ID   A0A0K0EBS5_STRER        Unreviewed;       444 AA.
AC   A0A0K0EBS5;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Purple acid phosphatase {ECO:0000256|RuleBase:RU361203};
DE            EC=3.1.3.2 {ECO:0000256|RuleBase:RU361203};
OS   Strongyloides stercoralis (Threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=6248 {ECO:0000313|WBParaSite:SSTP_0000694600.1};
RN   [1] {ECO:0000313|WBParaSite:SSTP_0000694600.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (AUG-2015) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a phosphate monoester + H2O = an alcohol + phosphate;
CC         Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2;
CC         Evidence={ECO:0000256|RuleBase:RU361203};
CC   -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily. Purple
CC       acid phosphatase family. {ECO:0000256|RuleBase:RU361203}.
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DR   AlphaFoldDB; A0A0K0EBS5; -.
DR   STRING; 6248.A0A0K0EBS5; -.
DR   WBParaSite; SSTP_0000694600.1; SSTP_0000694600.1; SSTP_0000694600.
DR   Proteomes; UP000035681; Unassembled WGS sequence.
DR   GO; GO:0003993; F:acid phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   CDD; cd00839; MPP_PAPs; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR041792; MPP_PAP.
DR   InterPro; IPR008963; Purple_acid_Pase-like_N.
DR   InterPro; IPR025733; Purple_acid_PPase_C_dom.
DR   PANTHER; PTHR45867:SF3; ACID PHOSPHATASE TYPE 7; 1.
DR   PANTHER; PTHR45867; PURPLE ACID PHOSPHATASE; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   Pfam; PF14008; Metallophos_C; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR   SUPFAM; SSF49363; Purple acid phosphatase, N-terminal domain; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hydrolase {ECO:0000256|RuleBase:RU361203};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035681};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU361203}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|RuleBase:RU361203"
FT   CHAIN           22..444
FT                   /note="Purple acid phosphatase"
FT                   /evidence="ECO:0000256|RuleBase:RU361203"
FT                   /id="PRO_5009733221"
FT   DOMAIN          100..300
FT                   /note="Calcineurin-like phosphoesterase"
FT                   /evidence="ECO:0000259|Pfam:PF00149"
FT   DOMAIN          324..387
FT                   /note="Iron/zinc purple acid phosphatase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14008"
SQ   SEQUENCE   444 AA;  52290 MW;  5D846184030F79F2 CRC64;
     MIFIITIQLN IFFLLNLIIN GLEESLEHEQ VHLSLGKDPR TMVVSWLNME EKGIPFSYKV
     MYYYKVGDGK RWSKTFYFKT FPKTSRFKLK FCTFGDSDTG KMFTINELKK SVKRGECQMI
     IHLGDIAYQL QRDNGFTGDD FMRKIEPIAA YVPYMVIVGN HEFDCHGFTH YNYRFAMPYD
     KNNADDVDHF YSFNIGLVNF IGLSSEIYGF YKLYGINPIK KQTKWFDKTL KSIEKYKKIR
     PWTITFFHRP IYCWHRFIPD ECNEYESSTL RVGHKKIPGL ERYLHKYNVD VVLNAHEHGY
     QRNYPIFNRT VYKYKNNIYH NSPATTYILS GAGGCNRCTP AIFNNSGSLP FAAKRTISVG
     YTQINVINKT HMKINQIDTE NKAIVDSFWI VKDLGFKMSR SKKSRRVKGK YAPYNGDQIY
     QYLEPSRLIK KCIQLYNISM YNEK
//