ID A0A0K2YR46_9NOCA Unreviewed; 713 AA.
AC A0A0K2YR46;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:CRK54482.1};
GN ORFNames=RHCRD62_90161 {ECO:0000313|EMBL:CRK54482.1};
OS Rhodococcus sp. RD6.2.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus.
OX NCBI_TaxID=260936 {ECO:0000313|EMBL:CRK54482.1, ECO:0000313|Proteomes:UP000044872};
RN [1] {ECO:0000313|EMBL:CRK54482.1, ECO:0000313|Proteomes:UP000044872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RD6.2 {ECO:0000313|EMBL:CRK54482.1,
RC ECO:0000313|Proteomes:UP000044872};
RA Wang D.B., Wang M.;
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: In the central section; belongs to the 3-hydroxyacyl-CoA
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00007005}.
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DR EMBL; CVQP01000012; CRK54482.1; -; Genomic_DNA.
DR RefSeq; WP_050067378.1; NZ_CVQP01000012.1.
DR AlphaFoldDB; A0A0K2YR46; -.
DR STRING; 260936.RHCRD62_90161; -.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000044872; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43612; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA; 1.
DR PANTHER; PTHR43612:SF3; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000044872}.
FT DOMAIN 323..501
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 504..604
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 713 AA; 75946 MW; EE71871F73D6CDE9 CRC64;
MSDQNIINWE QDADGIVVLT IDDPNQGANT MNDRYISSMK ETVDRLHAEK DSITGVVLTS
GKKTFFAGGD LKNMIKSGPE DAEYIYNHSL ALKADLRRLE TLGKPVVTCI NGAALGGGLE
IALATHHRIA ADVRGVKIGL PEVTLGLLPG GGGVVRTVRM FGLMTALTQM LLQGQQRGPV
EAQKVGLVDE VVSSVEELVP AAKAWIKANP DKNVQPWDVK GYKIPGGTPA TPAFAANLPA
IPANLRKQLK GANMPAPRAI LAAAVEGSQV DVDNALKIES RYFTSLVTGT VAKNMIQAFF
FDLQTINGGG SRPKDVPKRE IKKVGVLGAG MMGAGIAYVS AKAGFEVVLK DVSLEAAERG
KNYSEKIEAK ALSRGKTTEE KSKALLDRIT PSADAADFAG VDFVIEAVFE SVELKQKVFQ
EIEDVVDADA LLGSNTSTLP ITGLATGVNR PEDFIGIHFF SPVDKMPLVE IIRGEKTSDE
ALARVFDYVL AIRKTPIVVN DSRGFFTSRV IGTFVNEAIA MVSEGIEPAT VEQAGMQAGY
PAAPLQLSDE LNLTLMQKIR AETKAAAIAE GKTLPADPAG DVINFLVEGN DRKGRLGGAG
FYNYEEGKRA GLWQGLREQF NSGSATPPIQ DLIDRMLFIE AIETVKCFDE GVLTSTADAN
IGSIMGIGYP AWTGGVSQFV TGYPGGVAGF VARAEELAAK YGERFTPPAS LKG
//
