ID A0A0K0J5Z0_BRUMA Unreviewed; 1861 AA.
AC A0A0K0J5Z0; A0A0H5SBM7;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 2.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=BMA-NCA-2 {ECO:0000313|EMBL:CRZ25505.1, ECO:0000313|WBParaSite:Bm2434.1};
GN Name=bma-unc-77 {ECO:0000313|WormBase:Bm2434};
GN Synonyms=Bma-nca-2 {ECO:0000313|EMBL:CRZ25505.1};
GN ORFNames=Bm2434 {ECO:0000313|WormBase:Bm2434}, BM_Bm2434
GN {ECO:0000313|EMBL:CRZ25505.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CRZ25505.1};
RN [1] {ECO:0000313|EMBL:CRZ25505.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ25505.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CRZ25505.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ25505.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm2434.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2022) to UniProtKB.
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DR EMBL; LN857010; CRZ25505.1; -; Genomic_DNA.
DR EnsemblMetazoa; Bm2434.1; Bm2434.1; WBGene00222695.
DR WBParaSite; Bm2434.1; Bm2434.1; WBGene00222695.
DR WormBase; Bm2434; BM34514; WBGene00222695; Bma-unc-77.
DR OMA; TLFIAWN; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028823; NALCN.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46141:SF1; SODIUM LEAK CHANNEL NALCN; 1.
DR PANTHER; PTHR46141; SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 105..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 548..570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 617..641
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 912..935
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 989..1008
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1053..1075
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1167..1193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1248..1268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1280..1300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1320..1340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1352..1370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1391..1414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1475..1502
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 82..372
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 426..648
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 918..1197
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1246..1512
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
SQ SEQUENCE 1861 AA; 215733 MW; 2B252FF9087C4008 CRC64;
MTGVMLTCRK SSIVIQQQQQ QQQQQLQQQQ QVQQQQISIG TERGANDSVA VLSEMLNMDS
SASKQHTSDI LRSSIFEDIP KLACLISMMS VCLNTPHTFS FFPPLYYIVF LADAIVTIVF
LIEAIVKIVT NGLITYEGSY LRDRWCQFDF FLLTLHITSV LLNAYELICL WFPHLKWHYH
PWYGVIRAPR PFIMIRFVRS IVRFKLPKNR IQQIIKRSSQ QIQNVTIFFM FFMTFYAIMG
VQLFGRMDYH CVLPGTNISN VTIADLAIPD TMCSQKGAGG YECPTNMECL KLDMSAHAEG
FYGMFNDFGS SLFTVYMAAS QEGWVYVLYD CLDTFPSYIA FFYFITLIFL LAWLVKNVFI
AVITETFAEI RVQFSEMWQT REITIEDSFA QKLEKTEDGW RLMAVDAEKI NPDSAPKPLY
WLVRSAVFQT CMMVMVVLNA VINASFVYKH DASDEPRKLF YYYIEVGFTI IFNVECLLKM
VALGWNGYIR LHKFELILCI GSTLNIVKPL YSMNLFTYFQ VFRIVRLIRA SPMLEDFVYK
IFGPGKKLGG LVVFTMVLLV ITSAVSLQLF CYVPNLDKFR TFPQAFMSMF QIITQEGWTD
VVVEILRTTN ESMVPFVAIY FVGYHLFVTL IVLSLFVAVI LDNLEMDEEL KKVKQLKARE
ETTCMRTTLP WRLKIFEKFP TRPQMVELRK VSGEFPLPKV RQSFTKQFAE DNTLTYSFHS
EESDLQRKQL LRSVGRSFFR SSVTVRQIGQ LSSKWTISIL IEEANRNRAL FLDSNQFIAQ
LGQGGTRIWG DSRYHNRSIN RPVKLKVVYE HLKENGDVRL ADSAPKNDLK HGEIDIKALQ
QKRQHAELTR NRIEEEIREN HPFFDRPLFL VDRDSRLRHI CHEIVYAKYM PDKIDSITGK
QIQQRYKQLH ELIGLLTYLD WAMVFFTALS CYSMLFESPW PTTGENLIFN NPYLQICEYM
FVISMTFELA VKVLANGFIF TPNAVVRDVG GVMTLFIYIT SVIYLIWMPR YVEINSLAQM
MMIFRAMRPL RIYTLVPHIR RVVVELCKGF KEILLVTTLL ILLMFIFASF GVQIAGGKLA
ACNDPAITER EKCFGIFEQK VFVTRMEVYG KNDNELHPKI WVPRVWTNPR NFNFDHIGNA
MLALFETLSY KGWNVIRDIL WMRQGPWAVV FIHIYVFTGC MIGLTLFVGV VIANYTENRG
TALLTVDQRR WHDLKARLKM AQPLHVPPKP AESAKLRIRL YEMTLSRWFK QVFAVLVVIN
SVTLFIPWNV EEEKNSYKAL VFMTGVSAIA NILFTFEILL KMIAFTVRGF WQSRRNRIDL
LITVLGLFWI FTHFIMALPA SAVGGPTELK EFTYTFGYLV VILRFFTIAG RKTTLKMLML
TVVMSMVRSM FIITAMFLLV LFYAYTGVIL FGMVKYGQAV SKHVNFRNAK EALVVLFRSV
TGEDWNDIMH DCMRSPPLCY WKKGVSYWQT DCGNYFGAII YFCSFYLIIT YIVLNLLVAV
IIENFSLFYS SEEDALLSYA DIRNFQQVWN IVDVEQKRTI PVRRVKFLLR LLKGRLEVDP
NRDRLLFKYM CHEMVRLHNG DDISFHDVLN MLSYRSVDIR KSLQLEELLH REELEYIIEE
EVAKQTIRSW LEGSLRRIKA QQNKDNSLIA HLRPFLNEQH SMHSMLQLNQ MNAASNLQQD
QPQQLGELLD NEEEELIKCK STKRSRRSSI PELVGEAAKK FIFTGSSSAR VRGVHSAQSV
DRTSFREEKS VKSLLSTEKS IAVTRDEKRS IKGVQVNLPA SELPDVEEWN EENVSSDVAN
FADRRYSAES ALLAVNEFSN DAISFTGKLT NTPFTWASSS VVEENAHVRE WWSKFNVLIL
S
//
