ID A0A0L0BXA5_LUCCU Unreviewed; 919 AA.
AC A0A0L0BXA5;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Ras GTPase-activating protein 1 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=FF38_01516 {ECO:0000313|EMBL:KNC24677.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC24677.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC24677.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC24677.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC24677.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC24677.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JRES01001194; KNC24677.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0BXA5; -.
DR STRING; 7375.A0A0L0BXA5; -.
DR EnsemblMetazoa; KNC24677; KNC24677; FF38_01516.
DR OMA; ICGCLQR; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:UniProt.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0060429; P:epithelium development; IEA:UniProt.
DR CDD; cd08400; C2_Ras_p21A1; 1.
DR CDD; cd13260; PH_RASA1; 1.
DR CDD; cd10354; SH2_Cterm_RasGAP; 1.
DR CDD; cd10353; SH2_Nterm_RasGAP; 1.
DR CDD; cd11788; SH3_RasGAP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR035842; RasGAP_C_SH2.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR035841; RasGAP_N_SH2.
DR InterPro; IPR035652; RasGAP_SH3.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10194:SF146; RAS GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 2.
DR Pfam; PF00017; SH2; 2.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00252; SH2; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 148..238
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 245..307
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 317..405
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 444..549
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 548..662
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 718..912
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 60..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 919
FT /evidence="ECO:0000313|EMBL:KNC24677.1"
SQ SEQUENCE 919 AA; 104100 MW; FF7475630C2101BF CRC64;
MSLHSFKSLS NTSECSNKSS TTTLSSSSST TTSSSILSTS SRSYLMDSIV KPATCRRSSL
NPQQHLNNYN KNNNNNNNNN NVINEHNNNI NNNDGGNCNH RRSISISDDI GGMIVDFDNV
DAIINYVIKM QYICSERPAI IAPPESEWYH GRLDRYSAES RLRGSSKLGS YLVRESDRKP
GSYVLSYLGR TGINHFRITA VCGDFYIGGR QFISLSDLVG YYTSCSDLLK RERLVFPVPP
PEPVNDKKRV VAILPYTKMP DTDELSFQKG DIFFVHNDMG DGWLWVTAHR TGEQGMIFRE
LVDDLDPAID PNTVFPWFHP NCTKNEAVDM LVKAGPGSFL VRPSDNSPGD YSLFFHINNQ
IQRFRIEKKG VRYLMGGRTF ECLDAVINRY RKEQIVEGHC LSHPVVNGSQ PEFNQQYVVE
KAAEKIYATL RECRDQIGLK KIKGIKHHGQ LNKKSDKTAK WKQLYFALIS EGSETHLCFY
DNPKKTKPKG LIDLSCAYLY QCHDSLWERP YCFQIVERAL PCLATVTYLC APSQESYVEW
INALKAQCVS QLSKAQKKVP RLRELRCLNL HILEAHRLPF KLVPHPYCSI SLNQVKVGKT
KVKIAPDPVW EEEFVLDDVP PDVVSLTITL ISRGKRGKDS EVAELTIELA SLKNGQETEE
WYQLTGMTPM GEWGSLRLRM RYLDDLIMPC EEYSPLQQLL LEPELYAVKA LAELCHNDRV
PLATALLRVF RHEKRETELI RVLCQAEIAR ENETTTLFRG ASLATTLMDL YMRTECTGFL
QAAVSETIQR IMDSKQSAEL NPTKMDVNDD ACSNAEFLLQ ILDLVTHSIF TSPEACPRSV
RFICNCLQKA VVAKWPTERL VRTRVVSGFI FLRLLCPSLL NPRQFGLVSE TPPTAATRSL
IMVAKCLQNL ANLIEFGGK
//
