ID A0A0L0C8R5_LUCCU Unreviewed; 599 AA.
AC A0A0L0C8R5;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Pleckstrin homology domain-containing family F member 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=FF38_04888 {ECO:0000313|EMBL:KNC28666.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC28666.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC28666.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC28666.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC28666.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC28666.1}.
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DR EMBL; JRES01000755; KNC28666.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0C8R5; -.
DR STRING; 7375.A0A0L0C8R5; -.
DR EnsemblMetazoa; KNC28666; KNC28666; FF38_04888.
DR EnsemblMetazoa; XM_023440368.2; XP_023296136.1; LOC111678915.
DR OMA; HNDSHAN; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15717; FYVE_PKHF; 1.
DR CDD; cd01218; PH_Phafin2-like; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037871; PH_Phafin.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46280:SF3; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 1 HOMOLOG; 1.
DR PANTHER; PTHR46280; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 2-RELATED; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 338..434
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 455..515
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 171..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 599 AA; 68601 MW; BCB104762F273633 CRC64;
MAFLNCKMQQ EQHKFDWDDI NVGNSQLDDS QNFFSKKHYE HERVDEMEFL QQKMIKTELN
ESIENKENIK ANFTSPVQKS ENKLLNEHLS PSIVKVEDEE CAASPVDVNK EPQDGRELCL
KVAPNLACEW STKKTICSQA VGLHKGAISK NVPPPPQAYL VKDIYQRNRE EAERRRAEEE
RKMREFHSRP APNFNHHHEL LQKRKPAHAV TVAVTPQVLK KSREAEEKRR KRLEEWKQKN
QVPKFEPRPP TVLKEKPFVP EKKPMVVQMC PFKLHTEKRL QERKHYDEIK QKALEEKQKQ
VEIMVDRLVN SEANSRRIAM VENCFGSSGV PLAIPGRVLV GEGVLTKMCR KRPKSRQFFL
FNDILVYGNI VIGKKKYNKQ HIMPLEEVSL ENIDDCVQYR NGWLIRTTTK SFVVCAATAT
EKQEWMAHIN KCVEDLLRKS GKKPVENHAA VWVPDAEATV CMHCKKTQFT MIVRRHHCRN
CGAVVCGPCS SKKFLLPQQS TKPQRVCTSC YERLSKAVKQ ESSKIHSAVN NQSHNDSHAN
TAESSGDDDS DEETNGAGTE QHDQPKFYGD TSILSVNDAT KNETSSSATQ LNSSHSPSN
//
