ID A0A0K1W247_9MOLU Unreviewed; 480 AA.
AC A0A0K1W247;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=SLITO_v1c06140 {ECO:0000313|EMBL:AKX34248.1};
OS Spiroplasma litorale.
OC Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales; Spiroplasmataceae;
OC Spiroplasma.
OX NCBI_TaxID=216942 {ECO:0000313|EMBL:AKX34248.1, ECO:0000313|Proteomes:UP000067476};
RN [1] {ECO:0000313|EMBL:AKX34248.1, ECO:0000313|Proteomes:UP000067476}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TN-1 {ECO:0000313|EMBL:AKX34248.1,
RC ECO:0000313|Proteomes:UP000067476};
RX PubMed=26430038;
RA Lo W.S., Lai Y.C., Lien Y.W., Wang T.H., Kuo C.H.;
RT "Complete Genome Sequence of Spiroplasma litorale TN-1T (DSM 21781), a
RT Bacterium Isolated from a Green-Eyed Horsefly (Tabanus nigrovittatus).";
RL Genome Announc. 3:e01116-15(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP012357; AKX34248.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0K1W247; -.
DR STRING; 216942.SLITO_v1c06140; -.
DR REBASE; 124702; M.SliTN1ORF6140P.
DR KEGG; sll:SLITO_v1c06140; -.
DR PATRIC; fig|216942.3.peg.622; -.
DR OrthoDB; 32195at2; -.
DR Proteomes; UP000067476; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000067476};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 16..257
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 480 AA; 56576 MW; F9A9B75D529429B9 CRC64;
MKSINSVKIN ERIIKDGVVY TPNYIVINML DEIKYKGKKI LNKHIVDNSC GEGAFLVEIT
KRYLKELLKL KKNRLDVKKH LEKYIHGIEI DPISYKICIS NLNNVLLENG IKVKINWNII
NGDTLECTQF LNKMDYVVGN PPYIRIHDLN IDYKKYNFCT KGMIDLYLIF FEIGLNMLNE
KGKLIYITPN SYFTSNAANV FRKYLIDKSM LETVINLGHF NPFKGITTYP AITVISKIKN
KKTKYKEYDS INNFNFEIDI LEKKEFYIND CFYFSKTKQL LKFSEILNVK KNNDLFVRNG
ISTNLDSFFI NDSYTGSYVV EAMKISKMKL TKMFYPYDED GNTVPLNIIK NENKNMYNLL
LNNKEILSKR SLQSQNWFEF ARTQGIKDVN KNKLVINNII KTVNTIKTKI LKPGIVPYSG
YYVISEKYDL KYIENLIYDQ EFIEYLKILR KDKNGEYYFF SSNDLHQYLS YKIYKINQKN
//
