ID A0A0J7ZLR3_STRVR Unreviewed; 605 AA.
AC A0A0J7ZLR3;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:KMS76864.1};
GN ORFNames=ACM01_03235 {ECO:0000313|EMBL:KMS76864.1};
OS Streptomyces viridochromogenes.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1938 {ECO:0000313|EMBL:KMS76864.1, ECO:0000313|Proteomes:UP000037432};
RN [1] {ECO:0000313|EMBL:KMS76864.1, ECO:0000313|Proteomes:UP000037432}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 3414 {ECO:0000313|EMBL:KMS76864.1,
RC ECO:0000313|Proteomes:UP000037432};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KMS76864.1}.
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DR EMBL; LFNT01000002; KMS76864.1; -; Genomic_DNA.
DR RefSeq; WP_048579459.1; NZ_LGUR01000117.1.
DR AlphaFoldDB; A0A0J7ZLR3; -.
DR PATRIC; fig|1938.3.peg.254; -.
DR OrthoDB; 9771883at2; -.
DR Proteomes; UP000037432; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 2.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 4: Predicted;
FT DOMAIN 19..197
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 200..296
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 326..503
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 506..602
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 605 AA; 63777 MW; 01DEA8639E7F2A30 CRC64;
MATPLSDPSS DTPLSPLRTV AVVGLGTMGT GIAEILAKAG REVIGIDISE AAAAKAVAAL
ESSTARAVER GRLTEEERAQ ALARVRTSAD LRAAADADLV IEVAPESYEI KQQIFRELDG
IVRPETILAT GTNALSVTRL AADSARPERV LGLHFFNPAP AMRLVEVVSS VLTAPTAVTA
VTNLALDLGK EPVAVGDRPG FVADGLLFGY LNQAAAMYEA KYASREDIDA AMRLGCGLPM
GPLALLDLIG IDTARRVLEA MYAESRDRLH APAPILKQLS EAGLTGRKSG RGFYTYEAPG
SATVVRDALT PLDGAALTPG RTVRSVGVAG SGTMASGIAE VFAKAGYEVV LAARSEEKAQ
AAKARIGKSL SRSVDKGRMT AEAAAQTLDL ITAAGSYDAF ADVDLAVEAV AEDLEIKRQL
FATLDKVCKP GAVLATTTSS LPVVACARAT SRPQDVIGMH FFNPAPAMKL VEVVRTVLTA
DDVHSTVREV CGRIRKHAVD CGDRAGFIVN ALLFPYLNNA IKMVQEHYAT LDDIDAAMKL
GGGYPMGPFE LLDVVGLDVS LAIEKVLHRE FRDPGLAPAP LLEHLVAAGC LGRKTGRGFR
EYARR
//
