ID   A0A0K0EAY5_STRER        Unreviewed;      1255 AA.
AC   A0A0K0EAY5;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Endonuclease {ECO:0000313|WBParaSite:SSTP_0000665900.1};
OS   Strongyloides stercoralis (Threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=6248 {ECO:0000313|WBParaSite:SSTP_0000665900.1};
RN   [1] {ECO:0000313|WBParaSite:SSTP_0000665900.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (AUG-2015) to UniProtKB.
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DR   AlphaFoldDB; A0A0K0EAY5; -.
DR   STRING; 6248.A0A0K0EAY5; -.
DR   WBParaSite; SSTP_0000665900.1; SSTP_0000665900.1; SSTP_0000665900.
DR   Proteomes; UP000035681; Unassembled WGS sequence.
DR   GO; GO:0042575; C:DNA polymerase complex; IEA:UniProt.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR   CDD; cd01647; RT_LTR; 1.
DR   Gene3D; 1.10.340.70; -; 1.
DR   Gene3D; 3.30.70.270; -; 2.
DR   Gene3D; 2.40.70.10; Acid Proteases; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR041588; Integrase_H2C2.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR041577; RT_RNaseH_2.
DR   InterPro; IPR001878; Znf_CCHC.
DR   PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR   Pfam; PF17921; Integrase_H2C2; 1.
DR   Pfam; PF17919; RT_RNaseH_2; 1.
DR   Pfam; PF00665; rve; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
DR   PROSITE; PS50878; RT_POL; 1.
DR   PROSITE; PS50158; ZF_CCHC; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035681};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT   DOMAIN          214..229
FT                   /note="CCHC-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50158"
FT   DOMAIN          444..622
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   DOMAIN          992..1149
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
FT   REGION          1215..1255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1236..1255
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1255 AA;  142988 MW;  215A9B6B49DDAE38 CRC64;
     MGERGGSIVQ GVGEFCPAKE KVEDWLERLD VALDMGCISE ARLRRLILIR DLGAKAFSEV
     KAKLAPRLLK DVEEKEIRKI MVEIYSNEKT SPTVSLLELL NMRQGEESLR EFGLLIRRSA
     RECSLEEWGK GKEQFLSLIF LNGLKDEIVK RVLMASKELN LDKLIEIGRS HEIVHQKGTV
     VAYVKNERKS QFKCMCCGRN GHTKERCRLK DRECHGCGRK GHLKNMCKNG NKKGTMGNVD
     VEYDSESEEE MYHLDEISTG KNKNLSGLVR VSIMDQNIMF KLDTGADKSI ISKNVWEQLG
     KPALVTKNIN ENLFDVNGQK LEILGYLRCK ISIKNVEYPA ELRVFERNKC LIGKDLIMAV
     KLDLNSLFYE MDDITKGEGF SASDQTQVFI QKYPRLFDTQ RNDGSKLTAK LILKKDHIPK
     FVPPRRHPYA LRDKVNEELR RMIAMNVIKP VPTSKWSSPI CAVLKPDGSV RICGDYSKTV
     NPQLDIEQFP IPSLYEALDK VSNCSIYGKI DLKNAFNQLH MDKEGAEILS LSTPLGLMSV
     LRLQPGVASA PAIFQNAMYS RLSLVSNCSC YFDDIIVGSD SKLNLVKKLD EVLGILDNMG
     LVVNPKELEL FKSEVLFLGH IISSQGRRPS PEKIQGILCL KTPKNAAEVH TFIGKCLHYA
     DYIKNASLKA RPLYNLIRKG TKFIWSEVEN KAFLELKKDL ETITTLTLFD EKKIVVLACD
     ASEFGLGSVL LLRDPVTKKE RPFAHASRTF SGSQRNWSQL DKEAAGIIFG VTKFQDFLLG
     RQFVLQTDSK PLTYLFGDKA GLPITALKRV DRWSIILQRF TYSIEYVKTG EFSKVDCLSR
     LPSSEILPDD VEVLEVEDAM LNNVPLDLGR IREAQSNDKI ISIVSQLVLT TFPEYIKDAE
     IKEFKKYQFE LSVIKGVLFR NNCVVIPEKL KNEVLKLLHQ GHFGSSKIKM LARSYVFWPG
     YTNDIEVMVK GCRTCQEFGD PKTNEGLHSW EKAPSPWFRI HMDFAGPFMG SMWLLIVCAM
     SKFPHVYRMS KTESVNIIYC LKELFALHGN PVQLVTDNGR NFTSREMSRF LASRKIVHIR
     TPAFHPMSNG QCERFVKTFK QSMNKLTESY SIEESVQIFL QQFRITPNKF NKISPSEAMF
     RRQIRTTLNC LLEEPADDIV NKKFTVLYDQ GEEVYTRNYK ASSKKVWEPA IIDSQHAPNL
     YFVKTETVPK KLVHTSQLKS SGEPAKGLKK WDQPGLSFSR SYNSRVTRNP QPKYK
//