ID A0A0L0C6C3_LUCCU Unreviewed; 1145 AA.
AC A0A0L0C6C3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
GN ORFNames=FF38_06141 {ECO:0000313|EMBL:KNC27938.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC27938.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC27938.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC27938.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC27938.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361199};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC27938.1}.
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DR EMBL; JRES01000835; KNC27938.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0C6C3; -.
DR STRING; 7375.A0A0L0C6C3; -.
DR EnsemblMetazoa; KNC27938; KNC27938; FF38_06141.
DR OMA; GHQWLKY; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10809; GH38N_AMII_GMII_SfManIII_like; 1.
DR Gene3D; 2.60.40.1360; -; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR041566; AManII_C.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR048534; Man2a1-like_dom.
DR PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR PANTHER; PTHR11607:SF3; LYSOSOMAL ALPHA-MANNOSIDASE; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF18230; Glyc_hyd_38C_2; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR Pfam; PF21260; Laman-like_dom; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW Hydrolase {ECO:0000256|RuleBase:RU361199};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361199};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT DOMAIN 495..572
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
FT REGION 65..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1145 AA; 132646 MW; 134530D99E4E1928 CRC64;
MLRIRRRFAL VLCAVFVAIF LAVYFLINYA APAEDNKKPN FMNLDNIEAL KQKMDLPKVL
ETNNLENNNV GEKPQRQTEH FKKSGQGVKR KEGDGDELKI EQNMISENKD DTCDFDPQQV
PQPNIQMLDL YGKMKFDNPD GGVWKQGWNI KYDPLQYNDH HKLKVFVVPH SHNDPGWIKT
FDDYYDHETK HILSNALRHL RENPEMKFIW AEISYFAKFY QDLGESNKQE IKKLVANGQL
EFVTGGWVMP DEANSHWHNI LLQLTEGQHW LKKYLNVTPT SSWAIDPFGH SASMPYILKK
SGFTNSLIQR THYSVKKELA LKRNLEFYWR QLWDDTGSTD LFTHMMPFYS YDIPHSCGPD
PKICCQFDFK RVPNFGLMCP WKVPPQTIDD HNVAQRAELI IDQWKKKAEL YRTNVVLFPL
GDDFRYSQST EWEVQRVNYE NLFNHINSER KYFVEAKFGT LQEYFDAVHQ EQKEKQRDFP
TLSGDFFTYA DRNDNYWSGY YTSRPYHKRM DRVLMHYIRS AEILSSWDKW DESSKFDEML
QDARRQLSLF QHHDGITGTA KTHVVEDYNR RMMDAIKSCR FVMQQAIYRL LTKPSIYNAD
NNFNYFFMDD SRWPGPDDSR TTIILGEELP QKHLVFHNSL PQWREDIVDF YIASPYVSVV
DFNNNPVDIQ ISPVWTWHKH TLTNTITPQA STTKYRLIFK AKVPPLGLST YIVKVETPET
IKPNYITFAS NLILTKNPIT TQLGDYPKEV KFGKHREISL KVGSGPTVAF SAEGMMKSIQ
IKESEAHTPV RVQFFKYGVR QKGEYSGAYL FLPNGFASQI TNAQQPVVLV TKGPLESSIS
VGLSFGVHHT ILRDGEAPEI RNNIDINDMD DTEIVMRFQT RIHNDETFYT DLNSLQLIKR
QRFTKIPLQG NYYPIPSAIY IEDDTLRLTV VSAQPLGGSS LADGEVEIMQ DRRLTHDDER
GLGQGVLDNQ PVLHIFRVLL ERIDNCEKLA DNHPSGILTL PAYRNLKSIL DPIDKFIFTE
NDWLGVMPEF GSSHTALGED MEIVVMRNLP ASSAIPAIAR DRKPHMQQNT GLIIHRTNLM
QCSGLQAQNT GELNLHHLLQ WGSQNVSAVY KTNLTFLKRL SSQKIDEDIT LCPMDSLAFI
LQRHS
//
