ID A0A0L0CJD5_LUCCU Unreviewed; 534 AA.
AC A0A0L0CJD5;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Regulatory protein zeste {ECO:0000256|ARBA:ARBA00016807};
GN ORFNames=FF38_12469 {ECO:0000313|EMBL:KNC32327.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC32327.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC32327.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC32327.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC32327.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- FUNCTION: Involved in transvection phenomena (= synapsis-dependent gene
CC expression), where the synaptic pairing of chromosomes carrying genes
CC with which zeste interacts influences the expression of these genes.
CC Zeste binds to DNA and stimulates transcription from a nearby promoter.
CC {ECO:0000256|ARBA:ARBA00025466}.
CC -!- SUBUNIT: Self-associates forming complexes of several hundred monomers.
CC {ECO:0000256|ARBA:ARBA00011764}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00371}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC32327.1}.
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DR EMBL; JRES01000319; KNC32327.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0CJD5; -.
DR STRING; 7375.A0A0L0CJD5; -.
DR EnsemblMetazoa; KNC32327; KNC32327; FF38_12469.
DR OMA; AQHHAHN; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR InterPro; IPR004210; BESS_motif.
DR InterPro; IPR028002; Myb_DNA-bind_5.
DR PANTHER; PTHR23098; AGAP001331-PA-RELATED; 1.
DR PANTHER; PTHR23098:SF17; NUCLEAR APOPTOSIS-INDUCING FACTOR 1; 1.
DR Pfam; PF13873; Myb_DNA-bind_5; 1.
DR PROSITE; PS51031; BESS; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00371};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069}.
FT DOMAIN 270..309
FT /note="BESS"
FT /evidence="ECO:0000259|PROSITE:PS51031"
FT REGION 144..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..430
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 534 AA; 61126 MW; C4CCBD7D8565B33A CRC64;
MVFNILFKDR VTKPQKKMLI TLLRETKYME GKKEKEWYWE KIQEALNKIG PKKTIIQWKK
CWRDMRLTTR KKLAELKRCQ MAGGSPPPGI ELSQEDNDII DIVGTEYFYE EMNGELKPEN
FMSGFDYVPE HFCDAILTAA AVSSGQQQHM QHQKEQHAAQ QQQDHHTNDG ETNDAPGSSN
HTDTQAGGFG QAGVSQMTGH NGDHSNSTGT LQQHNIMPPH PAFSGGLHPH LMRRQQHATA
AFHREAAFEE KLLQFMQDAF PKKSKKRKSR DPDKLFLLSL YEEIKRVPED IRIDVKGELI
QVLKKYQKKA PVKQEKTHHN HTQSSSSSGK SSGNTTPNDK IQLPQHTQLS HSMYQLQKKY
DKSEKEPSPQ SQADRVQQHA REQTSTTTVA LHAPQQIHTL FQLQKKYEET TAEKVHQQNE
QRKHVDAAHQ QHQAAHQQPP PPPPSNEQHL HHPQMPHGIM FPLPQIRNEQ PGAQQQQHHT
HNPHQQPQQA QHPHQQTQQQ QQQQHHPPSI FGNSTASAPG MSTDRPAMPY ENVG
//
