ID A0A0K1XDF8_9GAMM Unreviewed; 338 AA.
AC A0A0K1XDF8;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Ribosomal RNA small subunit methyltransferase C {ECO:0000256|HAMAP-Rule:MF_01862};
DE EC=2.1.1.172 {ECO:0000256|HAMAP-Rule:MF_01862};
DE AltName: Full=16S rRNA m2G1207 methyltransferase {ECO:0000256|HAMAP-Rule:MF_01862};
DE AltName: Full=rRNA (guanine-N(2)-)-methyltransferase RsmC {ECO:0000256|HAMAP-Rule:MF_01862};
GN Name=rsmC {ECO:0000256|HAMAP-Rule:MF_01862};
GN ORFNames=AKN88_04125 {ECO:0000313|EMBL:AKX59213.1};
OS Thiopseudomonas alkaliphila.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Thiopseudomonas.
OX NCBI_TaxID=1697053 {ECO:0000313|EMBL:AKX59213.1, ECO:0000313|Proteomes:UP000063953};
RN [1] {ECO:0000313|EMBL:AKX59213.1, ECO:0000313|Proteomes:UP000063953}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E5571 {ECO:0000313|EMBL:AKX59213.1,
RC ECO:0000313|Proteomes:UP000063953};
RX PubMed=26679585;
RA Lauer A.C., Nicholson A.C., Humrighouse B.W., Emery B., Drobish A.,
RA Juieng P., Loparev V., McQuiston J.R.;
RT "Genome Sequences of Oblitimonas alkaliphila gen. nov. sp. nov. (Proposed),
RT a Novel Bacterium of the Pseudomonadaceae Family.";
RL Genome Announc. 3:e01474-15(2015).
CC -!- FUNCTION: Specifically methylates the guanine in position 1207 of 16S
CC rRNA in the 30S particle. {ECO:0000256|HAMAP-Rule:MF_01862}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine = H(+) +
CC N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:42736, Rhea:RHEA-COMP:10213, Rhea:RHEA-COMP:10214,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:74269, ChEBI:CHEBI:74481; EC=2.1.1.172;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01862};
CC -!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_01862}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01862}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. RsmC family.
CC {ECO:0000256|HAMAP-Rule:MF_01862}.
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DR EMBL; CP012365; AKX59213.1; -; Genomic_DNA.
DR RefSeq; WP_053100292.1; NZ_CP012365.1.
DR AlphaFoldDB; A0A0K1XDF8; -.
DR STRING; 1697053.AKN87_06120; -.
DR PATRIC; fig|1698449.3.peg.828; -.
DR Proteomes; UP000063953; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0052914; F:16S rRNA (guanine(1207)-N(2))-methyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR HAMAP; MF_01862; 16SrRNA_methyltr_C; 1.
DR InterPro; IPR013675; Mtase_sm_N.
DR InterPro; IPR023543; rRNA_ssu_MeTfrase_C.
DR InterPro; IPR046977; RsmC/RlmG.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR007848; Small_mtfrase_dom.
DR PANTHER; PTHR47816; RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE C; 1.
DR PANTHER; PTHR47816:SF4; RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE C; 1.
DR Pfam; PF05175; MTS; 1.
DR Pfam; PF08468; MTS_N; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01862};
KW Methyltransferase {ECO:0000256|HAMAP-Rule:MF_01862,
KW ECO:0000313|EMBL:AKX59213.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000063953};
KW rRNA processing {ECO:0000256|HAMAP-Rule:MF_01862};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691, ECO:0000256|HAMAP-
KW Rule:MF_01862};
KW Transferase {ECO:0000256|HAMAP-Rule:MF_01862, ECO:0000313|EMBL:AKX59213.1}.
FT DOMAIN 5..141
FT /note="Methyltransferase small N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08468"
FT DOMAIN 162..328
FT /note="Methyltransferase small"
FT /evidence="ECO:0000259|Pfam:PF05175"
SQ SEQUENCE 338 AA; 36900 MW; 7A2C74442C8AC194 CRC64;
MDPRSQVLLR QGHYFSGQLL LAGAPADGLL QQLPSSELWC WNYADYQALA ALQSRAYFSV
TAPDQSYDAV VLYLPKSREL TEYLLQEICA KYPAAEIFLV GEKRAGIERA AKQLAQYGEV
SKLDSARHCQ LWRLTSRKAP VAVPDLAALA NSFAVTVGQQ QLTIKTVPGV FSHGRLDRGT
ELLLAHLEGL PQGHYLDFGC GAGVIGCYLA KQYPNSQVSL LDVDAFALFS TQLTLQANQV
QAEVIAGTGI NEAPQHLAAI ISNPPFHQGV HTDYAASEQM LTQAKGHLRA QGELRIVANS
FLKYPPLINQ HLGPCQVLAE AQGFSVYRAV AGQRSQRQ
//
