ECO:0000313|EMBL:KMQ88927.1};
RA Konorov E.A., Nikitin M.A., Kirill M.V., Chang P.;
RT "Lasius niger genome sequencing.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KMQ88927.1}.
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DR EMBL; LBMM01008383; KMQ88927.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J7KF84; -.
DR STRING; 67767.A0A0J7KF84; -.
DR PaxDb; 67767-A0A0J7KF84; -.
DR OrthoDB; 2902735at2759; -.
DR Proteomes; UP000036403; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0032502; P:developmental process; IEA:UniProt.
DR CDD; cd07451; CRD_SMO; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 2.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR041771; SMO_CRD.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF35; SMOOTHENED HOMOLOG; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000036403};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..885
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005290294"
FT TRANSMEM 233..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 437..454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..181
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 231..417
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 594..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 682..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..615
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..714
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..730
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..775
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 885 AA; 100255 MW; B5BB02E4EDC57752 CRC64;
MISSLVFCCL LFHGSSSELE HELNSNNGEN NTWKDMDLSP RHRIKDSIYL DRYPIGELDV
STCRRPAKCV PLHKGTCMGT KLPYSSTTLD LIPERVTQDI IEERLYLLQA LKHVPKCWAV
VQPFLCSIFM PKCVNNTVEL PSQEMCKMVS GPCRMLINHT IWPSFAKCDN TKLFPRLCKN
DIRELKFNIT AKCLKPLVPT DNALSIFDGV EGCGTECYDP LYTTDEHNQI HSFIVWAAGI
CCTFNLFTVI TFLIDWRSAN KYPALVIFYI NGCFLVCCIG WLVQFTPSGR EVIICRKDGT
LRMREPSGEN LSCVVVFVLV YYFLMAAMVW FVILTYAWHM SFRALGTIQD RINKKSAYFH
LIAWCVPLVL TVAIMALGRI DGNSMTGICF VGYADHAAKA FVLGPVLIVV LVGGYFLCRD
VSDCKIDTRP STGKLQLHLL ALFSTGILMS SWVWTSSTVD TWCRFLRRIF NRESEEPPIR
LSKHKLIAHL FANRKTFNKA GRLSISFHNT HEDPVGLNFD LNSAASQDFS TTWAAALPKL
VTRRCALVGG TTGSVSSNRR NSADSEISYS FRCVSMESRR NSLDSQISVQ IAQVKTTRKV
ASRSRGRRGK NRRDFGKSRS SKIDPLSRRG STTSQDSQLM NQIPMVFPIQ MPNMGRRLGN
AGLDERSLKI IDTKDKGMLL PFLLGGQSGS DENLSSEEKR HRDMADKDVD IETGNMEKED
EQDSDSEDSQ LEEEVKMLDP EEVHERSKNK NSNKNCKTYE DDRRNREGSH RSKYLQDEAI
LKHLLQDSGD IKMKNENEKK EVYRKTVMDD MDSSHTSCYP ELTRLLQNDG PTNAREMATQ
TSLPLDILEM EELKQSIDEI INSRHCSSKG TQISPQLKKG KNIVT
//
