ID A0A0L0BU80_LUCCU Unreviewed; 3518 AA.
AC A0A0L0BU80;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Unconventional myosin-XV {ECO:0008006|Google:ProtNLM};
GN ORFNames=FF38_14441 {ECO:0000313|EMBL:KNC23543.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC23543.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC23543.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC23543.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC23543.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC23543.1}.
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DR EMBL; JRES01001343; KNC23543.1; -; Genomic_DNA.
DR STRING; 7375.A0A0L0BU80; -.
DR EnsemblMetazoa; KNC23543; KNC23543; FF38_14441.
DR OMA; TFGVHQN; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:UniProt.
DR GO; GO:0030182; P:neuron differentiation; IEA:UniProt.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13201; FERM_C_MyoXV; 1.
DR CDD; cd01387; MYSc_Myo15; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041795; MyoXV_FERM_C.
DR InterPro; IPR036057; MYSc_Myo15.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR PANTHER; PTHR22692:SF26; MYTH4 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 1.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50096; IQ; 3.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000037069};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 64..749
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 921..1070
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 3033..3187
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 3192..3511
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 625..647
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1164..1215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1245..1264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1276..1324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1547..1569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1589..1643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1800..1822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1862..1954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1969..2067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2083..2169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2385..2415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2435..2460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2500..2531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2821..2893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2928..2969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 822..854
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1175..1189
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1250..1264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1309..1324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1589..1603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1620..1636
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1800..1817
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1870..1908
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1927..1954
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1969..2002
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2009..2043
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2083..2114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2385..2410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2510..2531
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2821..2873
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2874..2893
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2931..2969
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 155..162
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 3518 AA; 396368 MW; 75F2133852E072FB CRC64;
MDWSEGDLVW FDPGVGHPIP GEIQEVHRAA QVIVVQAVIK GKPQTFALQP GEGNLRPRQD
