ID A0A0K1K4K4_9BURK Unreviewed; 427 AA.
AC A0A0K1K4K4;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Multidrug transporter {ECO:0000313|EMBL:AKU24299.1};
GN ORFNames=ACZ75_25405 {ECO:0000313|EMBL:AKU24299.1};
OS Massilia sp. NR 4-1.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Telluria group; Massilia.
OX NCBI_TaxID=1678028 {ECO:0000313|EMBL:AKU24299.1, ECO:0000313|Proteomes:UP000056897};
RN [1] {ECO:0000313|EMBL:AKU24299.1, ECO:0000313|Proteomes:UP000056897}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NR 4-1 {ECO:0000313|EMBL:AKU24299.1,
RC ECO:0000313|Proteomes:UP000056897};
RA Sul W.J.;
RT "Massilia sp. NR 4-1 isolated from rhizosphere of Torreya nucifera in
RT national heritage Bijarim forest, volcanic Jeju Island, Korea.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004519}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004519}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; CP012201; AKU24299.1; -; Genomic_DNA.
DR RefSeq; WP_050411983.1; NZ_CP012201.1.
DR AlphaFoldDB; A0A0K1K4K4; -.
DR STRING; 1678028.ACZ75_25405; -.
DR KEGG; mnr:ACZ75_25405; -.
DR PATRIC; fig|1678028.3.peg.5155; -.
DR OrthoDB; 9783047at2; -.
DR Proteomes; UP000056897; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF3; MULTIDRUG EFFLUX PUMP SUBUNIT ACRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000056897};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..427
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005462106"
FT DOMAIN 37..360
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 59..293
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 369..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 427 AA; 43551 MW; 400C103A94D34423 CRC64;
MRSVPRYTPL AAAIVSLTLL AACGDKKNAS NAPPPPPTVS VITVAAASVA ISDELPGRVE
ASRIAQVRAR TPGIVLQRVF KEGGDVKAGE TLFRIDPAQT QATFDSAGAA VAKAEANLAQ
AELKVKRYKP LLAAQAVSQQ EYDDALTAQK QASADLATAR ATRQTASLNL GYTTVTAPIS
GRVGRALVTE GALVGQGEAT PLAVVQQLDP IYVTVTQSST ELLRLKQALA DGKLKSAGKD
QARVTLVTED GREYPQAGKL LFSDVAVDES SGSVSMRAEF PNPSRNLLPG MYVRAHLEQG
VNEAAITVPQ QAVVRGAEGA TVMIVGADNK VTAQPVKADA AQDNRWIINS GLKGGERIIV
EGFQKAKPGG TVNPVPWQAP AAGKGGTPAN GAAPGAAQAN GGAPGAAASA PATPAKAAAS
APAASAK
//
