ID A0A0K2LUV5_9NOST Unreviewed; 775 AA.
AC A0A0K2LUV5;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU364053};
DE EC=5.6.2.4 {ECO:0000256|RuleBase:RU364053};
GN ORFNames=AA650_02880 {ECO:0000313|EMBL:ALB39547.1};
OS Anabaena sp. WA102.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Anabaena.
OX NCBI_TaxID=1647413 {ECO:0000313|EMBL:ALB39547.1, ECO:0000313|Proteomes:UP000056652};
RN [1] {ECO:0000313|EMBL:ALB39547.1, ECO:0000313|Proteomes:UP000056652}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WA102 {ECO:0000313|EMBL:ALB39547.1,
RC ECO:0000313|Proteomes:UP000056652};
RA Brown N.M.;
RT "The finished genome of an anatoxin-a-producing Anabaena isolate reveals
RT extensive genome rearrangement.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618,
CC ECO:0000256|RuleBase:RU364053};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922, ECO:0000256|RuleBase:RU364053}.
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DR EMBL; CP011456; ALB39547.1; -; Genomic_DNA.
DR RefSeq; WP_053537888.1; NZ_CP011456.1.
DR AlphaFoldDB; A0A0K2LUV5; -.
DR STRING; 1647413.AA650_02880; -.
DR KEGG; awa:AA650_02880; -.
DR PATRIC; fig|1647413.5.peg.679; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000056652; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR005751; ATP-dep_DNA_helicase_PcrA.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR01073; pcrA; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|RuleBase:RU364053};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 9..342
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 343..621
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT COILED 332..399
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 30..37
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 775 AA; 88475 MW; 0CE67A6EBB178FEB CRC64;
MTTNIDFLAH LNPSQRQAVE HYCGPLLVVA GAGSGKTRAL TYRIANLIIK HRVNPENILA
VTFTNKAARE MKERIQRIFT EQLAISQHGK KFDLLTEYEQ SLLKTQVYRT TIKDMWCGTF
HSLFSRILRW DIEKYQDEKG RKWNKNFSIF DESDVQSVIK EIVTKDLNLD SKKFEPKSIR
YAISNAKNQG LSPQQFESEQ PDYRGRVITD VYNRYQDKLA QNNALDFDDL ILIPTRLFQQ
NEQVLAYWHQ KFSHILVDEY QDTNRTQYDL IQLLVTNGET RKSEWKWQNR SVFVVGDADQ
SIYSFRMADF TILLEFQENF GDGLADDDTR SMVKLEENYR SCENILQAAN ELIENNTQRI
DKILKATREP GEGIYCHKAD EEMAEAAFVI NQIRNLEHQH PELNWGNFAI LYRTNAQSRP
FEELLVKYQI PYTVVGGMKF YDRKEIKDAV AYLRAINNPA DTVSLLRVIN TPRRGIGKST
VDALVNASQQ LGTTLWEILS DETSVNTLAG RSAKAVNNFA AMIQNRQEQI KVVPGSEILQ
GVLEDSGYIK ELQDQATDEA DNRISNVNEL YNAMLQFQEE NAGEDISLQA FLQSAALSSD
LDNLKEGQTA VSLMTLHASK GLEFPVVFLV GLEQGLFPGY RSLQDPSLLE EERRLCYVGI
TRAQERLFLS HARERRLYGS REPAMRSQFL DEIPAELLTT QNKVTRSSTK TTSATTSKQT
TPGIWQVGDR VLHKSFGLGE ITHVFGEGNK VSVAIKFLSL GQKIVDPRVA QLQKV
//
