ID A0A0J8QQU3_COCIT Unreviewed; 901 AA.
AC A0A0J8QQU3;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Replication factor C subunit 1 {ECO:0000256|PIRNR:PIRNR036578};
GN ORFNames=CISG_10132 {ECO:0000313|EMBL:KMU73608.1};
OS Coccidioides immitis RMSCC 3703.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=454286 {ECO:0000313|EMBL:KMU73608.1, ECO:0000313|Proteomes:UP000054559};
RN [1] {ECO:0000313|Proteomes:UP000054559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 3703 {ECO:0000313|Proteomes:UP000054559};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR036578}.
CC -!- SIMILARITY: Belongs to the activator 1 large subunit family.
CC {ECO:0000256|ARBA:ARBA00006116, ECO:0000256|PIRNR:PIRNR036578}.
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DR EMBL; DS268252; KMU73608.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J8QQU3; -.
DR STRING; 454286.A0A0J8QQU3; -.
DR Proteomes; UP000054559; Unassembled WGS sequence.
DR GO; GO:0005663; C:DNA replication factor C complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006271; P:DNA strand elongation involved in DNA replication; IEA:UniProt.
DR CDD; cd18140; HLD_clamp_RFC; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR013725; DNA_replication_fac_RFC1_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012178; RFC1.
DR InterPro; IPR047854; RFC_lid.
DR PANTHER; PTHR23389; CHROMOSOME TRANSMISSION FIDELITY FACTOR 18; 1.
DR PANTHER; PTHR23389:SF6; REPLICATION FACTOR C SUBUNIT 1; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF08519; RFC1; 1.
DR PIRSF; PIRSF036578; RFC1; 2.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR036578};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR036578};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR036578}; Nucleus {ECO:0000256|PIRNR:PIRNR036578};
KW Reference proteome {ECO:0000313|Proteomes:UP000054559}.
FT DOMAIN 318..375
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 1..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 806..901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..192
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 812..833
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..891
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 901 AA; 100131 MW; CE42A8CF73C1FDDA CRC64;
MAPDIRSFFG TQSSQGSKSG KGASSKKPED NSKLKKRRGR KVIEDSEDED VQPVKTTPKP
EPKKKRQKPE ETEEPTTTSD YFASSRKSLR GPKSSAPVEE SKPEKSEVSE AKSVDVTSKS
RKSDAKRDRE RSPAVVVRNG RTRQKPKATK ILDADDSLGG DDIFATEYQK RGGGGGDDDY
QEEEDEDSDF EELQVESRPL QPAKKVSRST NTSTRNGQKR KSDALHDEDE ESELSDKQKK
KAARGQAVKS PTKPTPKKQK AAAKPPQAES KEIQAIFDSI PTVRPPSPPA EAKKFNFMAA
NQRAHASAAG EPAELPIGAE NCLAGLSFVF TGVLDSLGRD EGQALVKRYG GKVTGAPSSK
TSYVVLGSDA GPKKLATIRK HNLKTINESK RLLEDGLRGV LDTTSLQGYF SGEGKKVQSE
KKNLVLIMDE VDGMSAGDRG GVGALAAVAK KTRIPMILIC NERRLPKMRP FDHVTYELPF
RRPTADQIRS RLATICFREG LKIPPQVLDG LIEGTHSDIR QIVNMLSTVK LDSQNLDFDE
GKQMSKAWEK HVILKPWDIV GKILSAQMFS QSSTATLNDK IELYFNDHEF SYLMLQENYL
KTNPIAAGSY NGRERKFKLL ELADNAAQSI SDGDLVDRMI HGSQQQWSLM PTHAVFSFVR
PASFVSGNMV DRVGFTSWLG NNSKQGKMAR QIKEIQGHMR LRASGDRHEI RQQYLPALWE
KLVHRLDVDG KDAVQEVIDL MDSYFLTRED WDSILELGLG PMSEKTVNIE SQTKATFTRL
YNQQSHPLPF MKASTVVAPK RLPKIKPDLE DAMDESDEGE EILGEEEVKE DDDELDLKKD
KYVRAPKKTG AKKATAGKGT AKPKKKRNKR KKSDSDLDIS DREEDSKPSK ARKGKKTKGK
A
//
