ID   A0A0K0E4P9_STRER        Unreviewed;       380 AA.
AC   A0A0K0E4P9;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Hcy-binding domain-containing protein {ECO:0000313|WBParaSite:SSTP_0000446800.1};
OS   Strongyloides stercoralis (Threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=6248 {ECO:0000313|WBParaSite:SSTP_0000446800.1};
RN   [1] {ECO:0000313|WBParaSite:SSTP_0000446800.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (AUG-2015) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PROSITE-ProRule:PRU00333};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo
CC       pathway. {ECO:0000256|ARBA:ARBA00034478}.
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DR   AlphaFoldDB; A0A0K0E4P9; -.
DR   STRING; 6248.A0A0K0E4P9; -.
DR   WBParaSite; SSTP_0000446800.1; SSTP_0000446800.1; SSTP_0000446800.
DR   Proteomes; UP000035681; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.330; Homocysteine-binding-like domain; 1.
DR   InterPro; IPR003726; HCY_dom.
DR   InterPro; IPR036589; HCY_dom_sf.
DR   PANTHER; PTHR46015:SF1; ZGC:171603 PROTEIN; 1.
DR   PANTHER; PTHR46015; ZGC:172121; 1.
DR   Pfam; PF02574; S-methyl_trans; 1.
DR   SUPFAM; SSF82282; Homocysteine S-methyltransferase; 1.
DR   PROSITE; PS50970; HCY; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00333};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW   ProRule:PRU00333}; Reference proteome {ECO:0000313|Proteomes:UP000035681};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW   ProRule:PRU00333}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00333}.
FT   DOMAIN          1..322
FT                   /note="Hcy-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50970"
FT   BINDING         238
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00333"
FT   BINDING         307
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00333"
FT   BINDING         308
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00333"
SQ   SEQUENCE   380 AA;  44191 MW;  731DCB84D605896C CRC64;
     MEYQILDGGL GTTIQKFYNT EDDRKKYIDH GFFSFNLAVD KQWLQLANIH MQFLKNYSTT
     LYTSHYQASI PRLFKKLKNL NEIWHLLKIS YEIPKCIMQF YGNHIRNTSS LPNVIISCGS
     MATFFSNKTE YLNRKSHPLY KNEIFLKDIV EMYYKIQVQS LLSLSPECII FETLSLYDET
     ESLINVLNTL STHNLPNMCF GLSITCKNDE ETFGDCKIVD IFTLVKKSNK FKYFGINCTH
     PKYISNILRN LKSLNNEDNY LEIIIKSNKG DIIYENGLPR SVDGAKLFYE YVDEWVTIMP
     IIGIGGCCGV LPEDIGELYK RKNQCVTIIE NQSMIKNEDL KFLIEKVIDD SEEFSTNKHL
     GIETSDLEKF FELANNYNLQ
//