ID A0A0K0J4I4_BRUMA Unreviewed; 375 AA.
AC A0A0K0J4I4;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=BMA-TSG-101 {ECO:0000313|EMBL:CRZ25060.1};
DE SubName: Full=Tumor susceptibility gene 101 protein {ECO:0000313|WBParaSite:Bm2116.1};
GN Name=bma-tsg-101 {ECO:0000313|WormBase:Bm2116};
GN Synonyms=Bma-tsg-101 {ECO:0000313|EMBL:CRZ25060.1,
GN ECO:0000313|WBParaSite:Bm2116.1};
GN ORFNames=Bm2116 {ECO:0000313|WormBase:Bm2116}, BM_Bm2116
GN {ECO:0000313|EMBL:CRZ25060.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|Proteomes:UP000006672, ECO:0000313|WBParaSite:Bm2116.1};
RN [1] {ECO:0000313|EMBL:CRZ25060.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ25060.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CRZ25060.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ25060.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm2116.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UEV
CC subfamily. {ECO:0000256|ARBA:ARBA00009594}.
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DR EMBL; LN856996; CRZ25060.1; -; Genomic_DNA.
DR RefSeq; XP_001893236.1; XM_001893201.1.
DR STRING; 6279.A0A0K0J4I4; -.
DR EnsemblMetazoa; Bm2116.1; Bm2116.1; WBGene00222377.
DR GeneID; 6096692; -.
DR KEGG; bmy:BM_BM2116; -.
DR WBParaSite; Bm2116.1; Bm2116.1; WBGene00222377.
DR CTD; 6096692; -.
DR WormBase; Bm2116; BM01439; WBGene00222377; Bma-tsg-101.
DR OMA; GTVYKFP; -.
DR OrthoDB; 37962at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0000813; C:ESCRT I complex; IEA:EnsemblMetazoa.
DR GO; GO:0032510; P:endosome to lysosome transport via multivesicular body sorting pathway; IEA:EnsemblMetazoa.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0032801; P:receptor catabolic process; IEA:EnsemblMetazoa.
DR Gene3D; 6.10.140.820; -; 1.
DR Gene3D; 6.10.250.370; -; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR017916; SB_dom.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR008883; UEV_N.
DR PANTHER; PTHR23306:SF3; TUMOR SUPPRESSOR PROTEIN 101; 1.
DR PANTHER; PTHR23306; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED; 1.
DR Pfam; PF05743; UEV; 1.
DR Pfam; PF09454; Vps23_core; 1.
DR SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS51312; SB; 1.
DR PROSITE; PS51322; UEV; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 6..149
FT /note="UEV"
FT /evidence="ECO:0000259|PROSITE:PS51322"
FT DOMAIN 309..375
FT /note="SB"
FT /evidence="ECO:0000259|PROSITE:PS51312"
SQ SEQUENCE 375 AA; 41917 MW; BF03D6089C0DFD05 CRC64;
MTNNAVSSTV TALLNRAKAK YVDTAKIDIL SALSGFPDLT PNVEDFIYPD KTCTLAFCLK
GTIPVFYKGK TYNIPVALYL WDTHPYYAPI CYVCPTPNMV LKESKTVDDL GRISLPYLSD
WTFPGYDLSG LLQVMAMCFQ DSCPVFARPG SNSHVSAVGS VWDRSAGQIQ SYIPYPVSNT
SGVPPYPTSF TSYYPLMPSF NDNVSSGTVQ PEHLKASVMS AVEHKIRQRL REKLGTMHAE
LASIRQTHAD LRAGQQKLKV ILDDLAQEQK RMEGALIVYQ EKKAEISSVL STSSPEKTVE
IDQVIDACTP LHKQLLCCYV YDCAIDDAIY FLGQALSRGR ISLTNYLKEV RQLSRRQFIY
RATLQKCRIK AKMPV
//
