ID A0A0J9Y630_BRUMA Unreviewed; 1056 AA.
AC A0A0J9Y630;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=BMA-SMG-2 {ECO:0000313|EMBL:CDQ02457.2, ECO:0000313|WBParaSite:Bm6673.1};
GN Name=bma-smg-2 {ECO:0000313|WormBase:Bm6673};
GN Synonyms=Bma-smg-2 {ECO:0000313|EMBL:CDQ02457.2};
GN ORFNames=Bm6673 {ECO:0000313|WormBase:Bm6673}, BM_Bm6673
GN {ECO:0000313|EMBL:CDQ02457.2};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CDQ02457.2};
RN [1] {ECO:0000313|EMBL:CDQ02457.2, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ02457.2,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDQ02457.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ02457.2};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm6673.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2022) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
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DR EMBL; LN857024; CDQ02457.2; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J9Y630; -.
DR EnsemblMetazoa; Bm6673.1; Bm6673.1; WBGene00226934.
DR WBParaSite; Bm6673.1; Bm6673.1; WBGene00226934.
DR WormBase; Bm6673; BM38350; WBGene00226934; Bma-smg-2.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR CDD; cd21407; 1B_UPF1-like; 1.
DR CDD; cd18039; DEXXQc_UPF1; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR CDD; cd21400; ZBD_UPF1-like; 1.
DR Gene3D; 2.40.30.230; -; 1.
DR Gene3D; 6.10.140.1240; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR040812; UPF1_1B_dom.
DR InterPro; IPR018999; UPF1_CH/ZBD.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF18141; UPF1_1B_dom; 1.
DR Pfam; PF09416; UPF1_Zn_bind; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51997; UPF1_CH_RICH; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT DOMAIN 77..234
FT /note="Upf1"
FT /evidence="ECO:0000259|PROSITE:PS51997"
FT REGION 85..117
FT /note="C3H"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 99..127
FT /note="CC/SHH/C"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 145..175
FT /note="C4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
SQ SEQUENCE 1056 AA; 118422 MW; D236EF7C29E5508E CRC64;
MVDSLEDEYG TPSLSLNFVD TPDGDSSLLH GATQDSQFEF DQQFTLPSQG WTSTLPEVGG
DQSQELVFVD EEEFSVPGQL PTHACRYCGI HDPATVAMCM VCEKWFCNGR GSTSAGHIVI
HLVRSQHKEV SLHKEGALGE TVLECYQCGS KNIFMLGYIP AKADTVVVVL CRSPCANQAV
LKDHSWQVDE WKPLISDRQL LSWLVKIPSE QEQLRARQIS AVQINRLEEL WKEDPKAVFE
DLERPGMDEE PEHVQLKYED AYQYKRVFEP LVKAEADYDR REKESQTQSV GHVRWDIGLN
RKPQAFFQLP KFSEGSMKLM LGDELRLKHS QTAGGEWSSV GCVIKIPDNH NDEVGIEMRL
KAENVPTDTR TNFTCEFVWN STSFERMQAA LSLLGQDEDC VSQFIYHKLM GHDIDDIIFK
VSLPKRFSVP GLPELNHSQV HAVKTVLQRP LSLIQGPPGT GKTVTSATIV YHLVKQTNGQ
VLVCAPSNIA VDQLAEKIHR TGLKVVRLCA KSRETLDSPV AFLALHNQLR ALHGAAELHK
LQQLKEEMGE LADADERRFR ALRIAKECQL LTAADVICCT CVSAADSRLS HMRIKCVLID
ESTQATEPEV MVAVVCGVRQ LVLVGDHCQL GPVIMCKKAA KAGLSQSLFE RLVLLGNRPI
RLQVQYRMHP ALSSFPSNVF YEGSLQNGVT EGERQLIGID WQWPVPDKPM MFWSCYGQEE
LSSSGTSFLN RTEAANVEKL ATRFLKAGLK PEQIGIITPY EGQRSYIVQF MQTQGALHSK
LYLEMEVANV DAFQGREKDI IIVTCVRSND HQGIGFLNDS RRLNVALTRA KFGLIIVGNA
KVLSRHPLWN YLLSMFKEKG CLVEGPLNNL KPSPITLSKP RRIPNIMSMN RFIPRGVVLA
KDMQGNAFGT RNRDLRSIQD PFAAITHGQL RPQNGINIPV PIQMFVQPPP HYYPLHTRHG
DLNSVDSTTR NRKHLEGINM FSSQQSQDPI YMQQLGEMSG ISQDVSDWTQ SQTQHGASQG
GVPYSQDQLL VSQMESLFLS QDANAENYNF GDVSQY
//