LGSSGVDDMT MLDDLHEASL LWNLRLRYDK GLIYTFAGSI LIAVNPYKMF PDSYGLEVAK
QYAGKPLGTM PPHLFAIGAA AHAALPSPQV VVISGESGSG KTESTKLVMQ YLAAVVPGGG
SASAVITEQI LEAAPLLEAF GNARTARNDN SSRFGKYLEV YFKNGAIVGA KITQYLLEKS
RIVTQAPGER NYHVFYEMLG GLSEAERTKY GLLEADKYFY LNQGATDCAP GRVDWDSLQS
AMQVLGVSEG EREGIIRVLA SVLHLGNVYF HRRQLRHGQE GVEVGSDAEI KWAAHLLHIS
AEGLHRALTS RITEARSERL HTPLSIDQAL DSRDAFAKAL YSGLFNWLVS RINSIVQKGG
THDAHRISIL DIFGFEDLAE NSFEQLCINY ANENLQLYFN KHVFKLEQAE YSRERLEWTP
LTWDDNLPVI HLLAKKPVGI FHLLDDESNF PRASDMSFLE KCHYNHALNE LYSRPRIGAQ
EFGITHYAGQ VWYCVDGFLD KNRDALRSDV LELLGSSKLQ LVSDLTKQLR AQRDSGKTLP
KGNNGRFVTM KPRTPTVAAR FSDSLQQLLQ SMGRCNPWFV RCIKPNNEKQ SLKMDMPCVL
QQLRYLGMLD TIQIRQKGYP VRLRFQHFVE RYRHLMRSPL PRGTPYRELC RILLESMPNT
GIEGPDYQLG ATRVFLREAL HRMLESGRSD RLKTSAVVIQ KHVRGMLVRR QLARKKKAAT
RIQTKWRGYR EQKKFRDLRR GAIKAQALWR GKMGRKRVVK LRADYQRRLE AQRAQKEREA
KKQAKENLER SQISYLDIPA ELAFIFSKSE GWTPIHGDRH LVKVVGTVPG PPVAADLPKD
LDQFSFGKFS SVYCNGLRLS SRREPITTPF LTRAASRDQD FQDSLAVFKL ILRWTNDKTM
DGNKEKVLSD YIVHKGLSSR GLRDEILVQL CNQVYNADDL QAQRIWQLMA QCLSCFQPGP
AFSKYLMKFI VDNAPDSMRD MLLKKILRNA NSANNCRNFT PSWVEWRAIS RMSDIAVALT
LPDDANQTVA IDSWTTCEEA ASLAVSTLGI SNRGWTVVLD DGKLVTDSCG LDYVLDLISE
KELCPAFPAL RSDLMTTGAK FNRTILSDHD GNTPRRPQVP PPEPPKIKVN PTSESPISDS
NDEKPIRKNS RNLLSRSSAL NERYFEQEKS RSKSLDDLLA GDITDLDPAT ETEPLTNLGL
SESRLNERYH SAERLTPMGK ETGPRYQKSQ YAGRRSHAGS HSSKYMDKSE YATRSSAMSD
TSEAPSLASH VRRVRVPSQA SDVDQFLDDL FSPVLDGSLD ELSDARSLAA SIRGGKAMPD
LSFELDDTEF LEAPDSEMND LIWDSHTLAC KIKGGGENSA NSEEAPSANL DEYITGLFKP
IFVNDAVKVL TEQAELIETI KGGGTAQAQT SGNSTFVTSP IVGPISPILA SNSENLLQIV
NLPPDADPAV YQHQVQRAFL QSAMAQNLQI QQQLLAQNQA LQTLLSQQDT APTGTTSPPP
LMPVLASVQQ SSASSNSITS KITIASSEHT NVRKQSVKNR ISQFSENDRN RKVSSDSGGS
LIPPPPPPPM PPPIEVKDPS ETRHFLDPYG RAKTVRIGKW RWPPPQDGPQ FETEEDFFAF
KMRQNQRKTT PQSQFHSSNG SLTGSAMEWE EFEVNDSSKS PSPAVVMPVH TTQMVRTQIK
IETGPKNTNK QPTMEQLQPQ QTVITTKVAK KSFEIGADRP PPGSVGKLKL SSEMRQRLEQ
VTAGHSVRST VSTKSEQRAP AKLEDTRKLM LQQQLSGHFA QIESNNNAVA DLHSVRSQVE
RMEEKLSPPP IWPSHVPPAP NIPAPPPPIR PPNVAPPAPP PVPKSPPVRP DQEEIEYRSQ
SKDVPAFIQR QERDTFGARH NWNGSDDSKD AYDSWGRTEA AKLDMVYEKS FKKESKNNHE
RDRSRSRSRS RDRDDFSESV WDRSEVEGPA SSGSDREREK EREKRDRIYE MRQVEREKES
NKVYQPAPPK VVTATIERQD RTDSFGPMVS TERKYSYQAM ASNNNNNINN KRPITSAPSP
TTSMTSNTPA TFRTHMAQKY EKERKRKSSA TSTTVSQSTR RDEETDGGDE WPLPAIPAPV
PAPPSLKSPA NACLTYNRVP WKLRVRKEVF HPNEPIGPPI ALDLLFAQVS SDIFGLTPSL
RISPQEKAAA INMLNGHGVT VETVRSQNVR ALVKRHLIDM AREWPLYFAR LFPVQGAPQY
PDVSIMGISH NGLYLARRDA DYLIVVQSVP FNEIQNAITL PRPASLQLNL RNGKNVQLHA
ARAAAIQAMI TSFVQEFRKI YKTTPSFFVS RYYLLLVFGS KMSESLRGSK SSNSRHNSSS
SGSGNGSHGR NLDSIPHKFS SIVNKVESLI NKMNYDKHNH NNRHDGEKCS SSHKENKRKT
KIKQEYKQNN RYDHSIALNC NNRTTSMDSL NNLTDIEIDS FDDRDTNDTR TTNTNTTNTT
TTSNNTNDIY SDSDDAEIAH ITGTTSVQVH RRIELDQLTD ETIREFNEQC SSLSHDMEFY
NSWQNEEELE HSSTHTSKHS NEDDIYDDSI QHQFNSCQQN TEIDQHTTTT TTTKDANNNE
CSASEIDTQD WLDKLEMNEE EEPVEKHQEY KTETNKPLTH IQQIVNNITQ QSSNLKEQHS
KQNYNEIEID STINEDGSSN SFTNQTSTAI NGNMAKTRRS SVASSGSVGR METILEEPTE
CKISVKEILQ RFETMNKNET QSKASTLSSG VRAAAQTLNV PIERLESRQS NHREQINSNQ
HSVITQQHNM RNTSSPLMSG SYEEQHLHHQ QQQQQLQQQQ THHNLQQQQQ QSHHHQREQL
REPHSRNMHH GISDSIDHHT QITQASHHYN GHGDEDERLD DREHFNEHHQ YAKQQSFLHS
SRKNSNQHHS STNPHTREHH SAVQQTQQSQ NLDANYMAEE HNGGTTSPSV TRYSLLQFAM
QHFRNDQIVD SRSHGRDASE RSSNRSYAEL VKWQGTPMRI PLLRLPNDLA PLALECFDCI
LRYCGDIPME PDLTEVKCVY TVLMHCHKYL ALRDEVYCQL MKQTTANRSP CPDSTQRGWR
LLSILAAYFG CSDALRPYLI EHLTSAASDR RRSCHGTAAV CLTNLRKTAR CGGRKNVPSV
EEVTAVSAGR SARRQIYRLP GGAERVVNTR CSTVVADVIS ELCALLGIES ETEQQEFSLY
CIVQGDAFTM PLAADEYILD VTTELLKSGQ PFYLIFCRSV WHFALKRDPA PTPLYVEVLF
NQVAPDYLEG LLLELPSTGV PPPEVVRDMA RIAALLHRAA DLSHVPAMKE IKFLLPKPAL
GIREIRPAQW VGLVQSAWPQ VANLSPGQVK AQFLNVLSAW PLFGSSFFAV KRIWADEGPH
VDDSPMWRDL ILALNRRGVL FLDPNTHETM QHWPFMEVIS TRKVRSEDGA LFLDMKVGNL
MQQRVIRVQT EQAHEISRLV RQYITMAQIS QRDKRDVN
//
