ID A0A0J7KYF5_LASNI Unreviewed; 1411 AA.
AC A0A0J7KYF5;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN ORFNames=RF55_4466 {ECO:0000313|EMBL:KMQ95329.1};
OS Lasius niger (Black garden ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Lasius; Lasius.
OX NCBI_TaxID=67767 {ECO:0000313|EMBL:KMQ95329.1, ECO:0000313|Proteomes:UP000036403};
RN [1] {ECO:0000313|EMBL:KMQ95329.1, ECO:0000313|Proteomes:UP000036403}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole {ECO:0000313|EMBL:KMQ95329.1};
RA Konorov E.A., Nikitin M.A., Kirill M.V., Chang P.;
RT "Lasius niger genome sequencing.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KMQ95329.1}.
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DR EMBL; LBMM01002057; KMQ95329.1; -; Genomic_DNA.
DR STRING; 67767.A0A0J7KYF5; -.
DR PaxDb; 67767-A0A0J7KYF5; -.
DR OrthoDB; 2875525at2759; -.
DR Proteomes; UP000036403; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0048666; P:neuron development; IEA:UniProt.
DR CDD; cd00063; FN3; 3.
DR CDD; cd00096; Ig; 1.
DR CDD; cd00047; PTPc; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF495; TYROSINE-PROTEIN PHOSPHATASE 69D; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000036403};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 766..789
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..73
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 79..173
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 178..273
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 275..371
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 375..486
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 852..1109
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1029..1100
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1141..1398
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1315..1389
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 680..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1411 AA; 159504 MW; 11EA2BFB8AB19F3C CRC64;
MEGIEAGSTP SLLCKLNVPG QVWWSTDGRN LTTIKDLEYA GRFDIKKASR NDTGDYKCSA
QTVDGESLEK NIHIRVIEPG KITSGGDVRA KVMEAANLTC HIHGYPLSQF TWLKGNDSES
SEHLKDITAV ARINETYAVL ILEFKSLARK DNGTYVCQAN DYNGMVSATA HLFVIDVPKV
SIDFMKAVGA GSIFLNWTVN DGNEPIKKYF IQHMKNGTDQ RQYYAEQIGG GNSSYVLKGF
ENGTAYQIGI SATNTVGASY MQLDPRWITT LEKDPVFVPK VSVNGVTETS ITIGWTVPPS
DLKEHVHYYN LMATHAEQKR EAVYPAEPLN VYMFMDLDPA TTYKFKIAAC SEYTKRCGNW
SAEVNGTTLD GVASPPKNLI VICRYDNISS SSFMSITWKP PEKPNGIIQR YNIQLNGVAK
FKNDMGRLDI DSFEPPNWSV YKKNSTRYNT IPPNTNYTVR VHGVTRSRAP GKDAVGNCTT
PVTVPDRDSM NLRTWRKIES QGRQLFKLYL PRISERNGPI CCYRIYVVKL PSQKTVRDLP
PPEEIAVYSY QYVHSSPTGG AYIVETFESD RLSSEIFLGD GESSIGGAMC DKCVGLRPKP
APPLLHFVPE IPLTTASANA NSTTTITTTT TFSPTTTASG SSSGSVIASS STASATTTIS
TAAKIDVTTA IPVIINATEK AERRKREDSP VQKASVDGST GESSMLSPYD GFLDETSNYT
GFIEVIVYDN QRDQFLPAYS SYFNPLYGGV DPLSVTAAEP TNINEMIIQL FIALLLTVMI
LCIALCILYR FTKRPQEREE VINLRNSFRH FCRSLRSRHQ LVAASPPDMP PIPKSELLQA
YLERHRDSDY GFQHEFELLP DRFTDRTTRA SEAQENLYKN RYPDIKCYDQ TRVRLAQMDG
ICGSDYINAN FVLGYKERKK FICAQGPMEN TVCDYWRMIW EQHLELILML TNLEEYSKTK
CAKYWPDKRE TKNFGDITVE HVKERAYSDY VVRELKMTRL GERDARAIVQ YHFLVWKDFV
APEHPHAILR FIKRVNEAYS LEKGPILVHC SAGVGRTGTL VALDSLLQQL AEESQVSIFN
TVCDLRHQRN FLVQSLKQYI FIYRSLMEMA QYGDTEIPAS QLKTTVAKLR QRDNGKEKCK
MEEEYDKISS VLEDRKSFSV GGGEENRSKN RSELVIPYDR NRVILTPVPG REHSTYINAS
FIEGYDNSES FVITQDPLET TVTDFWRMIS EQCISTIVML SDLNEGPRKC PRYWPDDETN
YDHIKVRYIH SESCPYYTRR EFNIVNTKTD ENGVVKQYQY HGWPTVEGEV PEVTRGLIEV
VDQTLTNDTE TSGSLVVHCS YGSDRSSMFV ALSILVQQLR TEKRVDIFTT TKKLRSQRHG
MISTFAQYEF LHRAIVNYSD LHNLADDESV S
//
