ID A0A0L0CK18_LUCCU Unreviewed; 843 AA.
AC A0A0L0CK18;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Rho GTPase-activating protein 92B {ECO:0000313|EMBL:KNC32562.1};
GN ORFNames=FF38_13089 {ECO:0000313|EMBL:KNC32562.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC32562.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC32562.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC32562.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC32562.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC32562.1}.
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DR EMBL; JRES01000301; KNC32562.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0CK18; -.
DR STRING; 7375.A0A0L0CK18; -.
DR EnsemblMetazoa; KNC32562; KNC32562; FF38_13089.
DR OMA; WDYFFEG; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07595; BAR_RhoGAP_Rich-like; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047165; RHG17/44/SH3BP1-like.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14130; 3BP-1 RELATED RHOGAP; 1.
DR PANTHER; PTHR14130:SF14; RHO GTPASE-ACTIVATING PROTEIN 92B; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069}.
FT DOMAIN 252..447
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 49..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 126..160
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 466..490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..531
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..605
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..690
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 843 AA; 94436 MW; E7439292DA47DFEC CRC64;
MKKQFTKIKI AAENLSRSNK PDRKDFELET IEKQVEKYRD VLDKMVRKLP TVPNSSSSGG
SADLQERDKR IKKQTHYKIG QALEESSKEL SKDMPLHHVL VNCGELEKSI AECIVDSELE
TECEVVRRLK LILDNEIQEI STLKRNVSRT LQEYASLKRN YEAAIRLDEP QAKINHIKDQ
QEQCEIKLEK ERDSWAAQMF ELIAKEDVIV QCIRDYVLNQ RNYHERALQK VNTSLANIQD
IIQSTVKSRF GTSLTDHLDS TNREISYIIE LCVCCLVENG LSEEGLLRVG CASTKLRRMK
HALEAQYVKT PLPLDYQDPH VIGSILKLYL RELPEPLLTF KCYKDFLKAV EKHSEEERKI
EIKNTLAKLP TSNYLNLRYL TKFLWLVTQN VDCNKMSSHN LAIVMSPNML WPRVDKNNPA
DYMGQVNSSS AVNIIVELLI SQWDYFFEGE VDFFVTLQRG KLFVEDKSKS NSSNENLDRH
DIDLSDSPRY GTIRRQKPCA PSPPAKPQNI VVSSDPNGST ANETTKNNGE LQHNNHQRAK
ELFPSNNINT TQAVTNNNNN SSSAEKPEIP PLPKQLLLQQ QQQQQTNQNE TNTTITTNTT
HPPISAKPVP MTRTQFFGLD NLPSPTADRK SNDSVSSLNF KPDLPQKPKI PKRPMVLGLS
TTTTAGGNGS GINNKSDEES TPTNNSQNTS DCCTATNGSL RGHKTAEQLV QEHCDNVTAL
QANIGSSNTS IPSAILKETN HNNHLNLQTT TATTTTTANH NTNNQGNLEV NANAMTAPSP
LIPPPPAVTV AKVMTTNTNT TDKPLEIRLT TPTTPVSPNM IMTPKRPTVP APPPPTSAKK
LSE
//
