ID A0A0J9WH96_FUSO4 Unreviewed; 716 AA.
AC A0A0J9WH96;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Malate dehydrogenase (Oxaloacetate-decarboxylating)(NADP+) {ECO:0008006|Google:ProtNLM};
GN ORFNames=FOXG_01611 {ECO:0000313|EMBL:KNA96396.1};
OS Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935
OS / NRRL 34936) (Fusarium vascular wilt of tomato).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=426428 {ECO:0000313|EMBL:KNA96396.1, ECO:0000313|Proteomes:UP000009097};
RN [1] {ECO:0000313|EMBL:KNA96396.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=4287 {ECO:0000313|EMBL:KNA96396.1};
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Nusbaum C., Devon K., Ma L.-J., Jaffe D.,
RA Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.,
RA Brockman W., MacCallum I.A., Young S., LaButti K., DeCaprio D.,
RA Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C.,
RA Larson L., White J., O'Leary S., Kodira C., Zeng Q., Yandava C.,
RA Alvarado L., Kistler C., Shim W.-B., Kang S., Woloshuk C.;
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KNA96396.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4287 {ECO:0000313|EMBL:KNA96396.1};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
CC -!- SIMILARITY: Belongs to the malic enzymes family.
CC {ECO:0000256|ARBA:ARBA00008785}.
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DR EMBL; DS231697; KNA96396.1; -; Genomic_DNA.
DR RefSeq; XP_018234442.1; XM_018378507.1.
DR AlphaFoldDB; A0A0J9WH96; -.
DR SMR; A0A0J9WH96; -.
DR GeneID; 28943854; -.
DR KEGG; fox:FOXG_01611; -.
DR VEuPathDB; FungiDB:FOXG_01611; -.
DR OrthoDB; 1069499at2759; -.
DR Proteomes; UP000009097; Unassembled WGS sequence.
DR GO; GO:0004470; F:malic enzyme activity; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05312; NAD_bind_1_malic_enz; 1.
DR Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR012301; Malic_N_dom.
DR InterPro; IPR037062; Malic_N_dom_sf.
DR InterPro; IPR012302; Malic_NAD-bd.
DR InterPro; IPR001891; Malic_OxRdtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23406; MALIC ENZYME-RELATED; 1.
DR PANTHER; PTHR23406:SF32; NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL; 1.
DR Pfam; PF00390; malic; 1.
DR Pfam; PF03949; Malic_M; 1.
DR PRINTS; PR00072; MALOXRDTASE.
DR SMART; SM01274; malic; 1.
DR SMART; SM00919; Malic_M; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009097}.
FT DOMAIN 230..395
FT /note="Malic enzyme N-terminal"
FT /evidence="ECO:0000259|SMART:SM01274"
FT DOMAIN 405..672
FT /note="Malic enzyme NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00919"
FT REGION 36..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 716 AA; 79618 MW; E5C12F0A063C77A2 CRC64;
MGQTLSTMTV ASPSGPGSAQ NVLNRLFFAS GPLRSATSST LTRASTRSST VPPAVVLTAT
TNNRRPRPSN PRLSYSSFFP FSSPHLPLSM SMASSSPHST ASSEIATPRS RSSTTSSPRR
LTDSNPMSPV DLSKIEQEIK MAALDQHRGY VQDHYAEVKQ DRTPEYVDES NAAGYQIVRE
PLWNKGLAFT PEERASKNLT GLLPHTMESF ETQCARAMKM IQTRQTPIDK DQNTDLFYRL
LIDNIRELMP LVYTPTIGDV CLQYSSIYTR PEALYISIKQ RKSIRAMLRN WPCQDPEICV
VTMALASLVW IGKPALYTGA AGIHPSKTLP IVLDCGTQQR GEPERPLLPW RPSYPEQQAF
MDEFMEAARE VFPSMVVQFE DFDSEKAFGY LDRYRDQYRC FNDDIQGTGA VVLGGYIGAV
EQSGVPIEEQ RLVFMGAGSA GVGVAKQLVE YYTRRGLSEA AARDKFWLVD TKGLVTKDRG
DRLAEHKKYF ARTDNNGQQY RTLEEVIEYV KPSALVGLTA TFGVFTEPVV RALKHSVQEG
GLERRPILFP LSNPLTKAEC TFEQAIEWTE GTVLFASGSP FNPVKAKFGD ETHHTVYHPN
QGNNVYIFPG LGLGAILAKA SRVTDEMVYT SAAALAGSLN ADEVHKGLIY PRIERVRDAS
VIVAREVMKA ARRGGVSELP ESQWAEWEEW GDVALTTYIK QRIYNPLCFA DAKTHL
//
