ID A0A0J7XZK5_9SPHN Unreviewed; 710 AA.
AC A0A0J7XZK5;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Flagellar biosynthesis protein FlhA {ECO:0000256|RuleBase:RU364093};
GN Name=flhA {ECO:0000256|RuleBase:RU364093,
GN ECO:0000313|EMBL:KMS57096.1};
GN ORFNames=V473_02265 {ECO:0000313|EMBL:KMS57096.1};
OS Sphingobium cupriresistens LL01.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingobium.
OX NCBI_TaxID=1420583 {ECO:0000313|EMBL:KMS57096.1, ECO:0000313|Proteomes:UP000052232};
RN [1] {ECO:0000313|EMBL:KMS57096.1, ECO:0000313|Proteomes:UP000052232}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LL01 {ECO:0000313|EMBL:KMS57096.1,
RC ECO:0000313|Proteomes:UP000052232};
RX PubMed=25850427; DOI=10.1534/g3.114.015933;
RA Pearce S.L., Oakeshott J.G., Pandey G.;
RT "Insights into Ongoing Evolution of the Hexachlorocyclohexane Catabolic
RT Pathway from Comparative Genomics of Ten Sphingomonadaceae Strains.";
RL G3 (Bethesda) 5:1081-1094(2015).
CC -!- FUNCTION: Required for formation of the rod structure of the flagellar
CC apparatus. Together with FliI and FliH, may constitute the export
CC apparatus of flagellin. {ECO:0000256|RuleBase:RU364093}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU364093};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU364093}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC pore) family. {ECO:0000256|ARBA:ARBA00008835,
CC ECO:0000256|RuleBase:RU364093}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KMS57096.1}.
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DR EMBL; JACT01000001; KMS57096.1; -; Genomic_DNA.
DR RefSeq; WP_066600013.1; NZ_KQ130434.1.
DR AlphaFoldDB; A0A0J7XZK5; -.
DR STRING; 1420583.V473_02265; -.
DR PATRIC; fig|1420583.3.peg.452; -.
DR Proteomes; UP000052232; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 3.40.30.60; FHIPEP family, domain 1; 1.
DR Gene3D; 1.10.8.540; FHIPEP family, domain 3; 1.
DR Gene3D; 3.40.50.12790; FHIPEP family, domain 4; 1.
DR InterPro; IPR042194; FHIPEP_1.
DR InterPro; IPR042193; FHIPEP_3.
DR InterPro; IPR042196; FHIPEP_4.
DR InterPro; IPR025505; FHIPEP_CS.
DR InterPro; IPR006301; FlhA.
DR InterPro; IPR001712; T3SS_FHIPEP.
DR NCBIfam; TIGR01398; FlhA; 1.
DR PANTHER; PTHR30161:SF1; FLAGELLAR BIOSYNTHESIS PROTEIN FLHA-RELATED; 1.
DR PANTHER; PTHR30161; FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED; 1.
DR Pfam; PF00771; FHIPEP; 1.
DR PIRSF; PIRSF005419; FlhA; 1.
DR PRINTS; PR00949; TYPE3IMAPROT.
DR PROSITE; PS00994; FHIPEP; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis {ECO:0000256|RuleBase:RU364093};
KW Bacterial flagellum protein export {ECO:0000256|RuleBase:RU364093};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU364093};
KW Cell projection {ECO:0000313|EMBL:KMS57096.1};
KW Cilium {ECO:0000313|EMBL:KMS57096.1};
KW Flagellum {ECO:0000313|EMBL:KMS57096.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364093};
KW Protein transport {ECO:0000256|RuleBase:RU364093};
KW Reference proteome {ECO:0000313|Proteomes:UP000052232};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364093};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364093}; Transport {ECO:0000256|RuleBase:RU364093}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 39..61
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 113..136
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 205..226
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 238..264
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 284..300
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT REGION 688..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..710
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 710 AA; 74842 MW; 983B6C688CC446B8 CRC64;
MSPAQVKAKI WMSAVKGAVL PFATLMVVVF MMVPVPAVML DIGFITNIMI SLAVLMVALN
AGKPLDFSSF PTVLLFATLL RLALNVASTR VVLVSGHEGS DAAGQVIEAF GHFLIGGDYV
VGIFVFAILM IINLVVITKG AGRVSEVSAR FTLDALPGKQ MAIDADLNAG LMTPEEAKQR
RVEVATEADF YGSMDGASKF VKGDAVAGIL ILVINIVGGI ILGVVSHGLA IGEAAQTYIV
LAIGDALVAQ IPALLLSIAA ASIVTRVKSE QDLGGQIAGQ FGSGRAWVPV AAILGFLGIL
PGMPHLIILS AAAIAGGIAW QLRKAVQKKA AEPAPVAPAP NPAVIEWDDV SDGAILGLEI
GYGLIALVDE RKGAPLMARI TGIRRQLSKE LGFVVPMVRV KDNLALEPNQ YRITIAGVVV
GEDEIWPDDL LALDSGALEG AVAGRPAKDP TFGLDAVWIS QAKRSEAVVA GYTVVDPPTV
VATHLNQLIA MNAAEMFGLD EARKLLDTLK DAAPQLVDGL TPGTLSLTQI SALCRALLSE
GIALKDFRRI CEAMVDAARP DMSHEQLVEA VRQRIGALII QGLVPVKMPL PVITLDGDLE
GLLAQAMRVA GDAKHPIEPA LANRIVEAVI HAARPLLGQA RNFAIVTSPV ARRALARLFK
PHLPETPILS FLEIPDGKGV EVVAVVGNEQ RPTPRHDPAP QREQARERVA
//
