ID A0A0L0CUG1_PLAFA Unreviewed; 518 AA.
AC A0A0L0CUG1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=PFLG_00680 {ECO:0000313|EMBL:KNC35887.1};
OS Plasmodium falciparum RAJ116.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=580058 {ECO:0000313|EMBL:KNC35887.1, ECO:0000313|Proteomes:UP000054566};
RN [1] {ECO:0000313|Proteomes:UP000054566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RAJ116 {ECO:0000313|Proteomes:UP000054566};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum RAJ116.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RAJ116 {ECO:0000313|Proteomes:UP000054566};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Godfrey P., Alvarado L.,
RA Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA White J., Yandava C., Wirth D.F., Nusbaum C., Birren B.;
RT "The genome sequence of Plasmodium falciparum RAJ116.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00104}.
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DR EMBL; GG663946; KNC35887.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0CUG1; -.
DR EnsemblProtists; KNC35887; KNC35887; PFLG_00680.
DR OrthoDB; 1386at2759; -.
DR Proteomes; UP000054566; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:KNC35887.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054566};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 282..420
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
SQ SEQUENCE 518 AA; 62301 MW; 54B4A687DECE447C CRC64;
MYDQNSYVVN KGHVYLNVQE DNICLIKRNI ENEDKEQSVK CYNSMDEIKN IFDELDKINM
YNYDNYVDRH MFFYNKNNTN MEHLKFAHNV KSFSNDESFQ YSTPFESSSF VNNNNNNNNN
NNYSHTHINH SYNERIMTSN HNNMSSHNRG EFFFDNLKNK NTNTKKKIND DSCYSNVINY
YLYKNDNKGL SYILPILLKK LYKLNSYIHI FDDEFFVIKE TFNLLKNRFH IIGESNNINY
NNNNNNNNNN NNNNSNDEET TLYLEKNDIY LNNNIKFVNV LANYLLRYVP FTLPFDDHKN
GNEETGIDGG GLFKEFIILL CREIFHENFI LFQNVENHTL FPKYYNENDN LILYEFSGKI
IGKAIYERIL IESVFNKVFL NNLIFDNMDI NDLYFIDQNV FNSLLYVQND ENVEKLCLTF
CIYEKKYPDG EKFTKEQYDK ITNYFYELSK RNHNNMYSLH THHNNIINNN NNNNNNNLFF
FNQMDNLENL FFSSDDNTYN FTNMNNFFHM INNFRFYD
//
