ID A0A0K1W0B3_9MOLU Unreviewed; 867 AA.
AC A0A0K1W0B3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Aldehyde-alcohol dehydrogenase {ECO:0000256|PIRNR:PIRNR000111};
GN Name=adhE {ECO:0000313|EMBL:AKX33750.1};
GN ORFNames=SLITO_v1c00820 {ECO:0000313|EMBL:AKX33750.1};
OS Spiroplasma litorale.
OC Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales; Spiroplasmataceae;
OC Spiroplasma.
OX NCBI_TaxID=216942 {ECO:0000313|EMBL:AKX33750.1, ECO:0000313|Proteomes:UP000067476};
RN [1] {ECO:0000313|EMBL:AKX33750.1, ECO:0000313|Proteomes:UP000067476}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TN-1 {ECO:0000313|EMBL:AKX33750.1,
RC ECO:0000313|Proteomes:UP000067476};
RX PubMed=26430038;
RA Lo W.S., Lai Y.C., Lien Y.W., Wang T.H., Kuo C.H.;
RT "Complete Genome Sequence of Spiroplasma litorale TN-1T (DSM 21781), a
RT Bacterium Isolated from a Green-Eyed Horsefly (Tabanus nigrovittatus).";
RL Genome Announc. 3:e01116-15(2015).
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- SIMILARITY: In the C-terminal section; belongs to the iron-containing
CC alcohol dehydrogenase family. {ECO:0000256|ARBA:ARBA00035645,
CC ECO:0000256|PIRNR:PIRNR000111}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the aldehyde
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00035641,
CC ECO:0000256|PIRNR:PIRNR000111}.
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DR EMBL; CP012357; AKX33750.1; -; Genomic_DNA.
DR RefSeq; WP_075057849.1; NZ_CP012357.1.
DR AlphaFoldDB; A0A0K1W0B3; -.
DR STRING; 216942.SLITO_v1c00820; -.
DR KEGG; sll:SLITO_v1c00820; -.
DR PATRIC; fig|216942.3.peg.82; -.
DR OrthoDB; 9804734at2; -.
DR Proteomes; UP000067476; Chromosome.
DR GO; GO:0008774; F:acetaldehyde dehydrogenase (acetylating) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006066; P:alcohol metabolic process; IEA:InterPro.
DR GO; GO:0015976; P:carbon utilization; IEA:InterPro.
DR CDD; cd08178; AAD_C; 1.
DR CDD; cd07122; ALDH_F20_ACDH; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR034789; AAD_C.
DR InterPro; IPR001670; ADH_Fe/GldA.
DR InterPro; IPR018211; ADH_Fe_CS.
DR InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR012079; Bifunc_Ald-ADH.
DR PANTHER; PTHR11496; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR11496:SF83; HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF00171; Aldedh; 1.
DR Pfam; PF00465; Fe-ADH; 1.
DR PIRSF; PIRSF000111; ALDH_ADH; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
DR PROSITE; PS00060; ADH_IRON_2; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR000111};
KW Reference proteome {ECO:0000313|Proteomes:UP000067476}.
FT DOMAIN 3..266
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT DOMAIN 452..849
FT /note="Alcohol dehydrogenase iron-type/glycerol
FT dehydrogenase GldA"
FT /evidence="ECO:0000259|Pfam:PF00465"
SQ SEQUENCE 867 AA; 95883 MW; 9FF8A1B5CEDBFB38 CRC64;
MKEFEDLFKK ARESFEEFSQ FTQEKVDYIF KKAALAANEN RIHLAKLAKE ETKMGIIEDK
ILKNHYASEF IYNKYKDLKT VGTFYSNDPG GIDKVYEPIG VVGAVIPTTN PTSTAIFKCL
LCIKTRNTII ISPHPGAKKS TIEAAKIVLE AAVKAGAPKN IIGWIENPSL EGTEYVMKNS
DIILATGGPG MVKAAYSSGV PAIGVGAGNA PAIIDDSADL ELATSSIVQS NTFDNGVVCA
TENSVVVLES VYDKVVSLFE KKNTYIVTKE EEKNKFRKAM FKEGKFGLLN SELVGRSALD
VAKLVGIKVP ETTRFILVET ESTEYDEALV HEKLSTYASL YKAKDFDDAI KKSKNILKLG
PGHTASLFIN RKSSIEKVEK FKTLNPGRLL INSPSSLGGV GDMYNFMLEP SLTLGCGTKG
GNSYSQNVTP LNLLNVKSLV ERRENMQWLR LPERIYHKFG SLEVALEDLK DWNIKNVFIV
TDKIINQLYG KRVTSKLDDL NIKYTIFDDV EPNPMLSTTL RGSKMLENIK ADAIIGIGGG
SSMDAAKLMW LYYESEEEVD FKDLAVTFAD IRKRIVRYPN TGRKAKMICI PTTSGTGSEV
TPFSVITDDK DHKKYPLADY SLTPNMAIID PSLTMTVPKG ATNAPALDAL THCLESYVSV
MATEYTDSYA LQGAKNIIEY LPRAYKDGAT DKEAREKVMN GAAFAGLSFA NAFLGIVHSL
SHKIGGYHNV IHGAANAILL PYVIRYNAAC VLEGGKQGYF SQYETQNSME KYASLAKFIG
LKGKSDEELV DALIDKVRAL TKEVELKTNF KDYGVDEKAF LNTLDKMSED AFDDQCTGAN
PRYPLIEDIK QLYMDAYYGK DIKKFSK
//
