ID   A0A0K0DTT4_STRER        Unreviewed;       970 AA.
AC   A0A0K0DTT4;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE            EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
OS   Strongyloides stercoralis (Threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=6248 {ECO:0000313|WBParaSite:SSTP_0000064700.1};
RN   [1] {ECO:0000313|WBParaSite:SSTP_0000064700.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (AUG-2015) to UniProtKB.
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DR   AlphaFoldDB; A0A0K0DTT4; -.
DR   STRING; 6248.A0A0K0DTT4; -.
DR   WBParaSite; SSTP_0000064700.1; SSTP_0000064700.1; SSTP_0000064700.
DR   Proteomes; UP000035681; Unassembled WGS sequence.
DR   GO; GO:0042575; C:DNA polymerase complex; IEA:UniProt.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd00303; retropepsin_like; 1.
DR   CDD; cd01647; RT_LTR; 1.
DR   Gene3D; 3.30.70.270; -; 2.
DR   Gene3D; 2.40.70.10; Acid Proteases; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR001995; Peptidase_A2_cat.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR041373; RT_RNaseH.
DR   PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR   Pfam; PF17917; RT_RNaseH; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50175; ASP_PROT_RETROV; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035681};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          34..114
FT                   /note="Peptidase A2"
FT                   /evidence="ECO:0000259|PROSITE:PS50175"
FT   DOMAIN          671..858
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
FT   REGION          921..959
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   970 AA;  112012 MW;  F3971FA16807A427 CRC64;
     MFIFEENLFP SEKDNENKTN SQAIVSYMKK IIHVTALLDT GASITCISHD LAKNLNLIAT
     SETTVKSFQK RISKVPKYES DTNLLFIEYQ HHIISLKKVI IADNDHEIIL GRDAKAQIDQ
     SIEDENKCKE MVRKNFPNNI SRDRFDLGQC SIKAPPIIFK SLEMESFKRY DLPKDVENKM
     MHDVNKLIEM NIIEPGIADY ILNSLGKTYC SAKPSYFLQH LNQFTHISSI DLTQAYMQIL
     ISDQDFNKVG FHLGSRLYIV KRLMFGMHSS PGIWQSIIDE ILKNTIAISY QDDIIVATTG
     TIEHHLHELH NTMVALSQNN LKINLDKSSF GRKSINYLGF HITPRGISIQ QKFIDFLNNI
     KQPQSIHDLR SFRGIVGFLR NHIEGLAPLE DEMNTFIGGT SKQNGKHKIS IPSSVLSKIE
     VIKDKIRHAP LLHHIDLKLP FLIFCDASEF GFGSLLAQPC KPLTDYTTVQ QDQVVPIAFH
     SRSIRNHRRL IPAVLLELMC IADCLVNFKE LLYNRCLYIF TDHRNLQKII KESTDPRYRK
     YIFTILTFTP EDIIFIPGHK NTIPDYLSRC GSPSPSPIQE EEENLIIEEK NDNKENIANK
     LFIQVYIKNN HLSLKKIFFR VKEYLIKNIK KEKKIRQIMA ILRKKLNDCE VCRLNNDTRR
     KKINKNNERF LNLEPFQEIS LDCTFINNNT IVVAIDHASG YVIAKIIPDQ SINSIKSFLQ
     QRIFYIFGLP NRIHLDNFKT FTSKKFLKEM EDFNTRITFA DPDSHSTNPL VERMNRTIKL
     AVRKTENWRK KFEQIIFNIN HSEYEDLNIS PHDVVFAYKV KKFNANIEES NRQLFAGELK
     QIANIIRHLP KEIIMKNRKQ YPNSSSNRNK LVKINEESLD TDTITRSLQT HTVFCFPWSN
     SFFIKKKEVF NTFYNNKNLN ESQPNQSTPL LPCAPIADTA DAPPAAAPAP TSSLPPTGFQ
     LFIPKRGGFN
//