ID A0A0L0C8H5_LUCCU Unreviewed; 1329 AA.
AC A0A0L0C8H5;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Ionotropic glutamate receptor C-terminal domain-containing protein {ECO:0000259|Pfam:PF00060};
GN ORFNames=FF38_05741 {ECO:0000313|EMBL:KNC28545.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC28545.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC28545.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC28545.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC28545.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC28545.1}.
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DR EMBL; JRES01000760; KNC28545.1; -; Genomic_DNA.
DR STRING; 7375.A0A0L0C8H5; -.
DR EnsemblMetazoa; KNC28545; KNC28545; FF38_05741.
DR OMA; FTNYEIC; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0050907; P:detection of chemical stimulus involved in sensory perception; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR PANTHER; PTHR42643; IONOTROPIC RECEPTOR 20A-RELATED; 1.
DR PANTHER; PTHR42643:SF37; IONOTROPIC RECEPTOR 84A; 1.
DR Pfam; PF00060; Lig_chan; 2.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1329
FT /note="Ionotropic glutamate receptor C-terminal domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005536080"
FT TRANSMEM 398..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 453..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 645..667
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1049..1070
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1106..1130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1295..1317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 398..626
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00060"
FT DOMAIN 1047..1303
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00060"
SQ SEQUENCE 1329 AA; 152687 MW; 6F6E6B3CD712720A CRC64;
MQLLIIAITL LFYVNKSVEG NCNNNKSNDK WLTSAKGSKK DSVKSITLAY FQYHAVRSLN
LIVCPANSTG IKGSKLHFPI VNKVIKISAL EISSMVLFYM EHNLPVRVWS GEDYLPEMPK
REVFGPPITF REVKNDSYRR PLKLKLEPLA HKTGVMIIDF NTPCALNVLR WSAASENNYF
KTNSFWLLIT KDIEDLKALE DEDIFLPPDS EVKVLVEGIN KTFSLLDIYK VAAFKPLKQN
MVAENFSKVE VMCKALSSYG SVISLRENLE GIVFNTGLVI NFPDMFTDIE DLSLRHIDTM
AKVTNRLVVD MARKLNLRFN TYQTDNYGWH KPNGSFSGLM GRFQRYELDF GQMAFFMRLD
RTKVCNFLVE TFRIRAGIMF RQPPLSSVAN IFTMPFDIKV WICLIILIVL TICVFALELA
LSPYTHDMHY WDCIIFVWGA MCQQGFYGSI SNLSARIIIF TTFVATLFLF ISFSANIVAL
LQSPSEAIRT LNDLSHSSLE LGVMDTVYNR VFLNESTDPV TRYLYRKKIL PKGESIYMSP
AVGINKMRYE TFAFQVELQT GYQIISDTFS EPEKCGLKEM EPYKLPMIAV PTRKNFPYKE
LFRRQLRWQR EVGLMNREEM KWFTQRPKCE GLGRFVSIGL KECRYAWAVL GWGCLFALIA
LGCELLMKKA ALLLYVFNKV KQCDQVVAVK SSLNDASNYE LQGEGKNVLM PNIILAYFRY
HGVRSLNIIR CPSNETTAIK LSSLAWFFLK HNMLLHVWSG KDYLKELPEP PLYGPANTFK
VFSNDTYRRP LKFKLEPLAH KTGVLLMDFN TPCGLNVLRW SAASENNYFT TNKFWLFTTK
DFSDLSSLND EDIFLPPDGE VKVLVQDQSK RFSLLDIYKV AAFKPLKLNF VLQNFTEVKH
MLRALRSYGS VISLRENLEN ITFNTGIVIA FPDMFTNIED LNMRHIDTIS KVNNRLTIEL
ANKLNMHFNT HQTDNYGWHQ PNGSFDGLMG QFQRYEMDFG QLAIFMRLDR MALCDFVAET
FRVRAGIMFR QPPLSAVANI FAMPFENDVW ISLVVLVIVT ICLFALELLF SPHNHQMDYL
DCAVFVWGAM CQQGFYVAVG NRSARIIIFT TFVATLFLFT SFSANIVALL QSPSEAIHTL
KDLSQSPLEI GVQDTVYNKI YFNESTDPVT NLLYHKKIAP KGDSIYMRPT IGIQKMRSGM
FAYQVELHTG YQIISNTFSE PEKCGLKSLE PFQLPMIAIP TRKNFPYKEL FRRQLRWQRE
VGLMNREDRK WFPQKPKCES GMGGFVSIGI TECRYALAIF GFGSLFAGAV FCVELLLKHS
FKLWKFVKK
//
