ID A0A0K0ESU4_STRER Unreviewed; 1390 AA.
AC A0A0K0ESU4;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Rap guanine nucleotide exchange factor 2 {ECO:0000313|WBParaSite:SSTP_0001252300.1};
OS Strongyloides stercoralis (Threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=6248 {ECO:0000313|WBParaSite:SSTP_0001252300.1};
RN [1] {ECO:0000313|WBParaSite:SSTP_0001252300.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (AUG-2015) to UniProtKB.
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DR AlphaFoldDB; A0A0K0ESU4; -.
DR STRING; 6248.A0A0K0ESU4; -.
DR WBParaSite; SSTP_0001252300.1; SSTP_0001252300.1; SSTP_0001252300.
DR Proteomes; UP000035681; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01785; RA_PDZ-GEF1; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF249; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 2; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000035681}.
FT DOMAIN 36..83
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 397..497
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 527..645
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 646..717
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 857..942
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 967..1194
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1231..1272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1305..1352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1368..1390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1234..1272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1390 AA; 158179 MW; AA63BE0871BF3772 CRC64;
MYKFTPDFKN ALIKNPKERA KNDIDIIFSH LKQLEGFKWI NDTALRKISR AARYEAYPMN
HILFRKGQPA TCWYILLTGS VYIDEQIQLP LGCFGKRNEV HLRRISDCII LQPSELIVID
YPDDQRVPIY QTIQENTNNV YKLQNNFQTN LQIKGTQFGD QLDAPYYDNN QVQSSTLRSK
QIPLYEMTSE KKNLFNGIDN VDCSVNPTPT IGISRITVQS SQTNKFTVHN KQIPKVYNNL
PDILNCPPIP PKTPNLHLKN DISALDSPTI PYHHIFKNQL QPYVRYRTHN SQLQRKSLDE
TAMQANSEKN IKNIINTSVK QPTFITVGGS SNSLKNDELS GLPEAFVDSD DEEGSCPSHD
SFQELRDNVR ECLEKEPSMR TLDDILILLD FMSQMQAFAN LPMSIRKQIC LKMLFAVVQD
SGTVILQHGD KLDSWSVVVN GYVEWTKPNG EKIEYRMGDA FGATASPTEQ YHEGEMKTMT
NNCEFLLVEH KDFYHIMSTI NQHIEKISDV TGEVVSETER RVTGNQVGLV IIKAKPEKLL
QLLVEESDTI SDEHYTEDYL LMYRVFLPDP TEIFLKLKQW FEDPIFKEKI PRIVLLWVNS
HFNDFESNNK MIKLLEEFGD SLEQENLHSQ LALLNIACSI KSKIRTVILT RSNRDQELCF
TLIGGKEINH KLFVADISNN CDSQTIGLRR GDEILEVNGH NFSSITLSKA LVLLKDSTHL
SIHVKWNLMG FKEMLIDMES RKNTYDYDSI SSNETSFTSI RYGKNDGSGI YLPSRQYNSS
SSSVNTKLSN ISSKNSMMSK LINIIKGSNS GSDSGFSNDL QNTSNIMNTS VINSSLPPLS
DPFDNTKLAT ANQIEEVIKV YRSDQTFRYL VIYPTTTVSD IVKLALQEFG MNTDTGHLEW
TLCMTSVTPE GAIKQRTLPQ SMTNMGSYLN LNSRYYLKNN DRSEPLLPDD VAPEVLKESQ
IYLIDLNAHT IAVHLTLQDF GIFSKIETTE YVDCLFEIKS SYGWPMLKKF EDIFNIEMWW
VATEICSEKI VYKRAKLIKK FIKVARHCRE LRNFNSMFAI ISGLEKPAVR RLQNSWERVP
NKYIKMLNDM QTLLDPSRNM SKYRQHLLNL SQDPPVIPIY PVFKKDLIYS NEANETYSDK
LINFEKLRII AKIIRSVTKL SLVPYTQEVI LNRDSLNIDS KSSTSTIKKL SGVKNGSQSR
KKMYEQDQMV KKVKSYLEVM KICDNENELD KMSSECEAPQ NSSSGNASSG TSRRRAPSPS
SSSISSHSNQ SEQFARFNTP KFGVESPQAV QKMLSLVQNS KIKPANNVKG FSPMQSPMLN
NNRGTPKRSN AGIGRIPSFS SRSSSNSTDL HPVDLTAESS SVTTFCSNSL QNTNSTDIGP
GAFIRPVRRK
//
